Genetic variants of HPV-16 and their geographical and anatomical distribution in men: A systematic review with meta-analysis

Ferreira, Matthew Thomas; Gonçalves, Milena Giulia; López, Rossana Verónica Mendoza; Sichero, Laura

doi:10.1016/j.virol.2021.03.007

Cited by 8 publications

(5 citation statements)

References 32 publications

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“…The distribution of HPV intratype variants varies significantly in different geographical areas [ 23 , 77 , 78 , 79 ]. Nevertheless, there is accumulating evidence showing that non-European HPV-16 variants, have a higher oncogenicity due to their association with high-grade lesions of the cervix and invasive tumors [ 22 , 23 , 24 , 27 , 80 , 81 , 82 , 83 ].…”

Section: Hpv-16 and -18 Intratype Variants And Risk Of Persistence Or...mentioning

confidence: 99%

Epidemiology and Molecular Biology of HPV Variants in Cervical Cancer: The State of the Art in Mexico

Muñoz-Bello

Carrillo-García

Lizano

2022

IJMS

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Cervical cancer (CC) continues to be a major public health problem in Mexico, ranking second among cancers in women. A persistent infection with human papillomaviruses (HPV) is the main risk factor for CC development. In addition, a significant fraction of other cancers including those of the anus, oropharynx, and penis are also related to HPV infection. In CC, HPV-16 is the most prevalent high-risk HPV type, followed by HPV-18, both being responsible for 70% of cases. HPV intratype variant lineages differ in nucleotide sequences by 1–10%, while sublineages differ by 0.5–1%. Several studies have postulated that the nucleotide changes that occur between HPV intratype variants are reflected in functional differences and in pathogenicity. Moreover, it has been demonstrated that HPV-16 and -18 intratype variants differentially affect molecular processes in infected cells, changing their biological behavior that finally impacts in the clinical outcome of patients. Mexico has participated in providing knowledge on the geographical distribution of intratype variants of the most prevalent HPVs in premalignant lesions of the cervix and cervical cancer, as well as in other HPV-related tumors. In addition, functional studies have been carried out to assess the cellular effects of intratype variations in HPV proteins. This review addresses the state of the art on the epidemiology of HPV-16 and HPV-18 intratype variants in the Mexican population, as well as their association with persistence, precancer and cervical cancer, and functional aspects related to their biological behavior.

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Section: Hpv-16 and -18 Intratype Variants And Risk Of Persistence Or...mentioning

confidence: 99%

Epidemiology and Molecular Biology of HPV Variants in Cervical Cancer: The State of the Art in Mexico

Muñoz-Bello

Carrillo-García

Lizano

2022

IJMS

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“…It is important to note that the variations in the viral genome sequence exist below the level of HPV type. These genomic nucleotide differences of 1-10% are called variants, and they have a specific geographic and ethnic distribution [31,[39][40][41]. Several studies have addressed the differences in functional abilities between different HR E6 variants, and some of them were indeed found to be more efficient in target degradation or interaction [42,43].…”

Section: Differences In Genome Organizationmentioning

confidence: 99%

Comparative Analysis of Alpha and Beta HPV E6 Oncoproteins: Insights into Functional Distinctions and Divergent Mechanisms of Pathogenesis

Skelin,

Tomaić

2023

Viruses

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Human papillomaviruses (HPVs) represent a diverse group of DNA viruses that infect epithelial cells of mucosal and cutaneous tissues, leading to a wide spectrum of clinical outcomes. Among various HPVs, alpha (α) and beta (β) types have garnered significant attention due to their associations with human health. α-HPVs are primarily linked to infections of the mucosa, with high-risk subtypes, such as HPV16 and HPV18, being the major etiological agents of cervical and oropharyngeal cancers. In contrast, β-HPVs are predominantly associated with cutaneous infections and are commonly found on healthy skin. However, certain β-types, notably HPV5 and HPV8, have been implicated in the development of non-melanoma skin cancers in immunocompromised individuals, highlighting their potential role in pathogenicity. In this review, we comprehensively analyze the similarities and differences between α- and β-HPV E6 oncoproteins, one of the major drivers of viral replication and cellular transformation, and how these impact viral fitness and the capacity to induce malignancy. In particular, we compare the mechanisms these oncoproteins use to modulate common cellular processes—apoptosis, DNA damage repair, cell differentiation, and the immune response—further shedding light on their shared and distinct features, which enable them to replicate at divergent locations of the human body and cause different types of cancer.

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“…Volpini et al (2017) investigated the HPV 16 variants in anal samples collated in Brazil, finding that 70.8% were classified as A1–3 sub-lineages and 29.2% as “other” [ 12 ]. A recent systematic review, performed by Ferreira et al (2021) of genetic variants of HPV-16 in men, found HPV 16 lineages vary according to anatomical and geographical regions, but they found that European samples had a high prevalence (86.59%) of HPV 16 lineage A [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Mapping HPV 16 Sub-Lineages in Anal Cancer and Implications for Disease Outcomes

et al. 2022

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The incidence of anal cancer is rising worldwide. As identified in cervical cancer management, an improvement in the early detection and management of anal pre-cancer is essential. In other cancers associated with human papillomavirus (HPV), HPV 16 sub-lineages have been shown to be associated with disease status and prognosis. However, in anal cancer, they have been under-explored. A total of 119 HPV 16-positive anal cancer lesions diagnosed between 2009 and 2018 in Scotland and 134 HPV 16-positive residual rectal swabs from asymptomatic men collected in 2016/7 were whole genome sequenced. The association of HPV 16 sub-lineages with underlying disease status (cancer vs. asymptomatic) and overall survival in anal cancer samples was assessed (comparing A1 vs non-A1 sub-lineages). A1 was the dominant sub-lineage present in the anal cancer (76.5%) and the asymptomatic (76.1%) cohorts. A2 was the second most dominant sub-lineage in both groups (16.8% and 17.2%, respectively). We did not observe significant associations of sub-lineage with demographics, clinical variables or survival (A1 vs. non-A1 sub-lineages (HR 0.83, 0.28–2.46 p = 0.743)). HPV 16 sub-lineages do to not appear to cluster with disease vs asymptomatic carriage or be independently associated with outcomes in anal cancer patients. Further international studies on anal HPV sub-lineage mapping will help to determine whether this is a consistent observation.

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Genetic variants of HPV-16 and their geographical and anatomical distribution in men: A systematic review with meta-analysis

Cited by 8 publications

References 32 publications

Epidemiology and Molecular Biology of HPV Variants in Cervical Cancer: The State of the Art in Mexico

Epidemiology and Molecular Biology of HPV Variants in Cervical Cancer: The State of the Art in Mexico

Comparative Analysis of Alpha and Beta HPV E6 Oncoproteins: Insights into Functional Distinctions and Divergent Mechanisms of Pathogenesis

Mapping HPV 16 Sub-Lineages in Anal Cancer and Implications for Disease Outcomes

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