Prevalence of Multiple Sclerosis in Bulgaria

Milanov, Ivan; Georgiev, Dejan; Kmetska, K.; Jordanova, Ludmilla; Topalov, N.

doi:10.1159/000109701

Cited by 18 publications

(19 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, when the two studies are compared after age and gender adjustment, these differences (MS rates and demographic characteristics, such as age, of both groups) become insignifi cant. The prevalence rate and average age of patients in this study was much higher than in our study, and was also higher than epidemiological studies carried out in neighboring countries (11)(12)(13)(14)(15)20).…”

Section: Discussioncontrasting

confidence: 81%

“…We therefore believe that the prevalence rate detected in our study is broadly consistent with the actual prevalence rate in the study region. Similar prevalence rates were reported for neighboring countries (10,11,13). Yet, it is still possible that different prevalence rates may be found in different regions in Turkey, as ethnic backgrounds are heterogeneous throughout the country.…”

Section: Discussionsupporting

confidence: 71%

“…The methodological design used in the Turk-Boru et al study has been used in various studies (16). The rate of prevalence they observed was much higher than those of both neighboring countries and ours (11)(12)(13)(14)(15). We had previously reported the preliminary part of our study as a poster (15).…”

Section: Introductioncontrasting

confidence: 48%

“…On the other hand, MS prevalence rates in countries neighboring Turkey were lower; 38.9/100 000 in Greece (10), 39.3/100 000 in Bulgaria (11)(12)(13), and 35.5/100 000 in Iran (14).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Prevalence Of Multiple Sclerosis In The Metropolitan Area Of Edirne City, Turkey

Çelik¹,

Birgili²,

Kiyat³

et al. 2010

TUTFD

View full text Add to dashboard Cite

Objective: The prevalence and incidence of multiple sclerosis may vary according to the infl uence of the altitude of a geographical area as well as the genetic and environmental factors. This study ained to determine the incidence and prevalence of multiple sclerosis in Edirne population. Material and Methods:Patients with a defi nite diagnosis of MS according to McDonald's criteria, admitted to one of the three MS clinics in Edirne, were included in this two-stage study. Also the records of hospitals in İstanbul serving patients from Edirne, have been evaluated. Results:The prevalence rate of confi rmed MS patients was 33.9/100000 (95% CI: 32-36) in 2003. The mean annual incidence was 3.48/100000 (95% CI: 2.90-4.00). Mean age of the patients was 36.5±9.6 years. Mean age at onset was 29.2±8.5 years. Mean duration of disease was 6.9±5.2 years. Overall, 69.2% had a relapsing-remitting course, 20.5% had a primary progressive course and 10.3% had a secondary progressive course. Mean Expanded Disability Status Scale score was 3.04±2.18. The prevalence and annual incidence after one year was 36.5 per 100000 (95% CI: 33.2-38.6) and 2.60 per 100000 (95% CI: 2.1-3.8), respectively. Conclusion:This is the fi rst city-based MS prevalence study performed in Turkey. The MS prevalence in Edirne is similar to that of Greece and Bulgaria but lower than that of European countries.

show abstract

Section: Discussioncontrasting

confidence: 81%

Section: Discussionsupporting

confidence: 71%

Section: Introductioncontrasting

confidence: 48%

“…On the other hand, MS prevalence rates in countries neighboring Turkey were lower; 38.9/100 000 in Greece (10), 39.3/100 000 in Bulgaria (11)(12)(13), and 35.5/100 000 in Iran (14).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prevalence Of Multiple Sclerosis In The Metropolitan Area Of Edirne City, Turkey

Çelik¹,

Birgili²,

Kiyat³

et al. 2010

TUTFD

View full text Add to dashboard Cite

show abstract

“…org/news-messages/ms-registry-and-national-representation/). The literature search found only 16 studies, of which the last epidemiology study was in 1997 (33), and reported a considerably lower prevalence of MS in Bulgaria comparing with the neighboring countries.…”

