Prevalence of metabolic syndrome in Japanese psoriasis patients

Takahashi, Hidetoshi; Takahashi, Ichiro; Honma, Masaru; Ishida‐Yamamoto, Akemi; Iizuka, Hajime

doi:10.1016/j.jdermsci.2009.11.002

Cited by 57 publications

(63 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Again, we saw no link to disease severity, age at onset, presence of joint disease or presence of systemic medication. Some authors found low HDL cholesterol levels [47,49,50,51,52]. On the other hand, it is interesting to note that Mallbris et al [20] found high HDL cholesterol levels in their patients with Ps.…”

Section: Discussionmentioning

confidence: 99%

Psoriasis Vulgaris with or without Arthritis and Independent of Disease Severity or Duration Is a Risk Factor for Hypercholesterolemia

Santos‐Juanes

Coto-Segura²,

Fernández‐Vega³

et al. 2015

Dermatology

View full text Add to dashboard Cite

Background: Psoriasis (Ps) has been associated with an increased incidence of cardiovascular disease. Interesting epidemiological evidence suggests associations between Ps and dyslipidemia (DL), a well-established risk factor for cardiovascular disease. Objective: This study aimed to investigate the association between Ps and multiple measurements of DL, which include levels of triglycerides (TGs), low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and total cholesterol (TCh). We also studied the relationship between DL and disease duration. Methods: A prospective hospital-based study was conducted. A total of 661 Caucasian patients with chronic plaque Ps and 661 sex- and age-matched controls were enrolled. Results: Multivariate analysis showed that in psoriatic patients the odds ratio (OR) of TCh >200 mg/dl was 1.406 (95% confidence interval 1.115-1.173), the OR of LDL cholesterol >130 mg/dl was 1.375 (95% confidence interval 1.088-1.738), the OR of HDL cholesterol <40 mg/dl was 0.881 (95% confidence interval 0.599-1.297), and the OR of TGs >150 mg/dl was 1.041 (95% confidence interval 0.783-1.385). We did not find a relationship between lipid levels and disease duration. Conclusion: Based on our population Ps is associated with alterations in TCh and LDL cholesterol, but not in TGs and HDL cholesterol, when ATP III panel levels are used. These alterations are not related to disease duration.

show abstract

Section: Discussionmentioning

confidence: 99%

Psoriasis Vulgaris with or without Arthritis and Independent of Disease Severity or Duration Is a Risk Factor for Hypercholesterolemia

Santos‐Juanes

Coto-Segura²,

Fernández‐Vega³

et al. 2015

Dermatology

View full text Add to dashboard Cite

show abstract

“…[17] Since then, there have been many studies from various parts of the world showing the same findings. [1819]…”

Section: Discussionmentioning

confidence: 99%

Prevalence of metabolic syndrome in south Indian patients with psoriasis vulgaris and the relation between disease severity and metabolic syndrome: A hospital-based case-control study

Madanagobalane

Anandan

2012

Indian J Dermatol

View full text Add to dashboard Cite

Background:Psoriasis is a chronic inflammatory disease of the skin and joints with an increased cardiovascular risk. Previous studies have shown a higher prevalence of metabolic syndrome (MS) in psoriatic patients.Objective:To investigate the prevalence of MS in patients with psoriasis and healthy controls, and to determine the relation between disease severity and the presence of MS.Materials and Methods:We performed a hospital-based case-control study on 118 adult patients with psoriasis vulgaris and 120 controls matched for age, sex and body mass index. MS was diagnosed by the presence of three or more of the South Asian Modified National Cholesterol Education Program's Adult Panel III criteria.Results:MS was significantly more common in psoriatic patients than in controls (44.1% vs. 30%, P value = 0.025). Psoriatic patients also had a higher prevalence of triglyceridemia (33.9% vs. 20.8%, P value = 0.011), abdominal obesity (34.7% vs. 32.5%, P value = 0.035) and elevated blood sugar. There was no difference in the high density lipoprotein (HDL) levels and presence of hypertension among patients with psoriasis and normal controls. There was no correlation between the severity and duration of psoriasis with MS.Conclusion:MS is frequent in patients with psoriasis. We have found no relationship between disease severity and presence of MS. Hence, we suggest that all patients must be evaluated for the MS, irrespective of the disease severity.

show abstract

“…Large number of studies in Western literature suggests association of psoriasis with MS comprising obesity, heart disease, hyperglycemia, dyslipidemia and hypertension. [47,48] It has been recognized to contribute to the mortality risk in this group of patients. [49,50] There are no Indian studies to elucidate the role of MS in Indian patients.…”

Section: Associationsmentioning

confidence: 99%