Prevalence of HPV infection among clinically healthy Italian males and genotype concordance between stable sexual partners

Lorenzon, Laura; Terrenato, Irene; Donà, Maria Gabriella; Ronchetti, Livia; Rollo, Francesca; Marandino, Ferdinando; Carosi, Mariantonia; Diodoro, Maria Grazia; Sentinelli, Steno; Visca, P.; Vocaturo, Giuseppe; Bellardini, P.; Vocaturo, Amina; Benevolo, Maria

doi:10.1016/j.jcv.2014.04.003

Cited by 21 publications

(20 citation statements)

References 33 publications

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“…From a socio-epidemiological standpoint, it is important to note that HPV-infected men play a key role in the transmission of the HPV virus to their female sexual partners. The range reported in other studies for sexual partners of women with CIN was 30-68% [19,24,26,36,38]. Geographical region, anatomical sampling site, or HPV detection methods have not explained the wide heterogeneity of results [27].…”

Section: Hr-hpv Prevalence In Heterosexual Men Populationsmentioning

confidence: 81%

“…Number of types tested for varies between articles. In studies reporting prevalence estimates for more than one HPV type, the commonest detected types were HPV16 [20,24,26,27,36,37] and HPV18 [27].…”

Section: Hr-hpv Prevalence In Heterosexual Men Populationsmentioning

confidence: 99%

“…HPV concordance in heterosexual couples has important clinical and public health implications. In terms of HR-HPV detection, the percentage of couples harboring HR-HPV was 32-65% [28,36,37,41]. In couples where both members were HPV positive, more than 60% were infected with one or more of the same HPV types.…”

Section: Concordance Between Sexual Partnersmentioning

confidence: 99%

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Diagnosis and Prevalence of High-Risk Human Papillomavirus Infection in Heterosexual Men

López-Diez¹,

Pérez²,

Iñarrea³

2016

Human Papillomavirus - Research in a Global Perspective

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A better understanding of human papillomavirus (HPV) infection in men is an essential component of prevention programs aimed to reduce cervical cancer and other HPVrelated diseases. A screening test capable of detecting asymptomatic/subclinical genital HPV infection in men at a reasonable price and causing minimal discomfort to the patient would be very valuable. The following chapter focuses on acetowhite test usefulness in the detection of asymptomatic/subclinical genital high-risk (HR) HPV infection in highrisk men populations, HR-HPV prevalence in sexually active healthy male partners of women diagnosed of high-grade cervical intraepithelial neoplasia and genotypespecific concordance between partners, addressing the preventive strategies that would reduce HPV infection in men. We present data from 125 men, sexual partners of women with preneoplastic cervical lesions. Prevalence of HR-HPV infection in male was high (50, 24% HPV16) and genotype concordance within the 60 infected couples was remarkable (62% shared at least one genotype). Acetowhite (AW) test was positive in 27% patients, showing low sensitivity for the identification of HR-HPV infection but allowed the diagnosis of subclinical HPV-related lesions in more than 10%. Current smoking and genital warts were associated with an increased risk of HR-HPV infection in men (OR: 2.4 and 5.6, respectively).

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Section: Hr-hpv Prevalence In Heterosexual Men Populationsmentioning

confidence: 81%

Section: Hr-hpv Prevalence In Heterosexual Men Populationsmentioning

confidence: 99%

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Diagnosis and Prevalence of High-Risk Human Papillomavirus Infection in Heterosexual Men

López-Diez¹,

Pérez²,

Iñarrea³

2016

Human Papillomavirus - Research in a Global Perspective

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“…1 The prevalence of the HPV infection in Europe is 12.4% in the general population 2 and in Italy 72% and 40.5% male partners of HPV-positive women are positive for genital HPV infection. 3,4 HPV can cause cervical cancer, cancers of the vulva and vagina in women, penile cancer in men, as well other anogenital cancer, oropharyngeal cancer, and genital warts in both sexes. 5,6 Vaccination against HPV infection has been recognized as an effective primary intervention to prevent cervical, vaginal, and vulvar precancerous lesions in women and highly efficacious for preventing penile precancers and for reducing the burden of HPV related diseases in men.…”

