Prevalence of Barrett's esophagus in an urban Korean population: a multicenter study

Lee, Jung Il; Park, Hyojin; Jung, Hwoon Yong; Rhee, Poong–Lyul; Song, Chi; Choi, Myung-Gyu

doi:10.1007/s005350300002

Cited by 35 publications

(27 citation statements)

References 12 publications

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“…One study found that the prevalence of endoscopic CLE in patients with clinical indications was 7.5% [21]. The first multicenter prospective study for LSBE was conducted on 1,553 patients at five referral hospitals in Seoul, and the prevalence of BE was 0.3% [22]. After 2 years, the prevalence of SSBE was assessed prospectively in four referral hospitals of Seoul and the metropolitan areas on 992 patients; CLE was found in 108 patients (10.9%), the overall prevalence of SIM was 3.6%, and only three patients had LSBE [23].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Barrett’s Esophagus Remains Low in the Korean Population: Nationwide Cross-Sectional Prospective Multicenter Study

et al. 2009

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Purpose In contrast to the Western population, the prevalence of Barrett's esophagus (BE) is rare in the Korean population. However, the recent increase in prevalence of gastroesophageal reflux disease (GERD) may affect the prevalence of BE. The aim of this study was to survey the prevalence of BE and evaluate its risk factors. Methods Patients between 18 and 75 years of age who visited 11 Korean tertiary referral centers between April and July 2006 for routine upper endoscopic examination were surveyed using a symptom questionnaire. Biopsies were performed on the columnar lined epithelium (CLE) of the distal esophagus, and diagnosis was confirmed with detection of specialized intestinal metaplasia. Results The study comprised 2,048 patients (mean age 51.4 years, 965 males). The frequency of heartburn or acid regurgitation was 8.7% and 13.1%, respectively. Reflux esophagitis was diagnosed in 10.1% of patients (207 patients); however, most patients had mild reflux. CLE was found in 82 patients; however, only one patient had longsegment CLE. The prevalence of BE was 1% (21 patients). The risk factors for BE were age (P = 0.006), presence of heartburn [odds ratio (OR) 4.33, 95% confidence interval (CI) 1.66-11.34, P = 0.007], acid regurgitation (OR 3.37, 95% CI 1.35-8.42, P = 0.01), sliding hernia (OR 6.21, 95% CI 1.78-21.72, P = 0.001), and reflux esophagitis Sci (2010) 55:1932-1939 DOI 10.1007 (OR 10.28, 95% CI 4.31-24.50, P \ 0.0001) on univariate analysis. On multivariate analysis, presence of typical reflux symptoms (P = 0.02) and reflux esophagitis (P \ 0.001) were significant. Conclusions Prevalence of Barrett's esophagus remains low in Koreans; however, risk of developing BE has increased in patients with GERD symptoms and reflux esophagitis.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Barrett’s Esophagus Remains Low in the Korean Population: Nationwide Cross-Sectional Prospective Multicenter Study

et al. 2009

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“…In Asian countries, long-segment BE is much less prevalent compared to Western countries [11,35]; thus, it has been difficult to understand its characteristics in this geographical area. In Japan, long-segment BE defined by a circumferential length of 3 cm or more is a considerably rare condition, with a reported prevalence as low as 0.2-0.6% [36,37].…”

Section: Discussionmentioning

confidence: 99%

“…In addition to the established risk factors for BE, such as GE reflux diseases (GERD), hiatal hernia, being an elderly male, and Caucasian race [7], obesity has been frequently identified as a predisposing factor for BE [7,8,9]. However, almost all of the studies on risk factors for BE thus far have originated from Western countries, largely because the incidence of BE, and in particular long-segment BE, is much lower in Asian countries compared to Western countries [10,11]. Since some studies have suggested that the risk factors differ among different ethnic groups [12,13], the risk factors for Asian subjects with BE remain to be clarified.…”

Section: Introductionmentioning

confidence: 99%

Association between the Body Mass Index and the Risk of Barrett's Esophagus in Japan

Shinkai

Iijima²,

Koike³

et al. 2014

Digestion

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Background: We investigated the association between long-segment Barrett's esophagus and obesity in the Japanese population in a multicenter case-control trial. Methods: One hundred thirteen patients with endoscopically detected Barrett's esophagus with a length of more than 2 cm and the same number of sex- and age-matched controls were prospectively enrolled. Barrett's esophagus was diagnosed based on the Prague C and M criteria. The body mass index (BMI) of the subjects was categorized into the following groups: normal, BMI <22.9; overweight, BMI 23.0-24.9, and obese, BMI >25.0. To determine the association between BMI and the risk of Barrett's esophagus, multivariate logistic regression analyses were performed. Results: The basically adjusted regression model adjusted for smoking and alcohol consumption revealed that overweight and obesity were significantly associated with an elevated risk of Barrett's esophagus (OR 2.4, 95% CI 1.2-4.7, and OR 2.5, 95% CI 1.3-4.6, respectively). The intensity of the association was not attenuated even after adjustment for gastroesophageal reflux disease-related parameters. Conclusions: An increased BMI was associated with an increased risk for Barrett's esophagus through a gastroesophageal reflux-independent mechanism in the Japanese population. Further, unlike in Caucasian populations, being even slightly overweight with a BMI of 23.0-24.9 was an independent risk factor in the Japanese population.

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“…17 Most Korean patients, however, have been found to have short segment Barrett's epithelium, with long segment Barrett's esophagus being quite rare. 18,19 If a tumor is not detected early, the chance of finding the specialized intestinal metaplasia (SIM) was very low. This may explain why most Barrett's cancers in Korean patients were small sized (less than 20 mm sized) and shallow depth of invasion.…”

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Clinicopathologic Characteristics of Barrett's Cancer in Korea

Chung

Lee²,

Jung³

et al. 2008

Gut Liver

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Prevalence of Barrett's esophagus in an urban Korean population: a multicenter study

Abstract: The period prevalence of BE among the patients of five referral hospitals was 3.2 per 1000, and it seems that the prevalence of BE in Korean urban area is lower than that in Western countries.

Cited by 35 publications

References 12 publications

Prevalence of Barrett’s Esophagus Remains Low in the Korean Population: Nationwide Cross-Sectional Prospective Multicenter Study

Prevalence of Barrett’s Esophagus Remains Low in the Korean Population: Nationwide Cross-Sectional Prospective Multicenter Study

Association between the Body Mass Index and the Risk of Barrett's Esophagus in Japan

Clinicopathologic Characteristics of Barrett's Cancer in Korea

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