Prevalence of mupirocin resistant Staphylococcus aureus isolates among patients admitted to a tertiary care hospital

Abstract

Background:For the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections and decolonization of MRSA carriers, the use of mupirocin a topical antibiotic is increasing day by day.Aim:The present study was carried out to determine the prevalence rate of high-level and low-level mupirocin resistant MRSA isolates among patients admitted to a tertiary care hospital.Materials and Methods:This is a prospective study carried out on MRSA isolated from the various clinical specimens from outpatient and inpatient departments during period of one year. A total of 82 MRSA isolates were recovered from 6468 different clinical specimens. Mupirocin resistant MRSA was detected by two different methods: Epsilometer test (E-test) and agar dilution method. D-shaped zone test (D-zone test) was also performed for determination of inducible clindamycin resistance in MRSA isolates.Results:Out of 82 non-duplicate MRSA isolates mupirocin resistance were found in 15 (18.3%) isolates by both E-test and agar dilution method. Of these 15 mupirocin resistant, 8 (53.3%) isolates were high-level resistant (MuH) and 7 (46.7%) isolates were low-level resistant (MuL). Four isolates were D-zone test positive showing simultaneous inducible clindamycin resistance among mupirocin resistant MRSA isolates.Conclusion:Higher prevalence of both high-level and low-level of mupirocin resistant MRSA was observed in patient from the population. It is advisable to perform routine test to detect MRSA colonization among health care workers and nasal decolonization to prevent spread of MRSA infections among hospitalized patients.

Antibiotic Susceptibility Pattern of Methicillin Sensitive and Resistant Staphylococcus aureus from Clinical Isolates in a Tertiary Care Hospital at Mathura, Western Uttar Pradesh

“…Data on the prevalence of MRSA is not uniform. Literature has documented a significant variation in the prevalence rate from different parts of India and between countries [1][2][3][4][5][6][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] . Studies from India report MRSA prevalence ranging from 6.9% to 87% 9 .…”

“…Distribution of MRSA in different clinical samplesSome authors18,[20][21][22] have predominantly isolated MRSA from skin and soft tissue infections.…”

Nasal carriage of Methicillin- and Mupirocin-resistant S. aureusamong health care workers in a tertiary care hospital

“…[ 7 ] The increased pressure of antibiotic use has led to the emergence of mupirocin resistant S. aureus (MupRSA), and the clinicians are left with few alternatives to prevent the spread of MRSA. [ 8 ]…”

Antibacterial Effect of Zinc Oxide Nanoparticles on Mupirocin-Resistant Staphylococcus aureus Isolated From Nasal Carriers

“…19 However, according to the study carried out by Joshi et al and the one by Chaturvedi et al in India and that of Babu et al during 2007Babu et al during -2008 in the United States, the strains with higher resistance were more frequent. [20][21][22] The reason for such high resistance to mupirocin in these studies might be the indiscriminate consumption of the antibiotic or non-selection of proper anibiotic for treatment in those hospitals. In the study carried out by Saderi on 94 S. aureus isolates from 4 hospitals affiliated to the University of Tehran using PCR, 6 isolates were found to be resistant to mupirocin.…”