Prevalence of Human Papillomavirus Genotypes in Routine Pap Smear of 2,562 Korean Women Determined by PCR-DNA Sequencing

KyungOk, Lee; Jeong, Su-Jin; Park, Min-Young; Seong, Hye-Soon; Shin, Eun-Sim; Choi, Kyeong-Hwan; Kim, Gee-Young; Lee, Sun-Hwa

doi:10.4167/jbv.2009.39.4.337

Cited by 3 publications

(2 citation statements)

References 30 publications

(22 reference statements)

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“…At the same time this discordance may be the explanation of erroneous false positive diagnosis of abnormal cytological results. The present study clearly demonstrates the presence of peak of HR-HPV infection in relation to age, with increasing the prevalence of HR-HPV infection with advancing age until reaches the peak in the age group (21)(22)(23)(24)(25)(26)(27)(28)(29)(30) years then decline after that. In general, it is well observed worldwide that the prevalence estimates of HPV infections are age dependant and shows three patterns of distributions.…”

Section: Resultssupporting

confidence: 65%

“…(Table 4) show distribution of HR-HPV positivity with regard to grading of cervical abnormality, the prevalence of HR-HPV infection rate increases with increasing the grade of abnormality reaching to (80%) and (87.5%) in cases of LSIL and HSIL respectively, while the positivity for ASC-US was ranking (45.9%), which was significantly less (P-value=0.029), although the positivity in cases of HSIL was more than in the cases of LSIL the difference was statistically not significant (P-value =0.671). (10) PCR 40% Baghdad (Salih et al) (11) Hybrid capture II 49% Baghdad(Alwan et al) (12) PCR 50.5% Baghdad(Fadhil et al) (13) PCR 60% Basrah (Fahad et al) (14) PCR 53% Saudi Arabia (15) PCR 60% Iran (16) PCR 78% Turkey (17) Hybrid capture II 68.4% Taiwan (18) PCR 76.5% Equador (19) PCR 83.8% Cameroon (20) Hybrid capture II 35.1% China (21) PCR 65.4% Korea (22) PCR 84.2% Canada (23) PCR 82.6% Guatemala (24) Discussion:…”

Section: Resultsmentioning

confidence: 99%

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Prevalence of Human Papillomavirus in Women with Abnormal Pap Smears

Mahmoud¹,

Rifat²

2021

KJMS

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Human papillomavirus (HPV) is a widely prevalent sexually transmitted virus. Although the majority of infections are benign and transient, persistent infection is associated with the development of cervical, vulvar, vaginal and anal cancers (1) .The genital HPV types are divided into two categories, 'high risk' and 'low risk', originally assigned based on whether the HPV type could or could not be found as a solitary isolate in cervical cancer specimens (2) . It is now universally accepted that nearly all the invasive cervical cancers and high grade intraepithelial neoplasia and

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Section: Resultssupporting

confidence: 65%

Section: Resultsmentioning

confidence: 99%

Prevalence of Human Papillomavirus in Women with Abnormal Pap Smears

Mahmoud¹,

Rifat²

2021

KJMS

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Enhanced disease progression due to persistent HPV-16/58 infections in Korean women: a systematic review and the Korea HPV cohort study

Seong

Ryou

Lee

et al. 2021

Virol J

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Background Persistent human papillomavirus (HPV) infection is a key factor for the development and progression of cervical cancer. We sought to identify the type-specific HPV prevalence by cervical cytology and assess disease progression risk based on high-risk persistent HPV infection in South Korea. Methods To investigate the HPV prevalence by Pap results, we searched seven literature databases without any language or date restrictions until July 17, 2019. To estimate the risk of disease progression by HPV type, we used the Korea HPV Cohort study data. The search included the terms “HPV” and “Genotype” and “Korea.” Studies on Korean women, type-specific HPV distribution by cytological findings, and detailed methodological description of the detection assay were included. We assessed the risk of disease progression according to the high-risk HPV type related to the nonavalent vaccine and associated persistent infections in 686 HPV-positive women with atypical squamous cells of uncertain significance or low-grade squamous intraepithelial lesions from the Korea HPV Cohort Study. Type-specific HPV prevalence was the proportion of women positive for a specific HPV genotype among all HPV-positive women tested for that genotype in the systematic review. Results We included 23 studies in our review. HPV-16 was the most prevalent, followed by HPV-58, -53, -70, -18, and -68. In women with high-grade squamous intraepithelial lesions, including cancer, HPV-16, -18, and -58 were the most prevalent. In the longitudinal cohort study, the adjusted hazard ratio of disease progression from atypical squamous cells of uncertain significance to high-grade squamous intraepithelial lesions was significantly higher among those with persistent HPV-58 (increase in risk: 3.54–5.84) and HPV-16 (2.64–5.04) infections. Conclusions While HPV-16 was the most prevalent, persistent infections of HPV-16/58 increased the risk of disease progression to high-grade squamous intraepithelial lesions. Therefore, persistent infections of HPV-16 and -58 are critical risk factors for cervical disease progression in Korea. Our results suggest that equal attention should be paid to HPV-58 and -16 infections and provide important evidence to assist in planning the National Immunization Program in Korea.

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Detection and Genotyping of Human Papillomavirus in Cervical Tissue Samples in Ahvaz, Southwest Iran

Hamidi-Fard¹,

Fattahi-Abdizadeh²,

Makvandi³

et al. 2012

Jundishapur J Microbiol

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Background: 500,000 new cases with progressive cancer of cervix are reported worldwide annually. This malignant cancer is the second common cancer among females. Human papillomavirus (HPV) is considered as the major cause of cervical cancer and dysplasia. PCR Application to detect the HPV DNA in clinical specimens besides microscopic examination of cervical biopsy (Papanicolaou smear) (Pap smear) are valuable prognostic indicators in cervical cancer management. Objectives: Due to the absence of epidemiological data on prevalence and distribution of HPV genotypes in Khuzestan province, the authors decided to conduct a research to determine the HPV genotypes in cases with a degree of cervical dysplasia. Materials and Methods: In this study, 60 samples of paraffin-embedded biopsy samples archived in the library of pathology laboratory of Ahvaz Imam Khomeini hospital were selected for further experiments. After DNA extraction of each specimen, the infection of the tissue with HPV was confirmed by PCR. PCR products were sequenced to detect HPV genotypes. Results: Out of 60 cervical biopsy samples, 8 (%13.3) cases were HPV DNA positive. Four (%50) were genotype 16 positive, 2 (%25) were genotype 6 positive, 1(%12.5) sample was detected as the genotype 18 and 1 of the positive cases was genotype 11 of HPV. Conclusions: Our study shows that prevalence of HPV infection in cervical biopsy samples collected from suspected patients in Khouzestan province is slightly higher than other provinces of Iran. Since HPV cervical infection, is an indicator for the host cervical cancer progression, parallel with Pap smear test, PCR detection of HPV DNA in biopsy of suspected cases is recommended.

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Prevalence of Human Papillomavirus Genotypes in Routine Pap Smear of 2,562 Korean Women Determined by PCR-DNA Sequencing

Cited by 3 publications

References 30 publications

Prevalence of Human Papillomavirus in Women with Abnormal Pap Smears

Prevalence of Human Papillomavirus in Women with Abnormal Pap Smears

Enhanced disease progression due to persistent HPV-16/58 infections in Korean women: a systematic review and the Korea HPV cohort study

Detection and Genotyping of Human Papillomavirus in Cervical Tissue Samples in Ahvaz, Southwest Iran

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