Section: % Of Patientsmentioning

confidence: 99%

Living with Multiple Sclerosis in Europe: Pharmacological Treatments, Cost of Illness, and Health-Related Quality of Life Across Countries

Gitto

2017

Multiple Sclerosis: Perspectives in Treatment and Pathogenesis

View full text Add to dashboard Cite

More than 700,000 people suffer from multiple sclerosis (MS) in Europe. This implies that more than 1 million people are affected by this disease through their role as caregivers and family members. Given its relevant impact, MS deserves consideration by epidemiologists, clinicians, psychologists, social scientists and other scholars. Such interdisciplinarity is stressed in the present contribution, which focuses on various aspects of socioeconomic burden. Starting from considerations about the epidemiology of the disease in Europe, as outlined by the MS Barometer, a comparative survey based on data collected by the national MS societies and launched in 2008, a brief literature review for each European country mentioned in the report was carried out with the following key terms: "multiple sclerosis," "cost of illness," and "health-related quality of life (HRQoL)." The consideration of the level of assistance provided, the access to rehabilitation centers, and the availability of pharmacological treatments, Drugs, Costs and Quality of Life for MS Patients in Europe 18especially innovative therapies, reveal how there are still huge differences across Europe. Literature contributions are mostly oriented toward HRQoL studies and the impact of new pharmacological treatments. There are less studies focusing on compliance: this may be the consequence of a higher awareness of the disease among the patients and a strengthened cooperation with the physicians. Some suggestions about foreseeable and desirable lines of research conclude the contribution.

show abstract

The prevalence of multiple sclerosis in the world: an update

Rosati

2001

Neurological Sciences

560

405

View full text Add to dashboard Cite

The systematic study of multiple sclerosis (MS) in populations, started in 1929 by Sydney Allison, now consists of over 400 publications dealing with the prevalence of MS throughout the world. However, any attempt to redefine the pattern of geographical differences in MS frequency remains as difficult as ever. The comparison of prevalence studies carried out in different areas and times is made difficult by the variability in surveyed population sizes, age structures, ethnic origins and composition, and the difficult quantification of numerators, especially regarding the recognition of benign and very early cases. Additionally, complete case ascertainment depends on access to medical care, local medical expertise, number of neurologists, accessibility and availability of new diagnostic procedures, the degree of public awareness about MS, and the investigators' zeal and resources. Critical examination of the more recent data on MS prevalence leads to some revisions of previously held concepts, the most interesting of which is the appreciation of the greater influence of genetic factors on disease acquisition. The rarity of MS among Samis, Turkmen, Uzbeks, Kazakhs, Kyrgyzis, native Siberians, North and South Amerindians, Chinese, Japanese, African blacks and New Zealand Maoris, as well as the high risk among Sardinians, Parsis and Palestinians, clearly indicate that the different susceptibilities of distinct racial and ethnic groups are an important determinant of the uneven geographic distribution of the disease. The updated distribution of MS in Europe, showing many exceptions to the previously described north-south gradient, requires more explanation than simply a prevalence-latitude relationship. Prevalence data imply that racial and ethnic differences are important in influencing the worldwide distribution of MS and that its geography must be interpreted in terms of the probable discontinuous distribution of genetic susceptibility alleles, which can however be modified by environment. Because the environmental and genetic determinants of geographic gradients are by no means mutually exclusive, the race versus place controversy is, to some extent, a useless and sterile debate.

show abstract

Prevalence of Multiple Sclerosis in Bulgaria

Cited by 18 publications

References 1 publication

Prevalence Of Multiple Sclerosis In The Metropolitan Area Of Edirne City, Turkey

Prevalence Of Multiple Sclerosis In The Metropolitan Area Of Edirne City, Turkey

Living with Multiple Sclerosis in Europe: Pharmacological Treatments, Cost of Illness, and Health-Related Quality of Life Across Countries

The prevalence of multiple sclerosis in the world: an update

Contact Info

Product

Resources

About