Hypothyroidism during pregnancy is the most commonly found endocrine disorder. Its effect during pregnancy has widely been studied among women to understand the pathophysiology, outcomes, and prevalence. We collected data from several studies of last One Decade from separately studied population among all across the country regarding hypothyroid abundance. We compared more than 61 online available studies for the validation of data prevalence and to understand the status of associated risks to the mother and child in current scenario. Various risks like preeclampsia, preterm labor, anemia, IUGR, spontaneous birth, still birth, low birth weight infants, have been claimed associated in more than thirty ve studies from the nation, few of them also lighted shed on developmental disorders in neonates born under such conditions. This study conserves biggest data of 43,282 women studied for such condition. Here we found 6,952 women effected by hypothyroid, which makes an average prevalence of 14.2% and it ranges from 2.5% (lowest) - 33.82% (highest) in different places in pregnant women. This gure is higher than the reported global prevalence. These studies also found increased number of bad obstetric outcome for antenatal and postnatal risks in mothers. To prevent consequences universal screening should be acquired.
Context: Aneuploidy screening is done in the early second trimester of pregnancy among all pregnant women as compulsory, with a special focus on those who had abnormal ultrasound parameters, higher dual marker risk, or other comorbidities. Recently, all individual quad markers of conventional trisomy screening have been suggested as useful in predicting adverse pregnancy outcomes (APO) such as preeclampsia, preterm labor, small for gestational age, and placental abruptions. However, similar studies on Indian pregnant women are limited. Hence, this study was intended to find the relation of quadruple markers with any other APO than aneuploidy. Materials and Methods: A retrospective study was conducted in a Tertiary Care multi-specialty hospital in North India. Data from 252 pregnant women’s quadruple test was analyzed. The association of abnormal value of quadruple markers (human chorionic gonadotropin [HCG]/alpha-fetoprotein/uE3/Inhibin A) with adverse outcomes was evaluated. Multiple logistic regression analysis and classification and regression tree were used to predict the significant risk factor in high-risk pregnancies. Results: In the study, a total ( n = 252) of pregnant women, 190 were screened as high-risk pregnancies, whereas the remaining 62 were reported as low-risk using trisomy screening in the quadruple test. Baby birth weight was observed to be significantly associated with Inhibin-A, and HCG ( P < 0.001), whereas Corrected (Corr)-multiple of median (MoM)-HCG (>1.415) and Inhibin-A Corr-MoM (>364.175) were the suitable predictor for the LBW. Both parameters were significantly higher in the high-risk group as compared to the low-risk group (each P < 0.05). Conclusion: Abnormal deviation of biochemical markers from aneuploidy screening assessment could help predict other perinatal adverse outcomes such as low birth weight babies.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.