Prevalence of migraine headaches in patients with allergic rhinitis

Ku, Min Jung; Silverman, Bernard A.; Prifti, Nausika; Wang, Ying; Persaud, Yudy K.; Schneider, Arlene T.

doi:10.1016/s1081-1206(10)60018-x

Cited by 82 publications

(46 citation statements)

References 31 publications

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“…Even though headache was considered as a TEAE in this study, a strong connection between AR and the occurrence of migraine appears to exist. According to Ku et al [39], more than 34% of patients with AR experience migraine headaches, compared with only 4% of people without AR. Among mechanisms involved in the development of headaches in patients with AR is implication of the immune system with histamine release [40].…”

Section: Discussionmentioning

confidence: 99%

Triamcinolone Acetonide versus Fluticasone Propionate in the Treatment of Perennial Allergic Rhinitis: A Randomized, Parallel-Group Trial

Karaulov

Vylegzhanina

Овчинников

et al. 2019

Int Arch Allergy Immunol

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Background: Intranasal sprays are recommended as targeted therapy for allergic rhinitis (AR). Triamcinolone acetonide is a nasal corticosteroid preparation indicated for the treatment of seasonal and perennial AR (PAR) in different countries worldwide. Objectives: In order to determine the efficacy of triamcinolone acetonide in the treatment of PAR, the non-inferiority of triamcinolone acetonide to fluticasone propionate was assessed in Russian adults. Methods: In this randomized, double-blind, parallel-group, multicenter, prospective, non-inferiority, phase III clinical trial, a total of 260 patients with persistent PAR were randomized to receive either triamcinolone acetonide or fluticasone propionate nasal sprays for 4 weeks. The efficacy in symptom control was evaluated using the reflective total nasal symptom score (rTNSS) from baseline (day 0) to day 28. Safety was assessed through the reporting of adverse events. Results: The rTNSS mean values decreased from baseline to the end of study treatment (day 28) in both groups: –8.2 ± 3.0 in the triamcinolone acetonide arm versus –8.0 ± 2.8 in the fluticasone propionate arm. The mean difference between the groups (triamcinolone acetonide – fluticasone propionate) for rTNSS change from baseline was –0.2 (95% confidence interval –0.89 to 0.54), with an upper confidence limit of 0.54, which is lower than the non-inferiority margin of 0.8. Triamcinolone acetonide was well tolerated, with no difference in adverse event occurrence compared with fluticasone propionate. Conclusions: Triamcinolone acetonide proved to be non-inferior to fluticasone propionate in adult patients with PAR; both treatments decreased rTNSS values and showed a good safety profile.

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Section: Discussionmentioning

confidence: 99%

Triamcinolone Acetonide versus Fluticasone Propionate in the Treatment of Perennial Allergic Rhinitis: A Randomized, Parallel-Group Trial

Karaulov

Vylegzhanina

Овчинников

et al. 2019

Int Arch Allergy Immunol

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“…In studies from referral clinics, a variety of atopic disorders including rhinitis, conjunctivitis, food and drug allergy, as well as a family history of atopic disorders, has been noted in more patients with than without migraine (8). Likewise, patients in treatment for allergic rhinitis were significantly more likely to suffer from migraine headaches than those without allergic rhinitis (10). Support for these associations in population surveys of adults in Norway (11), England and Wales (12), and the United States (30) confirm that the association of asthma, hay fever and chronic bronchitis with headache is not an artifact of treatment seeking bias, and that the potential mechanisms for these non-random associations requires further investigation.…”

