Prevalence of Mycoplasma Conserved DNA in Malignant Ovarian Cancer Detected Using Sensitive PCR–ELISA

Role of Bacteria in Oncogenesis

“…In tissue specimens from actual patients, mycoplasmas are found in precancerous lesions as well as in malignant tissues, such as those from stomach, colon, ovarian, and lung cancers (43,112,129,142,191). The prevalence of mycoplasma infection is significantly higher in stomach and colon cancer tissues than in their respective precancerous lesions (112).…”

Detection of <i>Mycoplasma </i>species in cell culture by PCR and RFLP based method: Effect of BM-cyclin to cure infections

“…Similar sensitive methods have also been used to know the possible aetiology of Mycoplasma infections in certain chronic diseases. 11,12 However, drawback of the studies conducted is that none of the primers used is speciÞ c for the identiÞ cation of species-speciÞ c Mycoplasma (Mollicutes) present in cell culture, virus stocks or any other chronic disease. 3,12 Hence, detection and identiÞ cation of species-speciÞ c Mycoplasma associated in cell cultures or virus stocks by using highly sensitive molecular methods such as PCR and restriction fragment length polymorphism (RFLP) based assays is of great importance in cell culture and virology laboratories.…”

p37 induces tumor invasiveness

“…One report indicated that 48% of tumors from patients with gastric cancer were positive for mycoplasma (11). Another study involving patients with ovarian cancer revealed a mycoplasma infection rate of 59.3% (12), and the same authors detected a relationship between cervical cancer and mycoplasma infection with 72 archived paraffin-embedded sections (13). In contrast, another group found only a 13% infection rate in ovarian cancer in 46 frozen tumor samples and concluded that there was no significant relationship between mycoplasma infection and ovarian cancer (14).…”