High rate of inducible clindamycin resistance in Staphylococcus aureus isolates – A multicenter study in Tokyo, Japan

Shoji, Kensuke; Shinjoh, Masayoshi; Horikoshi, Yuho; Tang, Julian; Watanabe, Y.; Sugita, Kayoko; Tame, T.; Iwata, Satoshi; Miyairi, Isao; Saitoh, Akihiko

doi:10.1016/j.jiac.2014.10.003

Cited by 11 publications

(8 citation statements)

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“…However, much higher rates (≥ 30%) was also reported by Moosavian et al and Saffar et al from Ahvaz and Tehran, respectively [ 14 , 35 ]. Moreover, the prevalence reported in our study is higher than those reported among staphylococci isolated from Brazil ( S. aureus , 0%) [ 12 ], and Mexico (CoNS, 8%) [ 27 ], whereas it is lower than those reported from Japan ( S. aureus , 91%) [ 28 ], Korea ( S. aureus , 34%; CoNS, 90%) [ 29 ], Poland (CoNS, 18.7%) [ 7 ], Nepal ( S. aureus , 11.5%) [ 30 ], and India ( S. aureus , 10.8%) [ 31 ].…”

Section: Main Textcontrasting

confidence: 69%

Phenotypic and genotypic characterization of macrolide, lincosamide and streptogramin B resistance among clinical isolates of staphylococci in southwest of Iran

et al. 2018

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ObjectiveThe present study aimed to determine the phenotypic and genotypic profile of macrolide, lincosamide and streptogramin B (MLSB) resistance in clinical isolates of staphylococci.ResultsThis cross-sectional study was conducted on 164 non-duplicated staphylococci isolates collected during August 2015 to February 2016 from two tertiary care hospitals in Shiraz, southwest of Iran. Of the 164 isolates, 86 erythromycin-resistant isolates consist of 35 Staphylococcus aureus and 51 coagulase negative staphylococci (CoNS) were included in the study. Of the 35 S. aureus, the prevalence of cMLS (constitutive), iMLS (inducible), and MS phenotypes were found 82.9%, 8.6% and 8.6%, respectively. Among 51 CoNS, the frequencies of cMLS, iMLS, and MS phenotypes were detected 66.7%, 11.8% and 21.6%, respectively. Among S. aureus isolates, the predominant genes were ermC in 82.9% isolates, followed by ermA in 57.1% and msrA in 28.6% of isolates. Among CoNS isolates, the most frequent genes were diagnosed ermC in 70.6% isolates followed by msrA in 68.6% and ermA in 11.8% of isolates. In conclusion, regarding the presence of MLSB resistance in our region, diagnosis of this resistance type on a routine basis in staphylococcal clinical isolates is of particular importance.

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Section: Main Textcontrasting

confidence: 69%

Phenotypic and genotypic characterization of macrolide, lincosamide and streptogramin B resistance among clinical isolates of staphylococci in southwest of Iran

et al. 2018

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“…Varying prevalence rates of iMLSB have been reported in different other studies; 2.1% from Brazil [25], 8% from Jamaica [26], 18.2% from Nepal [27], 25% from Cameroon [1], 28.6% from Iran [28], 20.7% [29] and 24.3% [30] from India. Higher iMLSB prevalence of 37.5% from India [31] and 91% from Japan [32] has also been reported. A comparatively low prevalence of inducible resistance in this study could be due to the geographical variations of circulatory clones.…”

Section: Discussionmentioning

confidence: 99%

Antibiotic susceptibility patterns of Staphylococcus aureus strains isolated at the Yaounde Central Hospital, Cameroon: a retro prospective study

Kengne¹,

Fotsing²,

Ndomgue³

et al. 2019

Pan Afr Med J

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Introduction Staphylococcus aureus is an important pathogen responsible for hospital and community acquired infection(s). Emerging resistance to methicillin in this organism has left physicians with few therapeutic alternatives to treat infections caused by it. This study was aimed at determining the antibiotic susceptibility patterns of Staphylococcus aureus strains isolated at the Yaounde Central Hospital, Cameroon. Methods from January 2014 to November 2016, a total of 250 non repeated strains were isolated from various clinical specimens. Isolates and antibiotic susceptibility profiles were identified through standard microbiological techniques. Results methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA) accounted respectively for 80% (201/205) and 20% (49/205) of the total strains isolated. MRSA strains displayed high resistance to cefoxitin (100%), cotrimoxazole (89%), vancomycin (79.7%), lincomycin (70.3%), tobramycin (72.5%), doxycycline (68.0%), kanamycin (69.7%) and erythromycin (55.7%). In contrast, a high susceptibility was observed with rifampicin (82.6%). KTG (42.3%) and constitutive MLSB (17.4%) were the most frequent phenotypes recorded. Conclusion our results show that the carriage of acquired MRSA infections predominates in this population. Despite the noticeable multiresistance of MRSA strains to antibiotics, rifampicin remains the drugs of choice for the therapy of acquired MRSA infections in this setting. In order to slow down antimicrobial resistance, surveillance studies for antimicrobial susceptibility remains essential to identify resistance and inform policy on resistance.

