Prevalence of Molecular Subtypes of Breast Cancer: A Single Institutional Experience of 2062 Patients

Pandit, Prakash; Palwe, Vijay; Gandhe, Sucheta; Patil, Rahul

doi:10.5152/ejbh.2019.4997

Cited by 42 publications

(39 citation statements)

References 27 publications

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“…This age at presentation in our current study is in agreement with a previous Togolese study were the mean age at diagnosis of cancer was 50 years [10]. This is also similar to the mean age reported in Ghanaian patients at Korle bu Hospital [16] and in Indian women [17], but different from the relatively younger age of women with breast cancer reported in several studies in others countries in Africa [12,[18][19][20][21][22].…”

Section: Discussionsupporting

confidence: 92%

“…had positive lymph nodes and the majority had T3 or T4 tumors stage. These unfavorable clinicopathological characteristics such as high grade, large tumors size, axillary lymph node involvement and advanced stage are the same as those reported in several studies [14,15,17,21,26,27]. The advanced stage of diagnosis in our patients could be explained by the delay of consultation, the absence of national breast cancer screening program in the population, the poor health care facilities and the use of traditional medicine.…”

Section: Discussionsupporting

confidence: 85%

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Breast Cancer in Togolese Women: Immunohistochemistry Subtypes

ADANI-IFE¹,

AMEGBOR²,

DOH³

et al. 2020

Preprint

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Background Molecular classification of breast cancer is an important factor for prognostic and clinical outcome. There are no data regarding molecular breast cancer subtypes among Togolese women. The objective of this study was to evaluate the expression of ER, PR, HER2 and molecular subtypes of breast cancer receptor in Togolese patients and to establish the correlation between clinical and histological data and molecular types. Methods Clinicopathologic data of patients were collected from clinical records. Immunohistochemistry biomarkers (ER, PR and HER2) were assessed in patients who have been diagnosed with invasive breast cancer from March 2016 to March 2020 in the department of oncology. The analysis of variance and the Chi-square Test were used to analyze the data. Results A total of 117 cases were collected. Mean age of patients was 52.05 ± 12.38 with an age range of 30 to 85 years. Half of patients were over 50 years old and majority (70.9%) was postmenopausal. More than half of patients (52.1%) presented with T3-T4tumors.The most common histologic subtype of breast cancer was invasive ductal carcinoma of no special type (95.7%). Tumors grade 2 were predominant (51.3%) followed by grade 3 (42.7%). Advanced carcinomas were found in 69 patients (59%). The percentage of ER+, PR + and HER2 positive tumors was 50.4%, 37.6% and 15.4% respectively. The predominant molecular subtype was Luminal A (42.7%) followed by Triple negative (41.9%), Luminal B subtype (9.4%) and HER2 enriched (6%). There was significant association between tumor size and breast cancer subtypes (p = 0.026) but no correlation was found with age, stage, menopausal status and histologic grade. Conclusion Breast carcinoma in our patients are high grade tumors and are diagnosed at advanced stage. Luminal A and triple negative are the two predominant breast cancer subtypes in Togolese women. Consequently, Receptor testing availability should be a priority in order to offer the best breast cancer treatment.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 85%

Breast Cancer in Togolese Women: Immunohistochemistry Subtypes

ADANI-IFE¹,

AMEGBOR²,

DOH³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…This age at presentation in our current study is in agreement with a previous Togolese study where the mean age at diagnosis of cancer was 50 years [ 10 ]. This is also similar to the mean age reported in Ghanaian patients at Korle bu Hospital [ 16 ] and in Indian women [ 17 ] but different from the relatively younger age of women with breast cancer reported in several studies in others countries in Africa [ 12 , 18 – 22 ].…”

Section: Discussionsupporting

confidence: 85%

“…Our study revealed that less than 10% of women with breast cancer have well-differentiated tumors, 42% had positive lymph nodes and the majority had T3 or T4 tumors stage. These unfavorable clinicopathological characteristics such as high grade, large tumors size, axillary lymph node involvement, and advanced stage are the same as those reported in several studies [ 14 , 15 , 17 , 21 , 26 , 27 ]. The advanced stage of diagnosis in our patients could be explained by the delay of consultation, the absence of a national breast cancer screening program in the population, the poor health care facilities, and the use of traditional medicine.…”

