Prevalence of item level negative symptoms in first episode psychosis diagnoses

Lyne, John; O’Donoghue, Brian; Owens, Elizabeth B.; Renwick, Laoise; Madigan, Kevin; Kinsella, Anthony; Clarke, Mary; Turner, Niall; O’Callaghan, Eadbhard

doi:10.1016/j.schres.2012.01.004

Cited by 52 publications

(44 citation statements)

References 34 publications

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“…Our previous findings (Malla et al, 2004, as well as other studies have also documented that anhedonia may be the most frequent and prominent negative symptoms in patients with more severe negative symptoms (Nesvag et al 2009, Green et al, 2011, Leitman et al, 2011, Lyne et al, 2012, Stauffer et al, 2012. Recently, there has been a movement towards a two negative symptoms subdomains (Mueser et al, 1994, Blanchard and Cohen, 2006, Kimhy et al, 2006, Foussias and Remington, 2010) rather then the previously 5-construct model proposed by the MATRICS (Kirkpatrick et al, 2006).…”

Section: Discussionsupporting

confidence: 53%

Investigation of white matter abnormalities in first episode psychosis patients with persistent negative symptoms

Hovington

Bodnar

Chakravarty

et al. 2015

Psychiatry Research: Neuroimaging

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Section: Discussionsupporting

confidence: 53%

Investigation of white matter abnormalities in first episode psychosis patients with persistent negative symptoms

Hovington

Bodnar

Chakravarty

et al. 2015

Psychiatry Research: Neuroimaging

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“…Negative symptoms in schizophrenia refer to a range of deficits in both the ability to express and experience emotion and are found across the schizophrenia-spectrum, occurring in the clinical high risk (Piskulic et al, 2012), first episode (Lyne et al, 2012), and prolonged phases of the condition (Strauss et al, 2013). Negative symptoms include decrements in interest in others, paucity of thought content, avolition, blunted affect, and anhedonia, and are of particular clinical relevance given their association with a range of relatively poorer outcomes (Bowie et al, 2006;Buchanan, 2007;Möller, 2007;Hunter and Barry, 2012), unresponsiveness to pharmacotherapy (Buckley and Stahl, 2007;Barnes and Paton, 2011) but potential response to psychosocial intervention (Savill et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Metacognitive deficits predict future levels of negative symptoms in schizophrenia controlling for neurocognition, affect recognition, and self-expectation of goal attainment

Lysaker

Kukla

Dubreucq

et al. 2015

Schizophrenia Research

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“…While the core symptoms of schizophrenia are characterized by positive (e.g., delusion, hallucination) and negative (e.g., emotional withdrawal) symptoms [9], it has been believed that currently available antipsychotics work primarily on relieving positive symptoms, whereas negative symptoms are harder to treat [10-13]. The schizophrenia research community has tremendous interest in understanding the nature of negative symptoms [8,14,15]. …”

Section: Introductionmentioning

confidence: 99%

The longitudinal interplay between negative and positive symptom trajectories in patients under antipsychotic treatment: a post hoc analysis of data from a randomized, 1-year pragmatic trial

et al. 2013

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BackgroundSchizophrenia is a highly heterogeneous disorder with positive and negative symptoms being characteristic manifestations of the disease. While these two symptom domains are usually construed as distinct and orthogonal, little is known about the longitudinal pattern of negative symptoms and their linkage with the positive symptoms. This study assessed the temporal interplay between these two symptom domains and evaluated whether the improvements in these symptoms were inversely correlated or independent with each other.MethodsThis post hoc analysis used data from a multicenter, randomized, open-label, 1-year pragmatic trial of patients with schizophrenia spectrum disorder who were treated with first- and second-generation antipsychotics in the usual clinical settings. Data from all treatment groups were pooled resulting in 399 patients with complete data on both the negative and positive subscale scores from the Positive and Negative Syndrome Scale (PANSS). Individual-based growth mixture modeling combined with interplay matrix was used to identify the latent trajectory patterns in terms of both the negative and positive symptoms. Pearson correlation coefficients were calculated to examine the relationship between the changes of these two symptom domains within each combined trajectory pattern.ResultsWe identified four distinct negative symptom trajectories and three positive symptom trajectories. The trajectory matrix formed 11 combined trajectory patterns, which evidenced that negative and positive symptom trajectories moved generally in parallel. Correlation coefficients for changes in negative and positive symptom subscale scores were positive and statistically significant (P < 0.05). Overall, the combined trajectories indicated three major distinct patterns: 1) dramatic and sustained early improvement in both negative and positive symptoms (n = 70, 18%), 2) mild and sustained improvement in negative and positive symptoms (n = 237, 59%), and 3) no improvement in either negative or positive symptoms (n = 82, 21%).ConclusionsThis study of symptom trajectories over 1 year shows that changes in negative and positive symptoms were neither inversely nor independently related with each other. The positive association between these two symptom domains supports the notion that different symptom domains in schizophrenia may depend on each other through a unified upstream pathological disease process.

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Prevalence of item level negative symptoms in first episode psychosis diagnoses

Cited by 52 publications

References 34 publications

Investigation of white matter abnormalities in first episode psychosis patients with persistent negative symptoms

Investigation of white matter abnormalities in first episode psychosis patients with persistent negative symptoms

Metacognitive deficits predict future levels of negative symptoms in schizophrenia controlling for neurocognition, affect recognition, and self-expectation of goal attainment

The longitudinal interplay between negative and positive symptom trajectories in patients under antipsychotic treatment: a post hoc analysis of data from a randomized, 1-year pragmatic trial

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