Antibacterial Effect of Zinc Oxide Nanoparticles on Mupirocin-Resistant Staphylococcus aureus Isolated From Nasal Carriers

Hajimohammad, Afsaneh; Fozouni, Leila

doi:10.15171/ijbsm.2018.14

Cited by 6 publications

(3 citation statements)

References 22 publications

(23 reference statements)

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“…However, the authors in [67] reported that TiOPs had no antibacterial effect. Many authors have reported antibacterial effects of ZnONPs against several isolates, such as Staphylococcus sp., [68] methicillin-resistant Staphylococcus aureus, [69], Pseudomonas sp. [70] and Escherichia coli [71].…”

Section: Discussionmentioning

confidence: 99%

Interactive Effects of Biosynthesized Nanocomposites and Their Antimicrobial and Cytotoxic Potentials

et al. 2021

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The present study investigated the biosynthesis of silver (AgNPs), zinc oxide (ZnONPs) and titanium dioxide (TiO2NPs) nanoparticles using Aspergillusoryzae, Aspergillusterreus and Fusariumoxysporum. Nanocomposites (NCs) were successfully synthesized by mixing nanoparticles using a Sonic Vibra-Cell VC/VCX processor. A number of analytical techniques were used to characterize the synthesized biological metal nanoparticles. Several experiments tested biologically synthesized metal nanoparticles and nanocomposites against two types of human pathogenic bacteria, including Gram-positive Staphylococcus aureusand methicillin-resistant Staphylococcus aureus (MRSA), and Gram-negative Escherichia coli and Pseudomonasaeruginosa. Additionally, the antitumor activity in HCT-116 cells (colonic carcinoma) was also evaluated. Significant antimicrobial effects of various synthesized forms of nanoparticles and nanocomposites against E. coli and P. aeruginosa bacteria were detected. Various synthesized biogenic forms of nanoparticles and nanocomposite (9.0 to 29 mm in diameter) had high antibacterial activity and high antitumor activity against HCT-116 cells (colonic carcinoma) with IC50 values of 0.7–100 µg/mL. Biosynthesized NPs are considered an alternative to large-scale biosynthesized metallic nanoparticles and nanocomposites, are simple and cost effective, and provide stable nanomaterials.

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Section: Discussionmentioning

confidence: 99%

Interactive Effects of Biosynthesized Nanocomposites and Their Antimicrobial and Cytotoxic Potentials

et al. 2021

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“…In the present study, 31 (18.9%) of the hospital staff were nasal carriers of S. aureus. As reported by researchers in Iran in 2010 (18) and 2018 (19), 32% and 26.8% of the hospital staff were carriers of S. aureus. It was higher than the amount found in the present study.…”

Section: Discussionmentioning

confidence: 78%

The Potency of Tedizolid, Linezolid, and Vancomycin Against Extensively Drug-Resistant Staphylococcus aureus Clinical Isolates

