Prevalence of Malaria and Sexually Transmitted and Reproductive Tract Infections in Pregnancy in Sub-Saharan Africa

Chico, R Matthew; Mayaud, Philippe; Ariti, Cono; Mabey, David; Ronsmans, Carine; Chandramohan, Daniel

doi:10.1001/jama.2012.3428

Cited by 168 publications

(161 citation statements)

References 60 publications

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“…That was in Tanzania where 48.3% of RPR-positive women also had placental malarial infection. 25 In contrast, we found the prevalence of malarial and syphilis coinfection to be 10.5% based on RPR testing and peripheral parasitemia diagnosed by PCR among pregnant women at ANC booking. Malarial and syphilis coinfection based on RPR and TPHA results in this study was 4.0%.…”

Section: Discussionmentioning

confidence: 55%

“…25 This analysis also highlighted the paucity of data on the frequency of malarial and curable STI/RTI coinfection (syphilis, Chlamydia, gonorrhea, trichomoniasis, and bacterial vaginosis). 25 In the context of increasing malaria parasite resistance to SP, particularly in east and southern Africa, and the limited diagnostic precision of the syndromic management among pregnant women, new strategies to control these infections in pregnancy are needed. One option under consideration is to provide combination therapy that is safe and effective against malarial infection and curable STIs/RTIs.…”

Section: Introductionmentioning

confidence: 95%

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Malarial Infection and Curable Sexually Transmitted and Reproductive Tract Infections Among Pregnant Women in a Rural District of Zambia

Chaponda

Chico

Bruce

et al. 2016

The American Society of Tropical Medicine and Hygiene

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Abstract. Malarial infection and curable sexually transmitted and reproductive tract infections (STIs/RTIs) are important causes of adverse birth outcomes. Reducing the burden of these infections in pregnancy requires interventions that can be easily integrated into the antenatal care (ANC) package. However, efforts to integrate the control of malarial infection and curable STIs/RTIs in pregnancy have been hampered by a lack of evidence related to their coinfection. Thus, we investigated the prevalence of coinfection among pregnant women of rural Zambia. A prospective cohort study was conducted in Nchelenge District, Zambia, involving 1,086 first ANC attendees. We screened participants for peripheral malarial infection and curable STIs/RTIs (syphilis, Chlamydia, gonorrhea, trichomoniasis, and bacterial vaginosis), and collected relevant sociodemographic data at booking. Factors associated with malarial and STI/RTI coinfection were explored using univariate and multivariate regression models. Among participants with complete results (N = 1,071), 38.7% (95% confidence interval [CI] = 35.7-41.6) were coinfected with malaria parasites and at least one STI/RTI; 18.9% (95% CI = 16.5-21.2) were infected with malaria parasites only; 26.0% (95% CI = 23.5-28.8) were infected with at least one STI/RTI but no malaria parasites, and 16.4% (95% CI = 14.1-18.6) had no infection. Human immunodeficiency virus (HIV)-infected women had a higher risk of being coinfected than HIV-uninfected women (odds ratio [OR] = 3.59 [95% CI = 1.73-7.48], P < 0.001). The prevalence of malarial and STI/RTI coinfection was high in this population. An integrated approach to control malarial infection and STIs/RTIs is needed to reduce this dual burden in pregnancy.

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Section: Discussionmentioning

confidence: 55%

Section: Introductionmentioning

confidence: 95%

Malarial Infection and Curable Sexually Transmitted and Reproductive Tract Infections Among Pregnant Women in a Rural District of Zambia

Chaponda

Chico

Bruce

et al. 2016

The American Society of Tropical Medicine and Hygiene

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“…Por otro lado, Marazzo et al reportaron una prevalencia de VB de 29% en mujeres que tienen sexo con otras mujeres (18) . Mundialmente se reportan prevalencias altas en África subsahariana, tal como se muestra en un metaanálisis de más de 170 estudios, en el que la prevalencia de VB en el sur y oriente de África fue de 50,8% (43,3-58,4%), y en el centro y occidente de África fue de 37,6% (18,0-57,2%) (19) . En los EE.UU., en una muestra representativa de 3739 mujeres reclutadas durante 2001-2004 a nivel nacional, casi una de cada tres participantes (29,2%; IC 95% 27,2-31,3) tenía VB por tinción de Gram del líquido vaginal (1) .…”

Section: Discussionunclassified

Prevalencia de vaginosis bacteriana y factores asociados en veinte ciudades del Perú

Lopez-Torres

Chiappe

Cárcamo

et al. 2016

Rev Peru Med Exp Salud Publica

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“…In their study, the prevalence of vaginal chlamydia infection among pregnant women was 8% (7). In Chico et al 's study, however, chlamydia infection prevalence was 6.1% (8). Kamara et al, in a study in Jamaica, found that the prevalence of TV and BV among pregnant women was respectively 18% and 44.1%, and of those women, 30.7% were positive for Candida, too (1).…”

Section: Introductionmentioning

confidence: 87%

Prevalence study of genital tract infections in pregnant women referred to health centers in Iran

Mobasheri¹,

Varnamkhast²,

Karimi³

et al. 2014

Turk J Med Sci

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Two new bis(bidentate) azine ligands were prepared by linking (1 Z ,1 Z)-1,1 -{butane-1,4-diylbis[oxybenzene-4,1-diyl(1 Z) eth-1-yl-1-ylidene]}dihydrazine to salicylaldehyde and pyridine-2-carbaldehyde, 1,4-bis{4-and 1,4-bis{4-{(1 E) -1-((2E) -(pyridine-2-ylmethylidene)hydrazonylidene)ethyl}phenoxy}butane (L 2 ), respectively. Two kinds of copper(II) and nickel(II) complexes with different ligands were prepared. Reaction of H 2 L 1 with Cu(II) and Ni(II) acetate with 1:1 molar ratio gave double stranded binuclear bis(azine) complexes with stoichiometry [M(L 1 )] 2 containing {M II N 2 O 2 } centers. On the other hand, 1:1 molar ratio reaction of Cu(II) and Ni(II) chloride with L 2 yielded mononuclear metal complexes with general stoichiometry [M(L 2 )Cl 2 ] containing {M II N 2 N 2 } centers. The structures of both bis(azine) ligands and complexes were identified by elemental analysis, infrared spectra, UV-Vis electronic absorption spectra, magnetic susceptibility measurements, and TGA. DNA binding and DNA cleavage activities of the mononuclear complexes of L 2 , [M(L 2 )Cl 2 ] were examined by using UV-Vis titration and agarose gel electrophoresis, respectively. The results indicate that mononuclear complexes, especially [Cu(L 2) Cl 2 ], bind significantly calf thymus DNA and cleaves pBR322 DNA. Furthermore, the complexing properties of the bis-azine ligands toward selected transition metal cations and dichromate anions were also reported. It was found that bis(azine) ligands have high extraction ability towards dichromate anions.

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Prevalence of Malaria and Sexually Transmitted and Reproductive Tract Infections in Pregnancy in Sub-Saharan Africa

Cited by 168 publications

References 60 publications

Malarial Infection and Curable Sexually Transmitted and Reproductive Tract Infections Among Pregnant Women in a Rural District of Zambia

Malarial Infection and Curable Sexually Transmitted and Reproductive Tract Infections Among Pregnant Women in a Rural District of Zambia

Prevalencia de vaginosis bacteriana y factores asociados en veinte ciudades del Perú

Prevalence study of genital tract infections in pregnant women referred to health centers in Iran

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