Section: Discussionsupporting

confidence: 85%

Breast cancer in togolese women: immunohistochemistry subtypes

et al. 2020

View full text Add to dashboard Cite

Background Molecular classification of breast cancer is an important factor for prognostic and clinical outcomes. There are no data regarding molecular breast cancer subtypes among Togolese women. The objective of this study was to evaluate the expression of ER, PR, HER2, and molecular subtypes of breast cancer receptors in Togolese patients and to establish the correlation between clinical and histological data and molecular types. Methods Clinicopathologic data of patients were collected from clinical records. Immunohistochemistry biomarkers (ER, PR, and HER2) were assessed in patients who have been diagnosed with invasive breast cancer from March 2016 to March 2020 in the department of oncology. The analysis of variance and the Chi-square Test was used to analyze the data. Results A total of 117 cases were collected. The mean age of patients was 52.05 ± 12.38 with an age range of 30 to 85 years. Half of the patients were over 50 years old and the majority (70.9%) was postmenopausal. More than half of patients (52.1%) presented with T3-T4tumors.The most common histologic subtype of breast cancer was invasive ductal carcinoma of no special type (95.7%). Tumors grade 2 were predominant (51.3%) followed by grade 3 (42.7%). Advanced carcinomas were found in 69 patients (59%). The percentage of ER+, PR+, and HER2 positive tumors was 54.7%, 41%, and 15.4% respectively. The predominant molecular subtype was Triple negative (37.6%), followed by Luminal A (30.8.7%), Luminal B subtype (23.9%), and HER2 enriched (7.7%). There was a significant association between stage and breast cancer subtypes (p 0.025), histologic grade, and subtype (p < 0.0001) but no correlation was found with age, menopausal status, and tumor size. Conclusion Breast carcinoma in our patients are high grade tumors and are diagnosed at an advanced stage. Triple negative and Luminal A are the two predominant breast cancer subtypes in Togolese women. Consequently, Receptor testing availability should be a priority to offer the best breast cancer treatment.

show abstract

“…Our study revealed that less than 10% of women with breast cancer have well-differentiated tumors, 42% had positive lymph nodes and the majority had T3 or T4 tumors stage. These unfavorable clinicopathological characteristics such as high grade, large tumors size, axillary lymph node involvement, and advanced stage are the same as those reported in several studies [14,15,17,21,26,27]. The advanced stage of diagnosis in our patients could be explained by the delay of consultation, the absence of a national breast cancer screening program in the population, the poor health care facilities, and the use of traditional medicine.…”

Section: Discussionsupporting

confidence: 85%

Breast Cancer in Togolese Women: Immunohistochemistry Subtypes

ADANI-IFE¹,

AMEGBOR²,

DOH³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Molecular classification of breast cancer is an important factor for prognostic and clinical outcomes. There are no data regarding molecular breast cancer subtypes among Togolese women. The objective of this study was to evaluate the expression of ER, PR, HER2, and molecular subtypes of breast cancer receptors in Togolese patients and to establish the correlation between clinical and histological data and molecular types. Methods: Clinicopathologic data of patients were collected from clinical records. Immunohistochemistry biomarkers (ER, PR, and HER2) were assessed in patients who have been diagnosed with invasive breast cancer from March 2016 to March 2020 in the department of oncology. The analysis of variance and the Chi-square Test was used to analyze the data. Results: A total of 117 cases were collected. The mean age of patients was 52.05±12.38 with an age range of 30 to 85 years. Half of the patients were over 50 years old and the majority (70.9%) was postmenopausal. More than half of patients (52.1%) presented with T3-T4tumors.The most common histologic subtype of breast cancer was invasive ductal carcinoma of no special type (95.7%). Tumors grade 2 were predominant (51.3%) followed by grade 3 (42.7%). Advanced carcinomas were found in 69 patients (59%). The percentage of ER+, PR+, and HER2 positive tumors was 54.7%, 41%, and 15.4% respectively. The predominant molecular subtype was Triple negative (37.6%), followed by Luminal A (30.8.7%), Luminal B subtype (23.9%), and HER2 enriched (7.7%). There was a significant association between stage and breast cancer subtypes (p 0.025), histologic grade, and subtype (p<0.0001) but no correlation was found with age, menopausal status, and tumor size. Conclusion: Breast carcinoma in our patients are high grade tumors and are diagnosed at an advanced stage. Triple negative and Luminal A are the two predominant breast cancer subtypes in Togolese women. Consequently, Receptor testing availability should be a priority to offer the best breast cancer treatment.

show abstract

Prevalence of Molecular Subtypes of Breast Cancer: A Single Institutional Experience of 2062 Patients

Cited by 42 publications

References 27 publications

Breast Cancer in Togolese Women: Immunohistochemistry Subtypes

Breast Cancer in Togolese Women: Immunohistochemistry Subtypes

Breast cancer in togolese women: immunohistochemistry subtypes

Breast Cancer in Togolese Women: Immunohistochemistry Subtypes

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