Prevalence of memory loss complaints and other symptoms associated with the menopause transition: A community survey

Devi, Gayatri; Hahn, Katherine; Massimi, Stephen; Zhivotovskaya, Emiliya

doi:10.1016/s1550-8579(05)80055-5

Cited by 23 publications

(18 citation statements)

References 18 publications

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“…This lack of association is in agreement with other studies 1,5,7 , although a general population study by Devi and colleagues 35 reported that perimenopausal and menopausal women had a higher incidence of memory problems than premenopausal women. They concluded that memory problems form part of the symptom complex of the menopausal transition.…”

Section: Discussionsupporting

confidence: 92%

Subjective cognitive complaints at menopause associated with declines in performance of verbal memory and attentional processes

2010

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Section: Discussionsupporting

confidence: 92%

Subjective cognitive complaints at menopause associated with declines in performance of verbal memory and attentional processes

2010

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“…The participants were concerned about forgetfulness. Complains about memory loss and cognitive abilities occurs during the transitional period from premenopausal period to menopause (30, 31). Forgetfulness has a negative effect on the quality of life (32).…”

Section: Discussionmentioning

confidence: 99%

Perceived Concerns of Azeri Menopausal Women in Iran

Hakimi

Simbar

Tehrani

2014

Iran Red Crescent Med J

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Background:Menopause is a complex biological phenomenon which is affected by socio-cultural and physiological factors. These factors may cause different experiences and concerns for menopausal women from different countries and even among women of diverse ethnic groups living in the same country. The signs and symptoms of menopause are exacerbated by the negative attitude of menopausal women and their deep concerns.Objectives:We aimed to explore self-experienced concerns of Iranian menopausal women residing in Tabriz.Materials and Methods:Phenomenological approach was used for analyzing the participants’ experiences and perceptions about menopause. Data were collected through 18 semi-structured in-depth interviews; carried out from February to July 2012. Participants were menopausal women aged between 46-57 years who experienced menopause no more than 4 years before the interview. All interviews were audio recorded and transcribed verbatim. Constant comparative analysis of the data was conducted using MAXQDA 10.Results:Participants’ concerns were classified into 4 main themes, including: inability, aging, isolation, and healthiness.Conclusions:Understanding these concerns might contribute to the enrichment of the existing literature by providing evidences from a different culture, assisting to design effective supportive strategies, planning training programs and appropriate infrastructures for women to improve their quality of life during the menopausal period.

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“…Similar findings are reported for humans after surgical ovariectomy (Moller et al, 2010; Sherwin, 1988). Results for women in menopause are less clear but careful studies suggest that measurable declines in learning scores occur in this case as well (Vearncombe et al, 2011; Devi et al, 2005; Wegesin and Stern, 2007). The question thus arises as to whether long term depletion of estrogen negatively affects the LTP-related actin signaling systems that are driven by acute administrations.…”

Section: Significance For Conditions In Which Estrogen Levels Are mentioning

confidence: 99%

Estrogen promotes learning-related plasticity by modifying the synaptic cytoskeleton

et al. 2013

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Estrogen's acute, facilitatory effects on glutamatergic transmission and long-term potentiation (LTP) provide a potential explanation for the steroid's considerable influence on behavior. Recent work has identified mechanisms underlying these synaptic actions. Brief infusion of 17β-estradiol (E2) into adult male rat hippocampal slices triggers actin polymerization within dendritic spines via a signaling cascade beginning with the GTPase RhoA and ending with inactivation of the filament severing protein cofilin. Blocking this sequence, or actin polymerization itself, eliminates E2's effects on synaptic physiology. Notably, the theta burst stimulation used to induce LTP activates the same signaling pathway as E2 plus events that stabilize the reorganization of the sub-synaptic cytoskeleton. These observations suggest that E2 elicits a partial form of LTP, resulting in an increase of fast EPSP's and a reduction in the threshold for lasting synaptic changes. While E2's effects on the cytoskeleton could be direct, results described here indicate that the hormone activates synaptic TrkB receptors for Brain Derived Neurotrophic Factor, a releasable neurotrophin that stimulates the RhoA to cofilin pathway. It is therefore possible that E2 acts via transactivation of neighboring receptors to modify the composition and structure of excitatory contacts. Finally, there is the question of whether a loss of acute synaptic actions contributes to the memory problems associated with estrogen depletion. Initial tests found that ovariectomy in middle-aged rats disrupts RhoA signaling, actin polymerization, and LTP consolidation. Acute applications of E2 reversed these defects, a result consistent with the idea that disturbances to actin management are one cause of behavioral effects that emerge with reductions in steroid levels.

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Prevalence of memory loss complaints and other symptoms associated with the menopause transition: A community survey

Cited by 23 publications

References 18 publications

Subjective cognitive complaints at menopause associated with declines in performance of verbal memory and attentional processes

Subjective cognitive complaints at menopause associated with declines in performance of verbal memory and attentional processes

Perceived Concerns of Azeri Menopausal Women in Iran

Estrogen promotes learning-related plasticity by modifying the synaptic cytoskeleton

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