“…8 But accumulation of data over time suggests that mutations in this gene vary geographically and mostly in accordance with the employed antimalarial regimens. [14][15][16][17][18][19][20][21] In a recent study, non-reference K13 mutations viz., 584V, 580Y, 574L, 568G, 553L, 543T, 539T, 493H, 481V, 449A, 255K, and 189T have been found involved in prolonged parasite clearance, and it was also stated that artemisinin resistance in SEA has emerged independently without sweeping from Cambodia. 22 In 2016, most of them became either validated or candidate K13 mutation for artemisinin resistance.…”