Prevalence of metabolic syndrome and its association with lifestyle and cardiovascular biomarkers among postmenopausal women in western Algeria

Khalfa, Ali; Tiali, Amina; Zemour, L.; Fatah, Azzedine; Mekki, Khedidja

doi:10.1002/ijgo.12206

Cited by 17 publications

(10 citation statements)

References 22 publications

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“…Evidence indicates that elevated body fat and hypertension are responsible for increased oxidative stress in elderly persons. 36,37 So far, it should be noted that, there have not been reports documenting healthy elderly persons only with insulin-resistance and higher damage oxidative marker (TBARS) which correlates negatively with age. Moreover, it is particularly interesting that our investigated elderly population had higher TBARS in insulin-sensitive ones.…”

Section: Discussionmentioning

confidence: 99%

Are insulin-resistance and oxidative stress cause or consequence of aging

Dzięgielewska-Gęsiak

Stołtny

Brożek

et al. 2020

Exp Biol Med (Maywood)

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Insulin resistance (IR) may be associated with oxidative stress and leads to cardiovascular disorders. Current research focuses on interplay between insulin-resistance indices and oxidant-antioxidant markers in elderly individuals with or without insulin-resistance. The assessment involved anthropometric data (weight, height, BMI, percentage of body fat (FAT)) and biochemical tests (glucose, lipids, serum insulin and plasma oxidant-antioxidant markers: Thiobarbituric Acid-Reacting Substances (TBARS), Cu,Zn-superoxide dismutase (SOD-1) and total antioxidant status). Insulin resistance index (IR) assuming a cut-off point of 0.3 allows to divides groups into: insulin sensitive group (InsS) IR < 0,3 ( n = 35, median age 69.0 years) and insulin-resistant group (InsR) IR ≥ 0.3 ( n = 51, median age 71.0 years). Lipids and antioxidant defense system markers did not differentiate the investigated groups. In the InsR elderly group, the FAT was increased ( P < 0.000003) and TBARS ( P = 0.008) concentration decreased in comparison with InsS group. A positive correlation for SOD-1 and total antioxidant status ( P < 0.05; r = 0.434) and a negative correlation for TBARS and age ( P < 0.05 with r = −0.421) were calculated in InsR individuals. In elderly individuals, oxidative stress persists irrespective of insulin-resistance status. We suggest that increased oxidative stress may be consequence of old age. An insulin action identifies those at high risk for atherosclerosis, via congruent associations with oxidative stress and extra- and intra-cellular antioxidant defense systems. Thus, we maintain that insulin-resistance is not the cause of aging. Impact statement Insulin resistance is associated with oxidative stress leading to cardiovascular diseases. However, little research has been performed examining elderly individuals with or without insulin-resistance. We demonstrate that antioxidant defense systems alone is not able to abrogate insulin action in elderly individuals at high risk for atherosclerosis, whereas the combined oxidant-antioxidant markers (thiobarbituric acid-reacting substances (TBARS), Cu,Zn-superoxide dismutase (SOD-1), and total antioxidant status (TAS)) might be more efficient and perhaps produce better clinical outcome. In fact, a decrease in oxidative stress and strong interaction between antioxidant defense can be seen only among insulin-resistant elderly individuals. This is, in our opinion, valuable information for clinicians, since insulin-resistance is considered strong cardiovascular risk factor.

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Section: Discussionmentioning

confidence: 99%

Are insulin-resistance and oxidative stress cause or consequence of aging

Dzięgielewska-Gęsiak

Stołtny

Brożek

et al. 2020

Exp Biol Med (Maywood)

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“…Similarly to our findings, these authors observed no differences in HDL, fasting glucose levels and hs-CRP. Prior reports from other populations have observed changes in lipid profiles and a high prevalence of metabolic syndrome among postmenopausal women [7]. The large study by Auro et al [27] found some lipid markers, including VLDL-c and LDL-c, to be predictors of menopause status.…”

Section: Discussionmentioning

confidence: 99%

“…Obesity is a well-known risk factor for both CVD and cancer, being also more prevalent in postmenopausal women [4–6]. In this context, several biomarkers of metabolic risk have been evaluated in postmenopausal women, attempting to explain the epidemiologic connection between menopause and CVD [7]; however, laboratory findings observed remain widely controversial.…”

Section: Introductionmentioning

confidence: 99%

Hormonal, metabolic and inflammatory circulating biomarker profiles in obese and non-obese Brazilian middle-aged women

et al. 2019

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To investigate circulating hormonal, metabolic and inflammatory biomarker profiles in obese and non-obese middle-aged women. Methods A total of 110 women, aged 40-60 years, were included in this cross-sectional study. Patients were allocated, according to the occurrence of menopause and body mass index (BMI), into four groups: PM0 (premenopausal non-obese), PM1 (premenopausal obese), M0 (postmenopausal non-obese), and M1 (postmenopausal obese). Serum levels of gonadotropins, sex hormones, lipid markers, leptin, hs-CRP and interleukin-6 were obtained using either colorimetric or immunoenzymatic assays. Univariate and correlation analyses were performed among all clinical and laboratorial parameters. Principal component analysis was used to characterize subsets of biomarkers, which had their discriminatory capacity tested using discriminant function analysis. Results Levels of gonadotropins and female sex hormones were similar between PM0 and PM1 and between M0 and M1 (p > 0.05), all of them varied between PM0 and M0 (p < 0.05), but only estradiol was significantly altered in the comparison between PM1 and M1 (p = 0.027). Regarding metabolic markers, leptin was lower in PM0 than in M0 (p = 0.010) and higher in M1 than in M0 (p = 0.046). In premenopausal women, BMI correlated only to leptin, while it correlated to several other markers in postmenopausal women. A combination of FSH and leptin serum levels significantly discriminated the four groups (Wilks's lambda < 0.001, in canonical functions 1 and 2).

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“…Menopause is a result of aging, which essentially means that the ovaries are no longer ovulating or producing very few sex hormones [ 11 , 12 ]. Clinically, natural menopause is defined as a 1-year period of amenorrhea following the final menstrual period (FMP) without any pathological or physiological cause [ 13 , 14 ].…”

Section: Definition Of Menopause and Metabolic Disordersmentioning

confidence: 99%

Metabolic Disorders in Menopause

Jeong

Park²

2022

Metabolites

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Menopause is an aging process and an important time equivalent to one-third of a woman’s lifetime. Menopause significantly increases the risk of cardiometabolic diseases, such as obesity, type 2 diabetes, cardiovascular diseases, non-alcoholic liver disease (NAFLD)/metabolic associated fatty liver disease (MFFLD), and metabolic syndrome (MetS). Women experience a variety of symptoms in the perimenopausal period, and these symptoms are distressing for most women. Many factors worsen a woman’s menopausal experience, and controlling these factors may be a strategy to improve postmenopausal women’s health. This review aimed to confirm the association between menopause and metabolic diseases (especially MetS), including pathophysiology, definition, prevalence, diagnosis, management, and prevention.

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Prevalence of metabolic syndrome and its association with lifestyle and cardiovascular biomarkers among postmenopausal women in western Algeria

Abstract: Postmenopausal status could predict MetS, with inflammation and oxidative stress arising from an unhealthy lifestyle potentially increasing cardiovascular risk.

Cited by 17 publications

References 22 publications

Are insulin-resistance and oxidative stress cause or consequence of aging

Are insulin-resistance and oxidative stress cause or consequence of aging

Hormonal, metabolic and inflammatory circulating biomarker profiles in obese and non-obese Brazilian middle-aged women

Metabolic Disorders in Menopause

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