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“…Two studies from Turkey reported 89.1% and 77% susceptibility among their isolates (13, 30). In Japan, 70.5% of isolates were susceptible to both antibiotics (7). In terms of MLSB resistance, an extremely low prevalence of MLSB resistance (2.2%) was reported in the present study.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the increasing trend of resistance among S. aureus to macrolide-lincosamide-streptogramin B (MLSB) antibiotics in particular has been observed worldwide for the past few decades. For instance, persistently high prevalence rates of the inducible MLSB (iMLSB) phenotype were reported to be 94.0% in 2007 and 91.0% in 2015 in Japan (6, 7). This is not surprising because prevalence rates vary by geographical locations, by the type of strains being studied, and due to the local antibiotic policy (6, 8, 9).…”

Section: Introductionmentioning

confidence: 99%

A Low Prevalence of Inducible Macrolide, Lincosamide, and Streptogramin B Resistance Phenotype among Methicillin-Susceptible Staphylococcus aureus Isolated from Malaysian Patients and Healthy Individuals

Elkammoshi

Ghasemzadeh-Moghaddam

Nordin

et al. 2016

Jundishapur J Microbiol

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BackgroundAntibiotic resistance among Staphylococcus aureus is of great concern worldwide. This resistance is further complicated by the ability of S. aureus to confer cross-resistance to other antibiotics due to the presence of resistance genes, such as erythromycin resistance methylase (erm) genes, which render the bacterium resistant to macrolide-lincosamide-streptogramin B (MLSB) antibiotics. Resistance to these antibiotics can lead to therapeutic failure, resulting in significant morbidity and mortality in patients with S. aureus infections.ObjectivesThis study was performed to examine the distribution of MLSB-resistant strains of methicillin-susceptible S. aureus (MSSA), which were obtained from hospitalized patients and normal healthy individuals (carriers) using phenotypic methods, such as the double-disk diffusion (D-test) and the genotypic method by polymerase chain reaction (PCR).MethodsA total of 183 nonduplicative MSSA isolates obtained from hospitalized patients (133) and carriers (50) in our previous studies were randomly selected for the D-test. The guidelines of the Clinical and Laboratory Standards Institute (CLSI) were used for the interpretation of the results of this test. The detection of ermA, ermB, ermC and msrA genes by PCR was performed for isolates that had positive D-test results and that were resistant to erythromycin.ResultsOf the 183 MSSA isolates, 97.2% and 98.4% were highly susceptible to erythromycin and clindamycin, respectively. MSLB resistance was detected in four isolates (2.2%). Of the 133 MSSA isolated from hospitalized patients, only 3.0% (4/133) and 2.3% (3/133) exhibited resistance to erythromycin and clindamycin, respectively. With regard to the MLSB resistance phenotypes, only 1.6% and 0.6% exhibited inducible MLSB (iMLSB) and MS phenotypes, respectively. The ermC gene was detected in all three iMLSB phenotypes, and the msrA gene was detected in the MS phenotype. Surprisingly, all MSSA isolates (100%) from carriers exhibited extremely high susceptibility to both antibiotics.ConclusionsThe prevalence rates of iMLSB MSSA isolates vary according to geographical locations and the local antibiotic policy. The low prevalence rate of iMLSB MSSA isolates could probably be related to the judicious use of antibiotics for treating S. aureus infections in our studied population. Nonetheless, continuous antibiotic surveillance is still necessary to control any emergence of resistance isolates so that targeted therapy and effective control can be implemented accordingly.

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High rate of inducible clindamycin resistance in Staphylococcus aureus isolates – A multicenter study in Tokyo, Japan

Cited by 11 publications

References 19 publications

Phenotypic and genotypic characterization of macrolide, lincosamide and streptogramin B resistance among clinical isolates of staphylococci in southwest of Iran

Phenotypic and genotypic characterization of macrolide, lincosamide and streptogramin B resistance among clinical isolates of staphylococci in southwest of Iran

Antibiotic susceptibility patterns of Staphylococcus aureus strains isolated at the Yaounde Central Hospital, Cameroon: a retro prospective study

A Low Prevalence of Inducible Macrolide, Lincosamide, and Streptogramin B Resistance Phenotype among Methicillin-Susceptible Staphylococcus aureus Isolated from Malaysian Patients and Healthy Individuals

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