Prevalence of human papillomavirus in archival head and neck cancer in the eastern Inner Mongolian Autonomous Region, China

Abstract

Objective: To investigate the prevalence of human papillomavirus (HPV) in archival head and neck cancer (HNC) collected from the Tong-Liao area, which is located in east Inner Mongolia, China. Methods: The presence of HPV in 54 HNCs and 25 benign biopsies was detected and the sequence variation of the E6 gene in HPV-positive samples was analyzed to determine their lineage/sublineage classification. Results: HPV was detected in only 4 out of 54 HNCs and no benign biopsies were found to be HPV-positive. After further p16INK4a immunostaining, only 3 cases of HNC were positive for both HPV and p16INK4a. Phylogenetic analysis of the isolated E6 gene shows that the HPV 16, HPV 31, and HPV 58 isolated in this study belong to lineage A. Conclusions: The prevalence of HPV in HNC from this area is very low. The lineage/sublineage classification of the 3 HPV types in HNC in this area is consistent with the previous reported data of HPV lineage distribution in cervical cancer within China.

Assessing the burden of HPV-related head and neck cancers in mainland China: protocol of a nationwide, multisite, cross-sectional study

“…Compared with the other mainland China-based studies examining HNC burdens in China,11–13 17 19 BROADEN-China has additional merits. This is the first HPV attributability study in China using the combination of robust testing of HPV DNA, HPV E6*I mRNA and p16 INK4a , which will allow the study to minimise bias associated with sole-HPV testing techniques.…”

“…9 Until today, very few studies have been published in China on the HPV-related HNC disease burden, with the evidence to date limited by small sample sizes and with geographical heterogeneity. [10][11][12][13][14][15][16] In one pooled analysis of data from years 2006-2018, HPV16 prevalence was reported as approximately 24.7% in HNC, 17 with rates of 14.5%-37.0% in different regions of China. More specifically for each anatomical site, other studies showed that HPV positivity is approximately 31.6% in oropharynx, 16.2% in oral cavity, 18 7.6% in larynx, 18 19 6.5% in nasopharynx and 5% in hypopharynx.…”

“…Until today, very few studies have been published in China on the HPV-related HNC disease burden, with the evidence to date limited by small sample sizes and with geographical heterogeneity 10–16. In one pooled analysis of data from years 2006–2018, HPV16 prevalence was reported as approximately 24.7% in HNC,17 with rates of 14.5%–37.0% in different regions of China.…”

História natural da infecção por variantes genéticas de HPV-16 no canal anal de homens participantes do estudo internacional multicêntrico HIM (HPV Infection in Men)

“…6). Among the 14 included studies displayed in Table 1, Africa (Buonaguro et al, 2000), Asia Pham et al, 2018;Wu et al, 2020), North America (Joseph et al, 2013;López-Romero et al, 2013;, Central/South America (Kalantari et al, 2008), and Europe (Tanzi et al, 2009;Tornesello et al, 2008Tornesello et al, , 2010 were represented. One study, by Nicolás-Parraga et al (Nicolás-Párraga et al, 2016), was a multinational study that included samples from 16 countries in Asia, Central/South America, and Europe.…”