PREVALENCE OF <i>HELICOBACTER PYLORI</i> INFECTION IN 160 PATIENTS WITH BARRETT’S OESOPHAGUS OR BARRETT’S ADENOCARCINOMA

Lord, Reginald V.; Frommer, D.; Inder, S.J; Tran, Dinh; Ward, Robyn L.

doi:10.1046/j.1440-1622.2000.01737.x

Cited by 48 publications

(31 citation statements)

References 52 publications

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“…The tendency of higher percentage of male gender and esophagitis, and lower prevalence of H. pylori infection among the patients with BE CK7/20 staining pattern, is also very interesting, since the same is known to be true for BE (47,48). Although not statistically signi cant in this small sample, these results could further support the CK7/20 staining pattern being a feasible marker for BE.…”

Section: Discussionmentioning

confidence: 54%

Immunohistochemical Markers for Barrett’s Esophagus and Associations to Esophageal Z-Line Appearance

Wallner¹,

Sylvan²,

Janunger³

et al. 2001

Scandinavian Journal of Gastroenterology

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Section: Discussionmentioning

confidence: 54%

Immunohistochemical Markers for Barrett’s Esophagus and Associations to Esophageal Z-Line Appearance

Wallner¹,

Sylvan²,

Janunger³

et al. 2001

Scandinavian Journal of Gastroenterology

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“…17 This result is consistent with several other previous studies that suggested a protective effect of H. pylori infection against BE. [18][19][20] There were seven patients in whom BE was grossly suspected, but who were found to have columnar epithelium without any goblet cells, and who were excluded from the study. Of these seven patients, five patients had hiatal hernia (71.4%).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Barrett's esophagus in an urban Korean population: a multicenter study

Lee

Park

Jung³

et al. 2003

Journal of Gastroenterology

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“…58 -60 An inverse association between H. pylori infection and the presence of Barrett esophagus has also been found. [61][62][63][64] It is thus possible that certain types of H. pylori infection may promote noncardia gastric adenocarcinoma development but may protect against the development of Barrett esophagus and the Barrett-associated adenocarcinomas of the esophagus and cardia.…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance of p53 Mutations in Adenocarcinoma of the Esophagus and Cardia

Ireland

Shibata²,

Chandrasoma³

et al. 2000

Annals of Surgery

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ObjectiveTo compare the frequency and spectrum of p53 gene mutations in adenocarcinomas of the esophagus and cardia and to compare clinical and pathologic features in patients with p53 mutant and nonmutant cancers. Summary Background DataThe p53 gene is commonly mutated in human cancers, and a p53 mutation is reported to be present in more than 50% of esophageal adenocarcinomas. Although many studies have investigated the frequency of p53 protein overexpression in adenocarcinomas of the esophagus or esophagogastric junction, few studies have assessed the frequency and clinical significance of p53 mutations in these tumors. In particular, the prognostic importance of p53 mutation is uncertain. Adenocarcinomas of the esophagus and cardia share many epidemiologic and pathologic features, but it is controversial whether they represent the same tumor. A comparison of the frequency and spectrum of mutations in adenocarcinomas of the esophagus and cardia would test whether these tumors are also similar at the molecular level. MethodsDNA was isolated from microdissected paraffin-embedded tumor tissues of patients who underwent esophagogastrectomy for adenocarcinoma of the esophagus (n ϭ 19), cardia (esophagogastric junction, n ϭ 12), or subcardia (n ϭ 6). Exons 5 to 8 of the p53 gene were analyzed for the presence of mutations using the polymerase chain reaction with singlestrand conformation polymorphism and DNA sequencing of bands showing abnormal mobility. The presence of mutation was confirmed by selective hybridization of a mutant-specific oligonucleotide to DNA isolated from the tumor. Resultsp53 mutations were identified in 18 of 37 (48.6%) tumors. Patients with p53 mutant tumors were significantly younger and had a significantly poorer prognosis. There was a similar prevalence of p53 mutations in adenocarcinomas of the esophagus (53%) and cardia (58%). In contrast, mutations were relatively uncommon in subcardia adenocarcinomas (one mutant tumor [17%]). The types of mutations found in the esophageal and the cardia cancers were also similar.

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PREVALENCE OF HELICOBACTER PYLORI INFECTION IN 160 PATIENTS WITH BARRETT’S OESOPHAGUS OR BARRETT’S ADENOCARCINOMA

Abstract: Oesophageal H. pylori infection is uncommon in patients with Barrett's IM, dysplasia, or adenocarcinoma, and may be restricted to non-intestinalized columnar epithelium. Gastric H. pylori infection may have a protective effect for the development of Barrett's oesophagus.

Cited by 48 publications

References 52 publications

Immunohistochemical Markers for Barrett’s Esophagus and Associations to Esophageal Z-Line Appearance

Immunohistochemical Markers for Barrett’s Esophagus and Associations to Esophageal Z-Line Appearance

Prevalence of Barrett's esophagus in an urban Korean population: a multicenter study

Clinical Significance of p53 Mutations in Adenocarcinoma of the Esophagus and Cardia

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