Prevalence of hyperuricemia and its association with antihypertensive treatment in hypertensive patients in Taiwan

Lin, Chiu‐Chu; Lee, Wen-Ling; Hung, Yi‐Jen; Lee, Du-Yi; Chen, Kuei-Feng; Chi, Wen-Che; Chang, Shin-Chieh

doi:10.1016/j.ijcard.2010.10.033

Cited by 30 publications

(32 citation statements)

References 21 publications

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“…11,[21][22][23] The mechanism underlying the slightly lower prevalence of hyperuricemia in males aged ≥85 than in those aged 75-84 years remains unclear; nevertheless, in females, the increase in hyperuricemia prevalence with increasing age may be explained by postmenopausal changes in the endocrine system and estrogen levels. 22 Consistent with other studies, 21,22,25 we observed a positive association between hyperuricemia and metabolic disorders in our Chinese population. Epidemiological studies have also reported an association between hyperuricemia and metabolic disorders such as metabolic syndrome, hyperlipidemia, obesity, and type 2 diabetes.…”

Section: 11-14supporting

confidence: 92%

“…The prevalence of hyperuricemia among different screened populations seems to vary between countries. [16][17][18][19][20][21][22][23][24][25] This disparity is likely due to differences among various populations with regard to participant characteristics (e.g., age, socioeconomic status, and abnormal associated factors), study period, and different diagnostic definitions for elevated serum uric acid levels. The prevalence of hyperuricemia in our study population (30.4%) was higher than that reported in previous population-based studies conducted in general Chinese populations.…”

Section: 11-14mentioning

confidence: 99%

“…The prevalence of hyperuricemia in our study population (30.4%) was higher than that reported in previous population-based studies conducted in general Chinese populations. 11,16,[20][21][22]25 The agricultural and fishing population endures strenuous working conditions, job stress, and reversed working and resting times compared to those of the general population. 5 Irregular lifestyles and carelessness regarding personal health are also major problems in this population.…”

Section: 11-14mentioning

confidence: 99%

“…Epidemiological studies have also reported an association between hyperuricemia and metabolic disorders such as metabolic syndrome, hyperlipidemia, obesity, and type 2 diabetes. 11,22,25 Metabolic syndrome is a cluster of three diseases-hypertension, hyperglycemia, and gout, 11 Although metabolic syndrome is clearly associated with obesity, insulin resistance, and abnormal blood lipids, which lead to the three diseases, the etiological mechanisms of this 26 Previous studies have indicated that serum uric acid level can be used as a crucial predictor of metabolic syndrome and that the number of metabolic syndrome components increases the prevalence and OR for significantly increased uric acid activity. 11,27,28 Among patients with chronic hepatitis, fructose load may cause a substantial increase in serum uric acid levels.…”

Section: 11-14mentioning

confidence: 99%

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Prevalence and Metabolic Factors of Hyperuricemia in an Elderly Agricultural and Fishing Population in Taiwan

Shen

et al. 2017

Arch Rheumatol

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Objectives: This study aims to explore the potential condition-related sex differences to understand the overall pathogenesis of hyperuricemia among the elderly agricultural and fishing population in Taipei, Taiwan. Patients and methods: This study included 4,372 healthy elderly agricultural and fishing professionals (2,766 males, 1,606 females; mean age 74.4±6.6 years; range 65.0 to 90.3 years) voluntarily admitted to a teaching hospital in Taipei, Taiwan for physical exams in 2010. Their fasting blood samples were drawn through venipuncture, and they were administered a structured questionnaire by clinical nurses. Results: The overall prevalence of hyperuricemia was 30.4%, which increased significantly with increasing age (p<0.001). The prevalence was similar in males (30.2%) and females (30.6%) (p=0.78). Age, obesity, type 2 diabetes, hypercholesterolemia, hypertriglyceridemia as well as low high-density lipoprotein and high blood urea nitrogen, creatinine, and alanine amino transferase levels were significantly associated with hyperuricemia. Hypercholesterolemia (odds ratio [OR]=1.26, 95% confidence interval [CI]: 1.05-2.50) and high creatinine levels (OR=3.75, 95% CI: 2.64-5.33) were significantly associated with hyperuricemia in males, whereas type 2 diabetes (OR=1.54, 95% CI: 1.22-1.93) and high alanine amino transferase levels (OR=1.79, 95% CI: 1.31-2.43) were significantly associated with hyperuricemia in females. Hyperuricemia disparity among age groups was also revealed. Conclusion: Several sex-related differences with regard to factors including age, obesity, type 2 diabetes, hypercholesterolemia, hypertriglyceridemia, low high-density lipoprotein, high blood urea nitrogen, creatinine, and alanine amino transferase levels were indicated in the prevalence of hyperuricemia in this specific elderly population.

