Prevalence of metabolic syndrome in south Indian patients with psoriasis vulgaris and the relation between disease severity and metabolic syndrome: A hospital-based case-control study

Abstract

Background:Psoriasis is a chronic inflammatory disease of the skin and joints with an increased cardiovascular risk. Previous studies have shown a higher prevalence of metabolic syndrome (MS) in psoriatic patients.Objective:To investigate the prevalence of MS in patients with psoriasis and healthy controls, and to determine the relation between disease severity and the presence of MS.Materials and Methods:We performed a hospital-based case-control study on 118 adult patients with psoriasis vulgaris and 120 controls matched for age, sex and body mass index. MS was diagnosed by the presence of three or more of the South Asian Modified National Cholesterol Education Program's Adult Panel III criteria.Results:MS was significantly more common in psoriatic patients than in controls (44.1% vs. 30%, P value = 0.025). Psoriatic patients also had a higher prevalence of triglyceridemia (33.9% vs. 20.8%, P value = 0.011), abdominal obesity (34.7% vs. 32.5%, P value = 0.035) and elevated blood sugar. There was no difference in the high density lipoprotein (HDL) levels and presence of hypertension among patients with psoriasis and normal controls. There was no correlation between the severity and duration of psoriasis with MS.Conclusion:MS is frequent in patients with psoriasis. We have found no relationship between disease severity and presence of MS. Hence, we suggest that all patients must be evaluated for the MS, irrespective of the disease severity.

Risk factors for comorbidities in Czech psoriatic patients: Results of a hospital-based case-control study

“…Despite the expectations arising from the published results of a number of studies 18,29,30 , a higher level of glycemia was not found in patients with psoriasis in our study.…”

Metabolic syndrome in patients with chronic plaque psoriatic disease: a case-control study from western Uttar Pradesh, India

“…18 Two studies from South India observed a significantly higher triglyceride levels in psoriasis patients compared to controls without any significant difference in HDL levels. 9,16 Observations of Lakshmi S et al are contradictory in this aspect. She observed a higher average triglyceride level among the patients compared to controls, even though it was not statistically significant.…”

“…This figure is almost at par with findings of various other Indian and overseas studies. [9][10][11][12] Another study from Korea found the prevalence of metabolic syndrome in patients older than 53 years age. 13 Another hospital-based study found metabolic syndrome in psoriasis was more common after 40 years of age.…”

A Pattern of comorbidities in psoriasis patients from western India and the relation between disease severity and systemic comoridities: cross sectional study at a tertiary care centre

“…Biometric data such as weight, height, waist circumference were noted. Waist circumference was measured at the highest level of the iliac crest [3]]. Investigations included complete blood count (hemoglobin, total count, differential count, platelet count), C reactive protein, erythrocyte sedimentation rate, urine routine and microscopic examination, liver function tests, renal function tests, serum total protein and albumin, serum calcium, lipid profile, blood sugar estimation, thyroid function tests, ultrasound abdomen..…”