Fozouni

Pishdad

Kolbadinezhad

2022

Zahedan J Res Med Sci

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Background: Staphylococcus aureus is considered a normal flora by colonization in the nose and skin of humans, yet it is a major cause of nosocomial infections and a life-threatening pathogen. Among antibiotics, oxazolidinones and glycopeptides have activity against gram-positive pathogens. Objectives: The present study aimed to determine the frequency and comparison of the minimum inhibitory concentration of tedizolid, linezolid, and vancomycin against extensively drug-resistant (XDR) S. aureus strains isolated from hospitalized patients. Methods: This descriptive-analytical study was performed on 58 S. aureus isolates collected from 164 hospitalized patients over the course of one year. The Kerby-Bauer test was used to identify XDR isolates. Broth microdilution test was used according to CLSI M100-S25 (2015) criteria to determine the minimum inhibitory concentration (MIC) of vancomycin, linezolid, and tedizolid. Results: The frequency of XDR S. aureus clinical isolates was 28 (48.3%). Determining MIC showed that all XDR S. aureus isolates tested were susceptible to tedizolid (MIC, ≤ 2 μg/mL), while 92/8% (MIC, ≤ 4 μg/mL) and 60.70% (MIC, ≤ 2 μg/mL) of XDR isolates were categorized as susceptible to linezolid and vancomycin, respectively. The concentration of tedizolid that inhibited 90% of isolates (MIC90) was 2 μg/mL, 2-fold lower than linezolid (MIC90 = 4 μg/mL) and 64-fold lower than vancomycin (MIC90 = 128 μg/mL). There was a significant difference between the frequency of XDR isolates from the aspirate, trachea, and wound infections, so 22% of vancomycin-resistant isolates and all strains resistant to linezolid were isolated from hospitalized patients in the infectious ward (P = 0.04). Conclusions: We conclude that tedizolid has a beneficial effect on XDR isolates of S. aureus and possesses more potent in vitro activity than the rest agents.

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“…In the present study, out of 91 samples taken from restaurant staff, S. aureus was isolated from 29 samples (32%), while 55% of the subjects were nasal carriers of S. aureus. Previous studies in Iran in 2011 (14) and 2018 (15) reported that the frequency of S. aureus carriers was 32% and 26.8% among the hospital staff, respectively. In line with our findings, studies in the Netherlands (16) and Brazil (17) reported that 20-50% and 22.1% of adults were nasal carriers of S. aureus, respectively.…”

Section: Discussionmentioning

confidence: 93%

Molecular Investigation of Enterotoxigenic Staphylococcus aureus Isolates from Restaurant Staff

Tahaei

Fozouni

Khademi

2022

Middle East J Rehabil Health Stud

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Background: Intoxication by heat-resistant Staphylococcus aureus enterotoxins (SEs), particularly SEA and SEE, is one of the most common causes of food poisoning in the world. Objectives: This study aimed to identify enterotoxin-encoding genes (see, sed, sec, seb, sea) in S. aureus isolates from different restaurant employees. Methods: Ninety-one samples from the hands and noses of employees of several restaurants in the Golestan Province (North of Iran) were examined for detection of S. aureus strains by the phenotypic and microbiological genotyping methods. After determining the susceptibility of the isolates to ten antibiotics by the Kirby-Bauer method, the enterotoxin-producing genes were detected using the polymerase chain reaction method. Results: S. aureus was detected in 29 (31.9%) samples. The frequency of S. aureus isolates was highest in waiters (65.5%) with the age range of 34 - 49 years (41.4%) and nasal samples (55.1%). The highest and lowest susceptibility rates were observed against linezolid (100%) and cefoxitin (17.24%). Of 19 methicillin-resistant S. aureus strains, 89.47% were identified as multi-drug resistant and 10.52% as extensively-drug resistant. Of 29 S. aureus isolates, 24.13% were enterotoxigenic, with the highest frequency belonging to SEA (57.1%). Conclusions: In this study, we isolated multi-drug resistant, enterotoxigenic S. aureus from different restaurant employees, which can have important public health implications. Therefore, it is recommended to closely monitor the health, sanitation, and hygiene of people involved in food preparation to reduce the spread of bacteria in the food chain.

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Antibacterial Effect of Zinc Oxide Nanoparticles on Mupirocin-Resistant Staphylococcus aureus Isolated From Nasal Carriers

Cited by 6 publications

References 22 publications

Interactive Effects of Biosynthesized Nanocomposites and Their Antimicrobial and Cytotoxic Potentials

Interactive Effects of Biosynthesized Nanocomposites and Their Antimicrobial and Cytotoxic Potentials

The Potency of Tedizolid, Linezolid, and Vancomycin Against Extensively Drug-Resistant Staphylococcus aureus Clinical Isolates

Molecular Investigation of Enterotoxigenic Staphylococcus aureus Isolates from Restaurant Staff

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