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Section: 11-14supporting

confidence: 92%

Section: 11-14mentioning

confidence: 99%

Section: 11-14mentioning

confidence: 99%

Section: 11-14mentioning

confidence: 99%

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Prevalence and Metabolic Factors of Hyperuricemia in an Elderly Agricultural and Fishing Population in Taiwan

Shen

et al. 2017

Arch Rheumatol

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“…Our findings were contrary to the earlier reported results of Lin CS et al, where the highest prevalence of HU was reported in 20-39 years of age category, with a subsequent decline in the proportion of HU subjects with age in cases of essential HTN. 8 Various studies have reported higher SUA levels in males than females. 9,10 This may be due to the presence of estrogen in premenopausal females, which enhances renal urate clearance or excretion by inhibition of renal urate reabsorption via organic ion transporter, resulting in low SUA levels.…”

Section: Discussionmentioning

confidence: 99%

A study of the association between hyperuricemia and knee osteoarthritis in the coastal Indian population

et al. 2018

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INTRODUCTIONHyperuricemia is an abnormally high level of uric acid in the blood. In the pH conditions of body fluid, uric acid exists largely as urate, the ion form. The amount of urate in the body depends on the balance between the amount of purines eaten in food, the amount of urate synthesised within the body (e.g. through cell turnover), and the amount of urate that is excreted in urine or through the gastrointestinal tract. In humans, the upper end of the normal range is 6mg/dL (360µmol/L) for women and 6.8mg/dL (400µmol/L) for men. ABSTRACTBackground: Hyperuricemia and knee osteoarthritis are common problems that affect the aging population and they have an increasing prevalence with obesity and hypertension. Epidemiologic and immunological studies have shown a possible relation between the two conditions. Uric acid is a common factor found in association with the evaluation and treatment of osteoarthritis. There are serious therapeutic implications, particularly in using traditional gout medications, for use in osteoarthritis treatment is to be explored in detail. Our diet contains a good amount of purine containing food stuffs. The common items which increase our uric acid levels are red meat, all alcoholic beverages, seafood and shellfish. Previous studies have shown an association between serum uric acid and generalized osteoarthritis, but with the limited studies on the evidence of association between serum uric acid and knee joint osteoarthritis. This study aims to know the association between serum uric acid levels and osteoarthritis of knee joint. Methods: This is a Cross-sectional analytical study including eight hundred and thirty patients (461 males, 369 females) in a population screening during a patient education program on joint pains. Their serum uric acid level, total count, differential count, erythrocyte sedimentation rate (ESR), height, weight, blood pressure, BMI and standing radiographs of affected knees were obtained. The presence of radiographic osteoarthritis of the knee was analyzed using Kellgren-Lawrence system. The patients were divided into cohorts with hyperuricemia and osteoarthritis and compared with the subjects without either of the problems. Results: Isolated knee joint osteoarthritis is present in 183 subjects (22%), hyperuricemia was present in 154 subjects (18.55%). There is a significant positive association present between isolated knee joint osteoarthritis and the highest level of serum uric acid (adjusted odd's ratio-2.24, 95% confidence interval-1.57-2.94). There is a significant positive association between high serum uric acid levels and progression of the knee joint osteoarthritis (highest level versus lowest level of serum uric acid odd's ratio-1.38, 95% confidence interval-0.96-2.74). Conclusions: It is concluded that knee joint osteoarthritis and its progression are associated with hyperuricemia.

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Hyperuricemia and associated factors among hypertensive patients attending an academic hospital of Ethiopia: A cross-sectional study

Philmon Daka,

Bekele Jember,

Hunie Tesfa

2024

Metabolism Open

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Prevalence of hyperuricemia and its association with antihypertensive treatment in hypertensive patients in Taiwan

Cited by 30 publications

References 21 publications

Prevalence and Metabolic Factors of Hyperuricemia in an Elderly Agricultural and Fishing Population in Taiwan

Prevalence and Metabolic Factors of Hyperuricemia in an Elderly Agricultural and Fishing Population in Taiwan

A study of the association between hyperuricemia and knee osteoarthritis in the coastal Indian population

Hyperuricemia and associated factors among hypertensive patients attending an academic hospital of Ethiopia: A cross-sectional study

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