Clinicopathologic Characteristics of Barrett's Cancer in Korea

Chung, Jun‐Won; Lee, Gin Hyug; Jung, Hwoon‐Yong; Choi, Kee Don; Song, Ho June; Choi, Kyeong‐Hee; Oh, Hyung Chul; Jung, Kee Wook; Choe, Jun-Ho; Kim, Jeong Won; Yu, Eunsil; Kim, Jin-Ho

doi:10.5009/gnl.2008.2.3.193

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…In this study, Barrett’s neoplasia was predominant in men, and the incidence of hiatal hernia, reflux esophagitis, and atrophic gastritis (open type) in patients with Barrett’s neoplasia was 67%, 17%, and 11%, respectively, which is consistent with the results of a previous study in Japan [ 25 ]. In most cases, Barrett’s neoplasia was located in the right hemisphere, which is consistent with the data of previous studies in Western countries and Asia [ 25 26 27 ]. Regarding the macroscopic shape of Barrett’s neoplasia, elevated lesions are common in SSBE and flat/depressed lesions in LSBE [ 25 28 ].…”

Section: Discussionsupporting

confidence: 91%

“…In our study, local recurrence occurred in 2 cases with incomplete resection. In LSBE, which is more frequently observed in Western countries, metachronous neoplasia may develop from residual BE; however, in Asian countries, including Korea and Japan, most BE cases are SSBE [ 27 40 ]. A recent study in Japan reported a 5-year cumulative incidence of metachronous cancer of 1.1% [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

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Endoscopic Submucosal Dissection for Superficial Barrett’s Neoplasia in Korea: a Single-Center Experience

et al. 2021

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Purpose While the incidence of Barrett’s neoplasia has been increasing in Western countries, the disease remains rare in Asian countries. Therefore, very few studies have investigated the endoscopic treatment for Barrett’s neoplasia in Korea. Endoscopic submucosal dissection (ESD) enables en bloc and complete resection of gastrointestinal neoplastic lesions. This study aimed to evaluate the therapeutic outcomes of ESD for Barrett’s neoplasia in a single center in Korea and to examine the predictive factors for incomplete resection. Materials and Methods We conducted a retrospective observational study of 18 patients who underwent ESD for superficial Barrett’s neoplasia (dysplasia and early cancer) between January 2010 and December 2019 at Pusan National University Hospital. The therapeutic outcomes of ESD and procedure-related complications were analyzed. Results En bloc resection, complete resection, and curative resection were performed in 94%, 72%, and 61% of patients, respectively. Histopathology (submucosal or deeper invasion of the tumor) was a significant predictive factor for incomplete resection (P=0.047). Procedure-related bleeding and stenosis were not observed, whereas perforation occurred in one case. During the median follow-up period of 12 months (range, 6–74 months), local recurrence occurred in 2 patients with incomplete resection, one patient underwent repeat ESD, and the other patient received concurrent chemoradiotherapy. The 3-year overall and disease-specific survival rates were 73% and 93%, respectively. Conclusions ESD seems to be an effective and safe treatment for superficial Barrett’s neoplasia in Korea. Nevertheless, the suitability of ESD for Barrett’s cancer cases should be determined considering the high risk of deep submucosal invasion.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Endoscopic Submucosal Dissection for Superficial Barrett’s Neoplasia in Korea: a Single-Center Experience

et al. 2021

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“…Finally, although we tried to include only true gastric cardia tumors using a strict definition, there is still a possibility that some Barrett's tumors might have been included because almost all Barrett's cancers occur in the ultrashort-segment or short-segment Barrett's epithelium in Korean patients. 29 …”

Section: Discussionmentioning

confidence: 99%

Factors Associated With Outcomes in Endoscopic Submucosal Dissection of Gastric Cardia Tumors

et al. 2015

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Tumors of the gastric cardia are among the most technically difficult lesions to remove by endoscopic submucosal dissection (ESD). This study aimed to evaluate the therapeutic outcomes of ESD in gastric cardia tumors according to clinicopathologic characteristics, and to assess the predictive factors for incomplete resection.We conducted a retrospective observational study of 82 patients with adenomas and early cancers of the gastric cardia who underwent ESD between January 2006 and December 2013 at the Pusan National University Hospital. Therapeutic outcomes of ESD and procedure-related complications were analyzed.En bloc resection, complete resection, and curative resection rates were 87%, 79%, and 66%, respectively. Deep submucosal invasion was the most common cause of noncurative resection in the cases in which complete resection was achieved. On multivariate analyses, hemispheric distribution (anterior hemisphere; odds ratio [OR] 4.808) and depth of tumor invasion (submucosal cancer; OR 22.056) were independent factors associated with incomplete resection. The rates of procedure-related bleeding, perforation, and stenosis were 6%, 1%, and 0%, respectively; none of the complications required surgical intervention.In conclusion, ESD is a safe, effective, and feasible treatment for gastric cardia tumors. However, the complete resection rate decreases for tumors that are located in the anterior hemisphere or have deep submucosal invasion.

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Physicians' Opinion on Asymptomatic Reflux Esophagitis and Short Segment Barrett's Esophagus

Kim

Lee

2014

Korean J Helicobacter Up Gastrointest Res

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Clinicopathologic Characteristics of Barrett's Cancer in Korea

Cited by 3 publications

References 18 publications

Endoscopic Submucosal Dissection for Superficial Barrett’s Neoplasia in Korea: a Single-Center Experience

Endoscopic Submucosal Dissection for Superficial Barrett’s Neoplasia in Korea: a Single-Center Experience

Factors Associated With Outcomes in Endoscopic Submucosal Dissection of Gastric Cardia Tumors

Physicians' Opinion on Asymptomatic Reflux Esophagitis and Short Segment Barrett's Esophagus

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