Prevalence of Inducible Clindamycin Resistance in Staphylococcal Isolates at a Korean Tertiary Care Hospital

Abstract

Clindamycin resistance in Staphylococcus species can be either constitutive or inducible. Inducible resistance cannot be detected by the conventional antimicrobial susceptibility test. In this study, we determined the prevalence of inducible clindamycin resistance in staphylococcal isolates at a Korean tertiary care hospital. Between February and September 2004, 1,519 isolates of Staphylococcus aureus and 1,043 isolates of coagulase-negative staphylococci (CNS) were tested for inducible resistance by the D-zone test. Overall, 17% of MRSA, 84% of MSSA, 37% of MRCNS, and 70% of MSCNS were susceptible to clindamycin. Of the erythromycin non-susceptible, clindamycin-susceptible isolates, 32% of MRSA, 35% of MSSA, 90% of MRCNS, and 94% of MSCNS had inducible clindamycin resistance. Inducible clindamycin resistance in staphylococci was highly prevalent in Korea. This study indicates importance of the D-zone test in detecting inducible clindamycin resistance in staphylococci to aid in the optimal treatment of patients.

Novel Structure of Enterococcus faecium-Originated ermB -Positive Tn 1546 -Like Element in Staphylococcus aureus

“…The percentage of cMLS resistance (47%; 130/274) in the present study was similar to that found in an earlier study in southern Taiwan from 1995 to 2006 (52%; 77/149) (4) but much higher than in several other countries, such as Japan (10%; 48/478) (30), southeastern Turkey (8%; 1/13) (31), and Korea (20%; 40/205) (32). The iMLS phenotype was detected in 36% (98/274) of erythromycin-resistant MSSA isolates, which equals 68% (98/144) of erythromycin-resistant, clindamycin-susceptible strains, slightly lower than in a previous report from southern Taiwan (76%; 55/ 72) (4) or in Japan (93%; 397/428) (30) but higher than in Korea (35%; 58/165) (32) or in the United States (60%; 73/122) (33).…”

High rate of inducible clindamycin resistance in Staphylococcus aureus isolates – A multicenter study in Tokyo, Japan

“…The interpretation of this result is difficult; previous reports showed no apparent differences regarding the incidence of inducible resistance for erythromycin and clindamycin-susceptible MSSA and MRSA strains [12]. We postulate that this might be due to area-specific prevalence of each particular clone.…”

Prevalence of inducible clindamycin resistance in clinical isolates of coagulase negative staphylococci at a tertiary care hospital

“…This is where the D-test becomes significant. [15][16][17] Lim et al, [18] reported inducible resistance in 9.6% CoNS isolates by the disc diffusion test whereas Schmitz et al, [19] documented a fairly high …”