Prevalence of Malaria Infection and Reliability of ACCUCARE One Step Malaria Test® for Diagnosing Malaria in People Living with Human Immunodeficiency Virus Infection in Cameroon

Kamgain, Lugarde Mawabo; Assam-Assam, Jean-Paul; Foko, Loick Pradel Kojom; Fouamno, Henri Lucien Kamga

doi:10.9734/ijtdh/2017/30277

Cited by 9 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Predictors of urinary tract infection found in the study have been used for defining diagnosis algorithms and their diagnosis performances were then evaluated. Parameters of diagnosis performances were computed as described by [12]. These consisted of sensitivity (Se), specificity (Sp), positive predictive value (PPV), negative predictive value (NPV), accuracy and kappa index.…”

Section: Discussionmentioning

confidence: 99%

Predictors of Urinary Tract Infection and Their Diagnostic Performances among Cameroonian Under-five

Motse¹,

Ngaba²,

Kojom³

et al. 2019

Journal of Microbiology and Infectious Diseases

View full text Add to dashboard Cite

Objective: Urinary tract infection (UTIs) in child is a serious public health problem especially in developing countries. This study aimed at identifying factors associated with urinary tract infection and determining their diagnosis performances as well as resulting algorithms among Cameroonian under-five. Methods: A descriptive and analytical cross sectional study took place from May 2013 to March 2014 at Pediatrics Department of the Bonassama District hospital in the town of Douala. Urine samples were collected dependent on the age of children and its aptitude to micturate. Ten microliters (10 µL) of urine specimen were cultured at 37°C for 24-48 hours. In addition, sociodemographic, anthropometric, clinic and biological information of each child were documented. Results: The prevalence of UTI was 32.2% (129/400) which was mainly caused by Escherichia coli (41.1%). A total of four risk factors for UTI were found after adjustment for all pertinent characteristics of children. These included female gender (ARR= 0.55; p= 0.0046), presence of fever (ARR = 1.83; p= 0.0426), trouble urine (ARR = 1.36; p= 0.0063) and presence of nitrites in urine (ARR = 1.09; p= 0.0001). Presence of nitrites was the most discriminant parameter based on specificity (98.1%), positive predictive value (95.4%) and negative predictive value (90.1%). The diagnosis performances have gradually improved with the increasing number of parameters. Conclusion: This study reported four factors associated with increased risk for UTI. This also outlined that the presence of nitrites in urine had best diagnosis performances and different predictors-based clinical algorithms could be helpful especially in the identification of UTI-negative children.

show abstract

Section: Discussionmentioning

confidence: 99%

Predictors of Urinary Tract Infection and Their Diagnostic Performances among Cameroonian Under-five

Motse¹,

Ngaba²,

Kojom³

et al. 2019

Journal of Microbiology and Infectious Diseases

View full text Add to dashboard Cite

show abstract

“…The increase in RDT usage is probably due to their easier implementation, handling and interpretation as compared with light microscopy, which has many limitations jeopardizing its utilization in certain areas [5,6]. The implementation of light microscopy is particularly challenging as it is labour-intensive and requires skilled microscopists in resource-constrained, remote and difficult-to-reach areas with no electricity [1,5,6]. As a consequence, malaria diagnosis relies mainly on signs and symptoms presented by patients in these areas [1,6].…”

Section: Introductionmentioning

confidence: 99%

“…The implementation of light microscopy is particularly challenging as it is labour-intensive and requires skilled microscopists in resource-constrained, remote and difficult-to-reach areas with no electricity [1,5,6]. As a consequence, malaria diagnosis relies mainly on signs and symptoms presented by patients in these areas [1,6]. This kind of clinical diagnosis is less sensitive and specific, especially in highly malaria-endemic areas, given other co-endemic infectious diseases may elicit a similar clinic presentation in patients [6].…”

Section: Introductionmentioning

confidence: 99%

“…As a consequence, malaria diagnosis relies mainly on signs and symptoms presented by patients in these areas [1,6]. This kind of clinical diagnosis is less sensitive and specific, especially in highly malaria-endemic areas, given other co-endemic infectious diseases may elicit a similar clinic presentation in patients [6]. In contrast, there are evidence-based reports indicating the improved management of malarious patients using RDTs [1,5,6].…”

Section: Introductionmentioning

confidence: 99%

“…This kind of clinical diagnosis is less sensitive and specific, especially in highly malaria-endemic areas, given other co-endemic infectious diseases may elicit a similar clinic presentation in patients [6]. In contrast, there are evidence-based reports indicating the improved management of malarious patients using RDTs [1,5,6]. Another study in Cameroonian children reported that the utilization of a RDT lowered the rate of anti-malarial drugs misuse in them [7].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prevalence of Plasmodium falciparum field isolates with deletions in histidine-rich protein 2 and 3 genes in context with sub-Saharan Africa and India: a systematic review and meta-analysis

Kojom

Singh

2020

Malar J

View full text Add to dashboard Cite

Background: In 2017, nearly 80% of malaria morbidity and mortality occurred in sub-Saharan African (SSA) countries and India. Rapid diagnostic tests (RDTs), especially those targeting histidine-rich protein 2 (PfHRP2) of Plasmodium falciparum, have become an important diagnostic tool in these malaria-endemic areas. However, the chances of RDToriented successful treatment are increasingly jeopardized by the appearance of mutants with deletions in pfhrp2 and pfhrp3 genes. This systematic review and meta-analysis determines the prevalence of field P. falciparum isolates with deletion in pfhrp2 and/or pfhrp3 genes and their proportion among false-negative results in the PfHRP2-based RDTs in SSA and India.Methods: Eight electronic databases were used for searching potentially relevant publications for the systematic review analysis, wherein the main methodological aspects of included studies were analysed and some missing links in the included studies were identified. Results:A total of 19 studies were included, 16 from SSA and 3 from India. The pooled prevalence of pfhrp2 deletions was 8 and 5% while 16 and 4% for pfhrp3 gene deletions in Africa and India, respectively. The pooled proportion of pfhrp2 gene deletions found among false negative PfHRP2-based RDTs results was about 27.0 and 69.0% in Africa and India, respectively. Conclusions:This review study indicates a relatively high proportion of both pfhrp2/3 genes deletions in P. falciparum isolates and among false-negative malaria cases using PfHRP2-based RDT results in SSA and India. Recently the deletions in pfhrp2/3 genes have also been reported from two African countries (Nigeria and Sudan). This review emphasizes the importance of more extensive studies and standardization of studies addressing the pfhrp2/3 gene deletions in malarious areas.

show abstract

First evidence of local circulation of Plasmodium ovale curtisi and reliability of a malaria rapid diagnostic test among symptomatic outpatients in Douala, Cameroon

Foko

Motse

Mawabo

et al. 2021

Infection, Genetics and Evolution

View full text Add to dashboard Cite

Prevalence of Malaria Infection and Reliability of ACCUCARE One Step Malaria Test® for Diagnosing Malaria in People Living with Human Immunodeficiency Virus Infection in Cameroon

Cited by 9 publications

References 0 publications

Predictors of Urinary Tract Infection and Their Diagnostic Performances among Cameroonian Under-five

Predictors of Urinary Tract Infection and Their Diagnostic Performances among Cameroonian Under-five

Prevalence of Plasmodium falciparum field isolates with deletions in histidine-rich protein 2 and 3 genes in context with sub-Saharan Africa and India: a systematic review and meta-analysis

First evidence of local circulation of Plasmodium ovale curtisi and reliability of a malaria rapid diagnostic test among symptomatic outpatients in Douala, Cameroon

Contact Info

Product

Resources

About