Prevalence of inducible clindamycin resistance in Staphylococcus aureus isolated from clinical samples

Lall, Mahima; Sahni, A.K.

doi:10.1016/j.mjafi.2013.01.004

Cited by 52 publications

(62 citation statements)

References 16 publications

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“…This study shows a significantly higher prevalence of MLSBi as well as MLSBc in MRSA strains than MSSA which is consistent with other reports [11][12][13]. Molecular studies have shown that some SCCmec elements carry transposon Tn554 which contains the gene ermA mediating MLS resistance [19].…”

Section: Discussionsupporting

confidence: 92%

“…Higher MLSBi prevalence of 45% from Germany [15] and 62% from US [16] has also been reported. Constitutive resistance (7.9%) was lower than that reported elsewhere [11][12][13]. A comparatively low prevalence of inducible and constitutive resistance in this study indicates a greater utility of clindamycin in our setting.…”

Section: Discussioncontrasting

confidence: 66%

“…Varying prevalence rates of MLSBi have been reported in different other studies; 18.2%from Nepal [11], 19.8%from Turkey [12], 20.3% [13] and 8.4% [14] from India. Higher MLSBi prevalence of 45% from Germany [15] and 62% from US [16] has also been reported.…”

Section: Discussionmentioning

confidence: 76%

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Inducible and constitutive clindamycin resistance in Staphylococcus aureus: an experience from Western Nepal

Sah¹,

Khanal²,

Lamichhane³

et al. 2015

Int Jour of Biomed Res

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Objective: This study aimed to determine prevalence of inducible and constitutive clindamycin resistance among clinical S. aureus isolates and also study their association with methicillin resistance. Methods: A cross-sectional study including 140 non-duplicate isolates of S. aureus was done. Isolates were identified by standard microbiological methods and methicillin resistance was detected by cefoxitin disc diffusion method. Inducible clindamycin resistance was detected by D-test. Results: Prevalence of inducible and constitutive clindamycin resistance was 12.1% and 7.9% respectively. Constitutive and inducible resistance was associated with MRSA. An unusual phenotype, erythromycin sensitive and clindamycin resistance, was detected in 2 MRSA isolates. Conclusions: Inducible and constitutive clindamycin resistance is comparatively low in our setting. Constitutive and inducible resistance was higher among MRSA than MSSA. However the trends in resistance vary in different places. D-test reporting should be done routinely which will allow clinicians to opt for clindamycin judiciously and avoid potential treatment failure.

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Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 66%

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Inducible and constitutive clindamycin resistance in Staphylococcus aureus: an experience from Western Nepal

Sah¹,

Khanal²,

Lamichhane³

et al. 2015

Int Jour of Biomed Res

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“…It was observed that percentage of inducible clindamycin resistance was higher among MRSA (22.58%) compared to MSSA (8.9%).This finding conforms to many published studies such as Gade et al, (2013), Majhi et al, (2016) and Lall et al, (2014). On the contrary, Sasirekha et al, (2014) and Bottega et al, (2014) had shown a higher percentage of inducible resistance in MSSA compared to MRSA.…”

Section: Resultssupporting

confidence: 86%

Inducible Clindamycin Resistance among Clinical Isolates of Staphylococcus aureus in a Tertiary Care Hospital, Nanded, Maharashtra, India

More¹,

Rathod²,

Khan³

2017

Int.J.Curr.Microbiol.App.Sci

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“…14,15 Several studies done across the country have reported that constitutive and inducible MLSB strains are seen more in MRSA than in MSSA strains. [16][17][18][19][20][21] Since MLSBi strains cannot be detected by automated susceptibility testing or E-test, performing a simple, inexpensive, easy to perform and reproducible test such as D-test can be included as a part of routine antibiotic susceptibility testing. 22 Pus/wound sample accounted for the majority (n=58) from which S. aureus has been isolated and a high number of them showed MLSBc (n=17) and MLSBi (n=15) clindamycin resistance.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of constitutive and inducible clindamycin resistance among clinical isolates of Staphylococcus aureus in a tertiary care institute in North India

Shetty

Afroz

2017

Int J Res Med Sci

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Background: Clindamycin is an important drug used in the treatment of Methicillin Sensitive Staphylococcus aureus (MSSA) as well as in Methicillin-resistant Staphylococcus aureus (MRSA) infections. This drug is widely used in the treatment of skin and soft tissue infections caused by them. Therapeutic failure caused by macrolide-lincosamine-streptogramin B constitutive and inducible clindamycin resistance (MLSBc and MLSBi) is being more commonly reported.Methods: The present study was conducted over a period of six months from October 2016 to March 2017 to know the incidence of MLSBc and MLSBi in Staphylococcus aureus (S. aureus) isolates obtained in our hospital by D-test as per CLSI guidelines. A total of 130 isolates of S.aureus were obtained from different clinical specimens which included pus/ wound swab (n=266), urine (n=577), sputum (n=225), blood (n=221), throat swab (n=71), ear/eye discharge (n=21), high vaginal swab (n=20) and body fluids (n=50). All the isolates were subjected to antibiotic sensitivity testing by Kirby Bauer’s disc diffusion method. Amoxyclav, Erythromycin, Clindamycin, Co-trimoxazole, Tetracycline, Ofloxacin, Gentamicin, Linezolid and Vancomycin were the antibiotics used.Results: Out of 130 (8.9%) isolates of S. aureus obtained from 1451 clinical samples, 82 (63.1%) were found to be MSSA and 48 (36.9%) were MRSA. Among S. aureus, 43 (33.1%) isolates showed MLSBc resistance, 22 (16.9%) isolates showed MLSBi resistance and 20 (15.4%) isolates showed MS phenotype. The remaining 45 (34.6%) isolates remained sensitive to Erythromycin. Among MSSA, MLSBc were observed in 18 (22%) isolates and MLSBi in 9 (11%) while in MRSA, MLSBc were observed in 25 (52.1%) isolates and MLSBi in 13 (27.1%) isolates. Almost all clinical isolates showed 100% sensitivity to Vancomycin and Linezolid in routine antibiotic susceptibility testing. Both MLSBc and MLSBi resistance was significantly higher (p<0.05) in MRSA than in MSSA.Conclusions: The study emphasizes the importance of conducting D test along with routine antibiotic susceptibility testing for better utilization of clindamycin in S. aureus infections.

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Prevalence of inducible clindamycin resistance in Staphylococcus aureus isolated from clinical samples

Cited by 52 publications

References 16 publications

Inducible and constitutive clindamycin resistance in Staphylococcus aureus: an experience from Western Nepal

Inducible and constitutive clindamycin resistance in Staphylococcus aureus: an experience from Western Nepal

Inducible Clindamycin Resistance among Clinical Isolates of Staphylococcus aureus in a Tertiary Care Hospital, Nanded, Maharashtra, India

Prevalence of constitutive and inducible clindamycin resistance among clinical isolates of Staphylococcus aureus in a tertiary care institute in North India

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