Background: Though local anesthetic agents are widely used to provide postoperative analgesia in intra-articular route, their efficacy is not accepted universally. Objective: The present study has been conducted to compare the analgesic effects of intra-articular ropivacaine between two different doses following arthroscopic knee surgery. Study design: Double-blinded randomized controlled trial. Total 60 patients of ASA (American Society of Anesthesiologists) physical status I and II, 34 male and 26 female, aged between 18 to 60 years, were randomized into 3 groups receiving 10 ml normal saline, 10 ml 0.5% ropivacaine and 10 ml 0.75% ropivacaine respectively, administered in intra-articular space at the end of operation. Results: Ropivacaine groups had significantly delayed first post-operative rescue analgesic request with significantly lesser requirement of rescue analgesia in first 24 hours (p<0.001 in both cases). Except 6th post-operative hours, ropivacaine groups also showed significantly less VAS scores (Visual Analogue Scale) up to 12 hours post-operatively (p<0.05). Conclusion: In our double-blinded randomized controlled trial, administration of intra-articular 0.75% ropivacaine showed superior analgesic efficacy following arthroscopic knee surgery. Further, larger trials are needed to confirm our findings. DOI: http://dx.doi.org/10.3126/ajms.v6i1.9703 Asian Journal of Medical Sciences Vol.6(1) 2015 81-86
Background: Though anxiety is associated with increase in heart rate and cardiac output, there is conflicting reports regarding its effect on propofol induction dose. Aims and Objectives: The aim of the study was to delineate the correlation between pre-anesthetic anxiety and heart rate on propofol requirement for induction. Materials and Methods: Total 42 patients of ASA (American Society of Anesthesiologists) physical status I and II, 13 male and 29 female, aged between 18 to 50 years and scheduled for elective surgery under general anesthesia, were enrolled in this study. Trait anxiety in the waiting room and state anxiety both in the waiting room and operating room were assessed using Spielberger's revised State-Trait Anxiety Inventory (STAI) scale. After heart rate (HR) recording, anesthesia was induced with 200 ml/hr 1% propofol infusion till loss of verbal contact. Results: Pre-anesthetic trait anxiety and HR had strong positive correlation with propofol requirement (ρ>0.6, P<0.05) while state anxiety had not. But pre-anesthetic state anxiety measured just before induction is strongly associated with increase in HR (ρ>0.6, P<0.05).Conclusion: Pre-operative anxiety should be considered and the dose of propofol should be titrated for induction accordingly. Further, larger trials with more sophisticated monitoring are needed to confirm our findings.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.