“…22 As a result, a problem with the thyroid must be one of the conditions ruled out before a woman's PCOS diagnosis can be made, even though there is active controversy regarding SCH's influence on PCOS. 23 However, there is evidence from both research and pathophysiology to suggest that SCH may affect PCOS-related symptoms such as metabolic and ovulation problems. 10 In contrast, when someone has primary hypothyroidism, overall thyrotropin-releasing hormone (TRH) levels rise, which causes their TSH and prolactin levels to increase.…”
Polycystic ovary syndrome (PCOS), is a very common endocrine and metabolic disorder in premenopausal women that affects 1 in 10 women of childbearing age. According to recent studies, the prevalence of PCOS was found around 53%. Many studies showed that subclinical hypothyroidism (SCH) and PCOS share symptoms which can influence PCOS symptoms like infertility and hormonal changes. This systematic review aimed to evaluate the impact of SCH on infertility and other metabolic parameters in women with polycystic ovarian syndrome in South Asia. For this review work, after a literature search through PubMed, Cochrane, and Google Scholar, 5 relevant papers were identified for this systematic review. The publication time was limited to the most recent 10 years, from 2011 to 2022. This review considered quantitative research on PCOS and SCH and used evidence-based data to support the findings. Among the mentioned 5 studies, 3 were cross-sectional and 2 were case-control. The studies were conducted on 2 groups: the SCH-PCOS intervention group and the PCOS control group. For the quality assessment, Cochrane's software, review manager (RevMan) was used to eliminate duplicate studies and reduce bias. The systematic review was conducted on 1468 female patients and measured anthropometric parameters in both groups. Total cholesterol, body mass index (BMI), TSH, free testosterone levels, insulin resistance and menstrual irregularities were all higher in the SCH-PCOS group compared to the PCOS group, along with a p<0.001 for each of the parameters. Usually, SCH and PCOS share symptoms. In cholesterol, BMI, TSH, free testosterone levels, insulin resistance and menstrual irregularities there are significant correlations between SCH and PCOS. So, there are some potential impacts of SCH on infertility and other metabolic parameters in women with polycystic ovarian syndrome in South Asia.
“…22 As a result, a problem with the thyroid must be one of the conditions ruled out before a woman's PCOS diagnosis can be made, even though there is active controversy regarding SCH's influence on PCOS. 23 However, there is evidence from both research and pathophysiology to suggest that SCH may affect PCOS-related symptoms such as metabolic and ovulation problems. 10 In contrast, when someone has primary hypothyroidism, overall thyrotropin-releasing hormone (TRH) levels rise, which causes their TSH and prolactin levels to increase.…”
Polycystic ovary syndrome (PCOS), is a very common endocrine and metabolic disorder in premenopausal women that affects 1 in 10 women of childbearing age. According to recent studies, the prevalence of PCOS was found around 53%. Many studies showed that subclinical hypothyroidism (SCH) and PCOS share symptoms which can influence PCOS symptoms like infertility and hormonal changes. This systematic review aimed to evaluate the impact of SCH on infertility and other metabolic parameters in women with polycystic ovarian syndrome in South Asia. For this review work, after a literature search through PubMed, Cochrane, and Google Scholar, 5 relevant papers were identified for this systematic review. The publication time was limited to the most recent 10 years, from 2011 to 2022. This review considered quantitative research on PCOS and SCH and used evidence-based data to support the findings. Among the mentioned 5 studies, 3 were cross-sectional and 2 were case-control. The studies were conducted on 2 groups: the SCH-PCOS intervention group and the PCOS control group. For the quality assessment, Cochrane's software, review manager (RevMan) was used to eliminate duplicate studies and reduce bias. The systematic review was conducted on 1468 female patients and measured anthropometric parameters in both groups. Total cholesterol, body mass index (BMI), TSH, free testosterone levels, insulin resistance and menstrual irregularities were all higher in the SCH-PCOS group compared to the PCOS group, along with a p<0.001 for each of the parameters. Usually, SCH and PCOS share symptoms. In cholesterol, BMI, TSH, free testosterone levels, insulin resistance and menstrual irregularities there are significant correlations between SCH and PCOS. So, there are some potential impacts of SCH on infertility and other metabolic parameters in women with polycystic ovarian syndrome in South Asia.
There is increasing proof that polycystic ovary syndrome (PCOS) is associated with the increased frequency of thyroid disturbances. Chamomile (Matricaria chamomilla L.) herb and metformin showed therapeutic efficacy against polycystic ovary syndrome (PCOS). This study aimed to investigate the possible therapeutic effect of both chamomile flower extract and metformin against thyroid damage associated with PCOS in rats. The PCOS model was developed in rats by injecting estradiol valerate, and it was confirmed to be associated with thyroid hypofunction biochemically and pathologically. Treatment of PCOS rats with both chamomile extract and metformin resulted in an improvement in serum level of thyroid hormones (TSH, p < 0.01; T3 and T4, p < 0.05) and the disappearance of most thyroid gland pathological changes demonstrated by light and electron microscopes. They also reduced the level of serum estrogen (p < 0.01). Both chamomile extract and metformin decreased MDA (p < 0.05) and increased GPx and CAT (p < 0.01). Only chamomile extract increased GSH (p < 0.01). Both treatments reduced the apoptotic death of thyroid cells as noted by the reduction of caspase-3 immunoexpression (p < 0.01). In conclusion, both Matricaria chamomilla extract and metformin ameliorated hypothyroidism associated with PCOS through an antioxidant and antiapoptotic mechanism.
Hypothyroidism during pregnancy is the most commonly found endocrine disorder. Its effect during pregnancy has widely been studied among
women to understand the pathophysiology, outcomes, and prevalence. We collected data from several studies of last One Decade from separately
studied population among all across the country regarding hypothyroid abundance. We compared more than 61 online available studies for the
validation of data prevalence and to understand the status of associated risks to the mother and child in current scenario. Various risks like
preeclampsia, preterm labor, anemia, IUGR, spontaneous birth, still birth, low birth weight infants, have been claimed associated in more than
thirty ve studies from the nation, few of them also lighted shed on developmental disorders in neonates born under such conditions. This study
conserves biggest data of 43,282 women studied for such condition. Here we found 6,952 women effected by hypothyroid, which makes an average
prevalence of 14.2% and it ranges from 2.5% (lowest) - 33.82% (highest) in different places in pregnant women. This gure is higher than the
reported global prevalence. These studies also found increased number of bad obstetric outcome for antenatal and postnatal risks in mothers. To
prevent consequences universal screening should be acquired.
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