Section: Introductionmentioning

confidence: 99%

Human papillomavirus infection and vaccination: Knowledge and attitudes among young males in Italy

Napolitano

Liguori

et al. 2016

Human Vaccines & Immunotherapeutics

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This study assessed knowledge and attitudes about Human papillomavirus (HPV) and the relative vaccination and their determinants in a sample of young males. The survey was conducted between January and April 2015 among a sample of 1000 males aged between 14-24 y in the geographic area of Naples and Caserta, Italy. The 54.9% of the participants reported of having heard about the HPV infection. Those who were aware about the availability of the vaccine, who reported the first vaginal sexual encounter before the 18 y and at least at 18 y compared to those who had not had a complete sexual intercourse, who had undergone a health checkup in the last year, and who had received information about the HPV vaccine by physicians had a significant higher knowledge about the HPV infection. The 58.2% reported that they would be willing to receive the HPV vaccine. Those younger, who reported the first vaginal sexual encounter at least at 18 y, who agreed that male should receive the vaccine, who knew that both males and females can acquire the infection, and who agreed that the vaccine is an important preventive intervention, expressed more positive attitude toward willingness to receive the vaccine. More information about the HPV vaccine were required by those who agreed that the vaccine is an important preventive intervention, who reported the first vaginal sexual encounter at least at 18 y, who have had only one partner in the last year compared to students who had no partner, and who had received information about the vaccine by physicians. This study highlights a need for improved education of young males of the HPV infection and the associated diseases and about the benefit of the vaccination.

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“…Among low‐risk men, the reported HPV prevalences were 8.0% in Japan and 8.7% in South Korea, compared to 25.8–42.8% in the USA, 33.8% in Denmark, 54% in Kenya, and 84% in Chile [Smith et al, ]. Among high‐risk men, HPV prevalences were 13.8% in China and 18.5–48% in Japan [Shigehara et al, ; Smith et al, ], compared to 68.8% in Argentina, 28.2% in the USA, 40.5–72% in Italy, and 70.4% in Africa [Smith et al, ; Grabowski et al, ; Lorenzon et al, ]. Thus, HPV prevalence among men also varies according to geographic area and population ethnicity.…”

Section: Introductionmentioning

confidence: 99%

Human papillomavirus infection in male patients with STI‐related symptoms in Hanoi, Vietnam

Ishizaki

et al. 2015

Journal of Medical Virology

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This cross-sectional study investigated the prevalence, genotypes, and risk factors for human papillomavirus (HPV) infection in Hanoi, Vietnam. The study included 192 males (mean age, 32.9 years) with symptoms related to sexually transmitted infections (STI). Urinary, penile, and urethral samples were collected in April and May, 2014. HPV DNA was detected with PCR, performed with modified and/or original GP5(+)/GP6(+) primers. HPV genotypes were determined with a gene array assay. Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) DNA were detected with loop-mediated isothermal amplification. HPV DNA, NG, and CT were detected in 48 (25.0%), 23 (12.0%), and 41 (21.4%) patients, respectively. HPV DNA appeared in penile samples (21.0%, 39/186) more frequently than in urinary (3.1%, 6/191, P < 0.001) and urethral (9.4%, 18/192, P = 0.002) samples. Among patients with HPV, genotype prevalence was: HPV81 (22.9%), HPV52 (18.8%), HPV18 (16.7%), and HPV16 (6.3%). Multiple-type and high risk-type HPV infections were determined in 33.3% and 64.6%, respectively. Multivariate analysis showed a significant association of HPV infection in urethra with younger sexual debut age. HPV52 was the most prevalent high-risk HPV genotype, whereas HPV16 was less common in the male Vietnamese patients with STI-related symptoms. Younger sexual-debut age was a risk factor for HPV infection in urethra.

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Prevalence of HPV infection among clinically healthy Italian males and genotype concordance between stable sexual partners

Cited by 21 publications

References 33 publications

Diagnosis and Prevalence of High-Risk Human Papillomavirus Infection in Heterosexual Men

Diagnosis and Prevalence of High-Risk Human Papillomavirus Infection in Heterosexual Men

Human papillomavirus infection and vaccination: Knowledge and attitudes among young males in Italy

Human papillomavirus infection in male patients with STI‐related symptoms in Hanoi, Vietnam

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