Prevalence of Metabolically Healthy Obesity (MHO) and its relation with incidence of metabolic syndrome, hypertension and type 2 Diabetes amongst individuals aged over 20 years in Ahvaz: A 5 Year cohort Study (2009–2014)

Latifi, Seyed Mahmoud; Karandish, Majid; Shahbazian, Hajieh; taha, Jalaly Mohammad; Cheraghian, Bahman; Moradi, Mitra

doi:10.1016/j.dsx.2017.07.036

Cited by 25 publications

(26 citation statements)

References 17 publications

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“…Except for the Iran study, results from Chinese, Korean and Japanese studies were consistent. However, the sample size of the Iran study was small (n 591) and the study might not have enough statistical power to test the significant difference (12) . The Taiwan study reported each 1 kg/m 2 gain of BMI associated with an 18 % increase in risk of hypertension in 1547 men and women (age range 18-59 years) who were free of the metabolic syndrome components except for WC criteria (17) .…”

Section: Discussionmentioning

confidence: 99%

“…However, previous studies were mainly based on Asian populations and focused on metabolically healthy general obesity (MHGO), defined by BMI, but overlooked metabolically healthy abdominal obesity (MHAO), defined by waist circumference (WC), which is also closely associated with hypertension (10,11) . Studies from Iran and Switzerland showed no significant association of MHO and hypertension (12,13) . Another major issue is that studies used different MHO definitions when estimating the associated hypertension risk, so comparing existing data is difficult (9) .…”

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confidence: 90%

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Metabolically healthy general and abdominal obesity are associated with increased risk of hypertension

Zhao

Qin

Sun³

et al. 2019

Br J Nutr

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Metabolically healthy obesity refers to a subset of obese people with a normal metabolic profile. We aimed to explore the association between metabolically healthy and obesity status and risk of hypertension among Chinese adults from The Rural Chinese Cohort Study. This prospective cohort study enrolled 9137 Chinese adults without hypertension, type 2 diabetes or treatment for lipid abnormality at baseline (2007–2008) and followed up during 2013–2014. Modified Poisson regression models were used to examine the risk of hypertension by different metabolically healthy and obesity status, estimating relative risks (RR) and 95 % CI. During 6 years of follow-up, we identified 1734 new hypertension cases (721 men). After adjusting for age, sex, smoking and other confounding factors, risk of hypertension was increased with metabolically healthy general obesity (MHGO) defined by BMI (RR 1·75, 95 % CI 1·02, 3·00) and metabolically healthy abdominal obesity (MHAO) defined by waist circumference (RR 1·51, 95 % CI 1·12, 2·04) as compared with metabolically healthy non-obesity. The associations between metabolically healthy and obesity status and hypertension outcome were consistent after stratifying by sex, age, smoking, alcohol drinking and physical activity. Both MHGO and MHAO were associated with increased risk of hypertension. Obesity control programmes should be implemented to prevent or delay the development of hypertension in rural China.

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Section: Discussionmentioning

confidence: 99%

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confidence: 90%

Metabolically healthy general and abdominal obesity are associated with increased risk of hypertension

Zhao

Qin

Sun³

et al. 2019

Br J Nutr

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“…Elevated fasting glucose (drug treatment of elevated glucose is an alternate indicator): ≥100 mg/dL. MHO was considered as absence of MetS and with obesity [23]. Metabolically healthy non-obese (MHNO) was diagnosed as those without MetS and obesity.…”

Section: De Nitionmentioning

confidence: 99%

“…First, due to the lack of uniform criteria of metabolic healthy obesity, the rate of metabolic healthy obesity might have varied results which make the conclusion has bias. However, in the present study, we chose the relatively widely used de nition [23]. Second, the calculation of eGFR was based on a single assessment of blood pressure which might introduce bias.…”

Section: Limitationmentioning

confidence: 99%

Metabolic Healthy Obesity is associated with higher incidence of mild decrease estimate glomerular rate in rural Northeast Chinese

Guo

et al. 2020

Preprint

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Background Metabolic healthy obesity (MHO), as one phenotype of obesity, seems associate with lower risk of cardiovascular disease. However, MHO has close relationship with higher incidence of metabolic syndrome and diabetes. This study aims to investigate the prevalence of MHO at baseline, changes of obese metabolic phenotype at follow-up and its relationship with incidence of mildly reduced estimated glomerular filtration rate (eGFR) in rural Northeast Chinese. Methods The Chronic Kidney Disease Epidemiology (CKD-EPI) equation was used to calculate eGFR. 4903 participants aged ≥ 35 years with eGFR > 90 ml/min/1.73 m2 at baseline were enrolled and successfully followed up. All participants completed the questionnaires, anthropometric measurements, and blood test during baseline and follow-up. Mild renal dysfunction defined as mildly reduced eGFR between 60–90 ml/min/1.73 m2. Results The prevalence of MHO was 20.04% in baseline (18.97% for women and 21.11% for men) which was secondary to metabolic abnormal obesity (MAO) (24.4%, 27.2% for women and 21.5% for men). 38.4% of women and 38.90% of men experienced phenotype changes during follow-up. The cumulative incidence of mildly reduced eGFR in MHO was 20.1% (17.7% for women and 22.3% for men) which was also secondary to MAO (20.8%, 18.6% for women and 23.5% for men). After adjusted possible confounders, MHO was associated with higher incidence of mildly reduced eGFR among women [OR (95%CI) = 1.64 (1.18, 2.25)] and men [OR (95%CI) = 1.62 (1.24, 2.11)] whereas MAO was related with higher incidence of mildly reduced eGFR among men only [OR (95%CI) = 1.74 (1.32, 2.29)]. Conclusion MHO was associated with higher incidence of mildly reduced eGFR in both gender; however, there was a specific relationship between MAO and mildly reduced eGFR in men only. Therefore, it is necessary to monitoring kidney function among both MHO and MAO subjects.

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“…Murcia is highlighted as the region in which obesity and overweight are most prevalent (Fernandez‐Ruiz, Paniagua‐Urbano & Sole‐Agusti, ; Aranceta‐Bartrina, Pérez‐Rodrigo, Alberdi‐Aresti, Ramos‐Carrera, & Lázaro‐Masedo, ). Overweight and obesity are related to a large amount of pathologies (Aleksandrova, Mozaffarian, & Pischon, ; Calderone et al, ; Latifi et al, ; Pavelka, ; Şahin, Naz, Varol, & Kömürcüoğlu, ), as well as to an increased risk of cardiovascular disease (Scherbaum et al, ).…”

Section: Introductionmentioning

confidence: 99%

Short‐medium‐long‐term efficacy of interdisciplinary intervention against overweight and obesity: Randomized controlled clinical trial

Fernández-Ruiz

Armero-Barranco

Paniagua-Urbano

et al. 2018

Int J of Nursing Practice

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Prevalence of Metabolically Healthy Obesity (MHO) and its relation with incidence of metabolic syndrome, hypertension and type 2 Diabetes amongst individuals aged over 20 years in Ahvaz: A 5 Year cohort Study (2009–2014)

Cited by 25 publications

References 17 publications

Metabolically healthy general and abdominal obesity are associated with increased risk of hypertension

Metabolically healthy general and abdominal obesity are associated with increased risk of hypertension

Metabolic Healthy Obesity is associated with higher incidence of mild decrease estimate glomerular rate in rural Northeast Chinese

Short‐medium‐long‐term efficacy of interdisciplinary intervention against overweight and obesity: Randomized controlled clinical trial

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