Section: Discussionmentioning

confidence: 99%

Physical Comorbidity of Migraine and Other Headaches in US Adolescents

Lateef

Cui

Nelson

et al. 2012

The Journal of Pediatrics

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Background Evidence regarding associations of headache with other somatic conditions in children has been largely based on clinical samples. The objective of this study was to examine the pattern and extent to which other physical conditions are comorbid with migraine and other headaches among youth in a representative sample of the US population. Methods The National Comorbidity Survey-Adolescent Supplement (NCS-A) is a face-to-face survey of adolescents aged 13–18 years in the continental United States. Sufficient information to assess the International Headache Society criteria for Migraine with and without Aura over past 12 months was available in the diagnostic module. A caretaker/parental self-administered report (PSAQ) was used to assess a broad range of other physical conditions. The sample for these analyses included 6843 adolescents with systematic caretaker/parent reports. Results Individuals with any headaches reported higher rates of other neurologic conditions such as epilepsy (OR 2.02 [95% CI: 1.04–3.94]), persistent nightmares (OR 2.28 [95% CI: 1.34–3.87]), and motion sickness (OR 1.6 [95% CI: 1.07–2.4]), as well as abdominal complaints (OR 2.36[95%CI: 1.59–3.51]). Adolescents with migraine more often reported asthma (OR 2.22 [95% CI: 1.26–3.92]) or seasonal allergies (OR 1.66 [95%CI: 1.12–2.48]) compared to those with non-specific headache. Conclusions Adolescent migraine is associated with inflammatory conditions such as asthma and seasonal allergies, and with epilepsy, persistent nightmares and motion sickness. Findings suggest that comorbid medical conditions should be evaluated comprehensively in determining treatment options in youth with headache. Such comorbidity could also be an important source of clinical and etiologic heterogeneity in migraine.

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“…In a questionnaire study among 30,000 Norwegians aged 30 to 44 years, with a 71 % response rate, Aaseth et al [ 56 ] found that those with chronic rhinosinusitis had a ninefold increased risk of chronic headaches compared with the general population. Similarly, Ku et al [ 57 ] reported that migraine was diagnosed much more often in allergic rhinitis patients (occurring in 34 %) than in the control group without allergic rhinitis (occurring in 2 %). In patients with allergic rhinitis, the development and course of migraine may have a significant allergic component [ 58 ].…”

Section: Comorbidity and Pathophysiologymentioning

confidence: 91%

“…Excessive mucus production in the nasal and sinus cavities causes the feeling of sinus pressure and pain [ 64 ]. The late phase of allergic reaction occurs 4 to 8 h after exposure to an allergen and is associated with constitutional symptoms such as fatigue, malaise, headache, and irritability [ 57 , 64 , 66 , 67 ].…”

Section: Comorbidity and Pathophysiologymentioning

confidence: 99%

Allergic Rhinitis and Chronic Daily Headaches: Is There a Link?

Gryglas

2016

Curr Neurol Neurosci Rep

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Allergic rhinitis and migraine remain on the list of the most common diseases affecting adults. Migraines and headaches due to allergic rhinitis are easily confused because the symptoms of both conditions often overlap. Both may occur with sinus headache, nasal congestion, and lacrimation and may worsen with weather changes and exposure to allergens. No precise clinical definition exists for what constitutes a sinus headache, which has always been a diagnostic dilemma. Contrary to popular belief, headache is not a typical symptom of rhinitis. Some studies have shown that up to 90 % of sinus headaches are actually migraines. Nevertheless, patients with self-diagnosed sinus headache self-treat or are treated by primary care physicians and/or otolaryngologists with medications for rhinosinusitis, ignoring the neurogenic causes of the symptoms when most of these patients fulfill diagnostic criteria for chronic migraine. Chronic migraine affects 2 % of the general population and has a significant socioeconomic impact on society, incurring health care costs and diminishing quality of life; therefore, the proper diagnosis and treatment of these headache patients should be a priority.

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Prevalence of migraine headaches in patients with allergic rhinitis

Cited by 82 publications

References 31 publications

Triamcinolone Acetonide versus Fluticasone Propionate in the Treatment of Perennial Allergic Rhinitis: A Randomized, Parallel-Group Trial

Triamcinolone Acetonide versus Fluticasone Propionate in the Treatment of Perennial Allergic Rhinitis: A Randomized, Parallel-Group Trial

Physical Comorbidity of Migraine and Other Headaches in US Adolescents

Allergic Rhinitis and Chronic Daily Headaches: Is There a Link?

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