Prevalence of Neutralizing Antibodies against Different Rotavirus Serotypes in Children with Severe Rotavirus-Induced Diarrhea and Their Mothers

Ray, Pratibha G.; Kelkar, Shobhana D.

doi:10.1128/cdli.11.1.186-194.2004

Cited by 22 publications

(35 citation statements)

References 54 publications

(34 reference statements)

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“…This finding reinforces the hypothesis that some novel strains of RV may emerge in newborns whose high titers of maternal antibody to common strains select for strains that contain novel serotype antigens. In a recent study, Ray and Kelkar observed that low titers of neutralizing antibodies to common strains (e.g., G1, G2, G4, and G9) among the mothers predisposed the children to infection with those serotypes (17). In another study, Ramachandran et al noted that low titers of neutralizing antibodies to strain 116E in cord blood predisposed newborns to infection with 116E-like strains (15).…”

mentioning

confidence: 99%

First Detection of G12 Rotaviruses in Newborns with Neonatal Rotavirus Infection at All India Institute of Medical Sciences, New Delhi, India

Ray¹,

Sharma²,

Agarwal

et al. 2007

J Clin Microbiol

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mentioning

confidence: 99%

First Detection of G12 Rotaviruses in Newborns with Neonatal Rotavirus Infection at All India Institute of Medical Sciences, New Delhi, India

Ray¹,

Sharma²,

Agarwal

et al. 2007

J Clin Microbiol

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“…We previously reported G9 RVs to be prevalent in the Indian nurseries and were a source of asymptomatic infection in newborns (Das et al, 1994;Ray et al, 2007). In addition, another study from Western India observed relatively high percentages of NtAb against G9 RVs (Ray & Kelkar, 2004). Similarly, Brüssow et al (1991) also observed high prevalence of G9 antibodies in European and Central American children (Brüssow et al, 1991).…”

mentioning

confidence: 90%

Convalescent phase sera from children infected with G12 rotavirus cross-neutralize rotavirus strains belonging to the Wa genogroup

Sharma

Nakagomi

et al. 2010

Journal of General Virology

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“…The mother of the child had low NAb titer against G3, and no NAbs against G9, and hence could not confer protection to the child. On the contrary, high percentage of NAb to simian G3, SA11 was reported among young Indian mothers [Ray and Kelkar, 2004a].…”

mentioning

confidence: 92%

Dual infection due to simian G3—human reassortant and human G9 strains of rotavirus in a child and subsequent spread of serotype G9, leading to diarrhea among grandparents

Awachat

Kelkar

2005

Journal of Medical Virology

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Cultivation of rotavirus from day 1 and 3 fecal specimens of a child yielded simian SA11-human reassortant, G3P [8] and AU32 like G9P [8] rotavirus strains, respectively. Diarrhea developed in the grandfather by sheer hospital visits, and in the grandmother, after wiping the vomit of the grandfather. AU32 like G9 strains were isolated from the grandparents also. Rotavirus specific IgM developed in all the three patients. A fourfold rise in G9 neutralizing antibodies was observed in the child and grandmother. The child's mother had asymptomatic rotavirus infection. The study highlights the potential of G9 serotype to spread from children to adults. J. Med. Virol. 78:134-138, 2006. ß 2005 KEY WORDS: rotavirus; adult diarrhea; simian G3 SA11-human reassortant; G9 serotype; dual infection Group A rotavirus is known as the major cause of severe dehydrating diarrhea in infants. More than 90% of children get rotavirus infection by 3 years of age. Generally, group A rotavirus is a common cause of pediatric diarrhea but less common among adults, who appear to undergo rotavirus infections mostly with minimal or no clinical manifestations [Kapikian et al., 2001]. On the contrary, group B rotavirus was involved in epidemics of severe gastroenteritis in China, which led to large outbreaks mainly among adults although children were also affected.Studies in the late 1970s and 1980s showed the presence of symptomatic rotavirus infections in adults, particularly in the elderly [Wenman et al., 1979;Cubitt and Holzel, 1980;Marrie et al., 1982;Hrdy, 1987]. Group A rotavirus has also been documented as the cause of adult diarrhea outbreaks in hospitals, nursing homes, travelers, geriatric wards, isolated communities, and families including children and adults participating in playgroup [Bishop, 1994;Kapikian et al., 2001]. In a 4 year study between 1996 and 1999 carried out both on hospitalized and out patients in Japan, group A rotavirus was detected in 97(14%) of 683 adult patients with diarrhea suggesting the importance of this disease in adults may be highly underestimated [Nakajima et al., 2001]. It has been reported that, as children can be infected by rotavirus through older siblings or adults in contact, at times parents may also be infected from children undergoing rotavirus diarrhea due to group A rotavirus [Kapikian et al., 2001].Rotavirus serotypes involved in few outbreaks have been identified in the recent studies. G1 serotype was the etiological agent in an outbreak which lasted for 3 weeks that occurred in a psychiatric nursing home for adults in Hungary [Banyai et al., 2002]. Between November 1998 and December 2000, three/263 gastroenteritis outbreaks among adults in United States were associated with rotavirus serotype G2 [Griffin et al., 2002]. Similarly, the etiological agent responsible for two gastroenteritis outbreaks among children and adults in Japan was serotype G2 [National Institute of Infectious Diseases, 2000a,b]. Rotaviruses were detected in seven gastroenteritis outbreaks, in aged care facilities i...

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Prevalence of Neutralizing Antibodies against Different Rotavirus Serotypes in Children with Severe Rotavirus-Induced Diarrhea and Their Mothers

Cited by 22 publications

References 54 publications

First Detection of G12 Rotaviruses in Newborns with Neonatal Rotavirus Infection at All India Institute of Medical Sciences, New Delhi, India

First Detection of G12 Rotaviruses in Newborns with Neonatal Rotavirus Infection at All India Institute of Medical Sciences, New Delhi, India

Convalescent phase sera from children infected with G12 rotavirus cross-neutralize rotavirus strains belonging to the Wa genogroup

Dual infection due to simian G3—human reassortant and human G9 strains of rotavirus in a child and subsequent spread of serotype G9, leading to diarrhea among grandparents

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