Prevalence of human papillomavirus genotypes and precancerous cervical lesions in a screening population in Beijing, China: Analysis of results from China’s Top 3 Hospital, 2009–2019

Abstract

Background: Cervical cancer is the fourth most common cancer in women. Early detection and diagnosis play an important role in secondary prevention of cervical cancer. This study aims to provide more information to develop an effective strategy for the prevention and control of cervical cancer in northern China. Methods: A retrospective single-centre descriptive cross-sectional study was conducted in Chinese PLA General Hospital located in Beijing, covering the period from January 2009 to June 2019. The patients who underwent a polymerase chain reaction (PCR)-based HPV genotyping test and cervical pathological diagnosis were included. Furthermore, we limited the interval between the two examination within 180 days for the purpose of making sure their correlation to analyse their relationship. Moreover, the relationship between different cervical lesions and age as well as single/multiple HPV infection was assessed.Results: A total of 3,134 patients were eligible in this study after HPV genotyping test and pathological diagnosis. Most of the patients (95%) were from northern China. Among the patients, 1,745(55.68%） had high-grade squamous intraepithelial neoplasia (HSIL), 1,354 (43.20%) had low-grade squamous intraepithelial neoplasia (LSIL) and 35 (1.12%) were Normal. The mean age was 42.06 ± 10.82(range, 17–79 years). The women aged 35-49 years accounted for the highest incidence rate. The top five most commonly identified HPV genotypes in each lesion class were as follows: HPV16, 58, 52, 31 and 51 in the class of HSIL; HPV16, 52, 58, 56 and 51 in the class of LSIL; HPV16, 31, 6,11, 52 and 58 in the class of normal. The frequencies of HPV single genotype infection and multiple genotypes infection were 55.26% and 34.18%, respectively. There was no difference in the attributable proportions of multiple genotypes infection amongst HSIL, LSIL and Normal.Conclusions: In Northern China, HPV16 was the most dominant genotype in the patients with pathological examination. The peak age of the onset of HSIL was between 35 and 49 years of age. Infection with multiple HPV genotypes did not increase the risk of HSIL. Type-specific HPV prevalence and attribution proportion to cervical precancerous lesions should be taken into consideration in the development of vaccines and strategy for screening in this population.

Association Between GSDMB Gene Polymorphism and Cervical Cancer in the Northeast Chinese Han Population

“…Our results replicated previous studies and showed that the average age of the CC group was 49.33 ± 9.29 years, and the average age of the SIL group was 42.22 ± 9.68 years. This is consistent with the conclusion that the peak of CC in the Chinese mainland is 40-60 years old and the peak of SIL is 30-50 years old (Wang et al, 2018;Liu et al, 2020). This may be related to the fact that women in the 30-40 age group are in the period of sexual activity and childbearing, while most of the women after the age of 50 are postmenopausal (Misra et al, 2018).…”

Prevalence of Multiple High Risk Human Papilloma Virus (HR-HPV) Infections in Cervical Cancer Screening in Lazio Region, Italy

“…Extended HR-HPV genotyping showed that often multiple genotypes can coexist within the cervical epithelia (11)(12)(13). From literature data, it emerges that although some works do not observe a relation between co-infections and cervical lesions (14,15), several studies have demonstrated that infections with multiple HR-HPV increase the neoplastic transformation risk (16,17). Furthermore, neoplasms with multiple HR-HPVs could be more resistant to therapy than those with a single infection.…”