Prevalence of Maternal Genital Tract Colonization by Group B Streptococcus From Western Province, Taif, Saudi Arabia

Arain, Farzana Rizwan; Albezrah, Nisreen Aref; Ali, Khadija Yosif

doi:10.14740/jcgo341w

Cited by 9 publications

(13 citation statements)

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“…Similarly, during the same period in Kuwait, resistance to erythromycin and clindamycin was (12.6%) and (7.0%), respectively [30]. Even significantly lower resistance (0.18%) to clindamycin with no resistance to erythromycin was reported in a previous study performed in Taif, Saudi Arabia [18]. These findings indicate an increase in the resistance both to erythromycin and clindamycin, which is likely related to antibiotic administration according to individual institutional policies rather than to an adopted national policy.…”

Section: Group B Streptococcus In Saudi Pregnant Womensupporting

confidence: 58%

“…As both studies were carried out at the same hospital, these results indicate an increase in the GBS colonization rate among pregnant women in Makkah. Wide geographic variations in the rates of GBS maternal colonization were documented in Saudi Arabia, with higher GBS colonization rates ranging from 19% to 31.6% in Dammam, Taif, Riyadh, and Jeddah [17][18][19][20][21].…”

Section: Discussionmentioning

confidence: 99%

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Group B streptococcus colonization, antibiotic susceptibility, and serotype distribution among Saudi pregnant women

Khan

Faiz

et al. 2020

Infect Chemother

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Background: Group B Streptococcus (GBS) comprises the normal flora of the female urogenital tract and can be transferred to neonates during delivery, causing invasive diseases. This study was performed to investigate the colonization rate, antibiotic susceptibility, and serotype of GBS among Saudi pregnant women. Materials and Methods: In this cross-sectional study, vagino-rectal swabs from 400 pregnant women were collected over a period of one year. Identification of GBS isolates and determination of their antibiotic susceptibility were performed using the Microscan Walk Away system. The isolates were then typed using both latex agglutination and capsular genebased multiplex polymerase chain reaction assays. Results: Sixty (15.0%) subjects were colonized by GBS, with serotype Ia as the dominant type (30.0%) followed by serotype III and V (25.0%, each). Only 43 (71.7%) isolates were typed by latex agglutination, whereas the remaining isolates were not typable or were non-specifically typed as compared to the genotyping assay, which revealed the specific type of each GBS isolate. The highest resistance rates were observed for erythromycin and clindamycin (16.7%, each), which were mainly restricted to the prevalent serotypes. Conclusion: This study is the first to report the distribution of GBS serotypes based on molecular genotyping in Saudi Arabia. GBS colonization was evident among pregnant women, and resistance to erythromycin and clindamycin was predominant among serotypes Ia, III, and V. Molecular genotyping using capsular gene-based multiplex PCR provided reliable typing of the investigated GBS isolates in terms of sensitivity and specificity as compared to conventional serotyping using latex agglutination.

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Section: Group B Streptococcus In Saudi Pregnant Womensupporting

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Group B streptococcus colonization, antibiotic susceptibility, and serotype distribution among Saudi pregnant women

Khan

Faiz

et al. 2020

Infect Chemother

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“…Gestational age did not influence the rates of maternal colonization with GBS among HIV-1-infected women [26]. GBS colonization was found associated with age, occupation, number of antenatal clinic visits, and gravida [3]. In contrast there were no significant differences between colonized and GBSnegative women with regard to age, marital status, previous miscarriages or abortions, gestational age at examination or at delivery, rate of prematurity, infant's birth weight, or mode of delivery [20].…”

Section: Discussionmentioning

confidence: 84%

“…It is also implicated in adverse pregnancy outcomes [2]. Maternal colonization has been found to be a major risk factor for invasive neonatal GBS disease within 6 days of birth [3]. In more than 80% of these cases, neonatal GBS infection is acquired during pregnancy and delivery by direct mother to child transmission of the pathogen.…”

Section: Introductionmentioning

confidence: 99%

Risk Factors Associated with Group B Streptococcus Colonization and Their Effect on Pregnancy Outcome

Lekala

Mavenyengwa

Moyo

et al. 2015

JGO

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“…In Saudi Arabia, available recorded data about S. agalactiae group Bantimicrobial susceptibility were obtained from studies performed in different governorates 12,13,15,19,20 . In this investigation, the general occurrence of GBS colonization amongst pregnant ladies was observed to be 10.4%.…”

Section: Discussionmentioning

confidence: 99%

Correlation Between Strain Distribution and Antibiotic Resistance Genes Pattern of Streptococcus agalactiae Group B from Patients in Taif, Saudi Arabia

Felemban¹,

Juaid²,

Alsanie³

et al. 2019

J Pure Appl Microbiol

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The Group B Streptococcus (Streptococcus agalactiae) (GBS) is one of the natural flora bacteria in the female reproductive system. In the recent years, GBS has become the major bacterial infections throw the perinatal period causing many troubles. This study was undertaken to determine the prevalence and antibiotic genes of GBS colonization in pregnant women of obstetrics hospital in Taif, Saudi Arabia. Fourteen Streptococcus agalactiae isolates obtained after screening about 134 swabs samples from genitourinary tract specimens of women patients from obstetrics hospital in Taif governorate, Saudi Arabia. These isolates were studied for antibiotic resistance and virulence genes. All obtained isolates were identified as Streptococcus agalactiae by the 16S rDNA gene sequence. These strains were found by Disc diffusion method sensitive against Meropenem, Cefotaxime, Cefepime, Amoxicillin, Penicillin G, Daptomycin, Chloramphenicol, Linezolid and Levofloxacin. The highest resistance was for Tetracyclin (85.7%) whereas the lowest resistance was found for Vancomycin (21.4%). Resistance against Erythromycin and Clindamycin was 71.5%, and 28.5% respectively. PCR based detection revealed 50% of isolates were carrying the tetT genes, while 92.8% of isolates were carrying tetO and tetM genes associated with Tetracycline resistance. All isolates were harboring genes that associated with Erythromycin resistance like ErmB1, ErmB2, and Erm(A|TR) genes, but only 28.5% of isolates were carrying ErmTR gene. Molecular detection of virulence associated genes revealed that out of fourteen isolates of S. agalactiae, only one isolate was carrying the LinB gene, while all isolates were positive for MreA and VanA genes respectively. We can conclude that the GBS isolates were found sensitive to many antibiotic while most isolates were resistance to Tetracycline due to the existence of tetO and tetM genes. Resistance against Erythromycin and Clindamycin was 71.5%, and 28.5% respectively. The two erythromycin resistance genes (ErmB and ErmTR) were found in all isolates, while, the third erythromycin resistance gene Erm(A|TR) was found only in 25.8% of the isolates.

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Prevalence of Maternal Genital Tract Colonization by Group B Streptococcus From Western Province, Taif, Saudi Arabia

Cited by 9 publications

References 0 publications

Group B streptococcus colonization, antibiotic susceptibility, and serotype distribution among Saudi pregnant women

Group B streptococcus colonization, antibiotic susceptibility, and serotype distribution among Saudi pregnant women

Risk Factors Associated with Group B Streptococcus Colonization and Their Effect on Pregnancy Outcome

Correlation Between Strain Distribution and Antibiotic Resistance Genes Pattern of Streptococcus agalactiae Group B from Patients in Taif, Saudi Arabia

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