Human papillomavirus infection in male patients with STI‐related symptoms in Hanoi, Vietnam

Le, Hai Thanh; Bi, Xiuqiong; Ishizaki, Azumi; Le, Hung V.; Nguyen, Trung Vu; Hosaka, Norimitsu; Ishiguro, Hiroshi

doi:10.1002/jmv.24422

Cited by 14 publications

(28 citation statements)

References 26 publications

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“…In a recent cross-sectional study, HPV DNA was detected in 25% of male Vietnamese patients with symptoms related to sexually transmitted infections. HPV52 was the most prevalent high-risk HPV genotype, whereas HPV16 was less common in this study27.…”

Section: Discussionmentioning

confidence: 52%

A functional polymorphism in the NKG2D gene modulates NK-cell cytotoxicity and is associated with susceptibility to Human Papilloma Virus-related cancers

Espinoza

Nguyễn

Ishiguro

et al. 2016

Sci Rep

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Human papillomavirus (HPV) is the most common sexually transmitted agent worldwide and is etiologically linked to several cancers, including cervical and genital cancers. NKG2D, an activating receptor expressed by NK cells, plays an important role in cancer immune-surveillance. We analyzed the impact of a NKG2D gene variant, rs1049174, on the incidence of HPV-related cancers in Vietnamese patients and utilized various molecular approaches to elucidate the mechanisms of NKG2D receptor regulation by rs1049174. In a group of 123 patients with HPV+ anogenital cancers, the low cytotoxicity allele LNK was significantly associated with increased cancer susceptibility (p = 0.016). Similar results were also observed in a group of 153 women with cervical cancer (p = 0.05). In functional studies, NK cells from individuals with LNK genotype showed a lower NKG2D expression and displayed less efficient NKG2D-mediated functions than NK cells with HNK genotype. Notably, the rs1049174 variant occurs within a targeting site for miR-1245, a negative regulator of NKG2D expression. Compared with the higher cytotoxicity allele HNK, the LNK allele was more efficiently targeted by miR-1245 and thus determined lower NKG2D expression in NK cells with the LNK genotype. The NKG2D variants may influence cancer immunosurveillance and thus determine susceptibility to various malignancies, including HPV-induced cancers.

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Section: Discussionmentioning

confidence: 52%

A functional polymorphism in the NKG2D gene modulates NK-cell cytotoxicity and is associated with susceptibility to Human Papilloma Virus-related cancers

Espinoza

Nguyễn

Ishiguro

et al. 2016

Sci Rep

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“…Penile, urethral, and urinary samples were collected from the 210 patients, as described previously [14]. Briefly, penile and urethral swabs were obtained with nylon tips soaked in saline solution (FLOQSwab R100 and FLOQSwab U80, respectively; Copan Diagnostics Inc., Murrieta, CA).…”

Section: Methodsmentioning

confidence: 99%

“…Urinary and oral samples were centrifuged at 1500 g for 10 min, and the cell pellets were resuspended in 3 ml and 2.5 ml of LiquiPrep solution, respectively. These samples were stored at 4 °C until use [14, 18].…”

Section: Methodsmentioning

confidence: 99%

“…In Vietnam, there is limited information on genital HPV infections among men. It was reported that the prevalence of HPV was 25.0% among male patients with STIs; moreover, HPV52 (18.8%) was the most prevalent high-risk genotype, followed by HPV18 (16.7%) and HPV16 (6.3%) [14]. The prevalence of HPV was 23.0–79.6% among patients with penile cancer, and HPV16 (67.4–89.0%) was the most prevalent high-risk genotype [15, 16].…”

Section: Introductionmentioning

confidence: 99%

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Low concordance of oral and genital HPV infection among male patients with sexually transmitted infections in Vietnam

Ishizaki

et al. 2019

BMC Infect Dis

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Background Human papillomavirus (HPV) causes cancers in men, including penile, anal, and oropharyngeal cancers. This cross-sectional study aimed to investigate the prevalence, the genotypes, and the risk factors of HPV infections in the oral cavity, compared to those in the genitals, among males diagnosed with sexually transmitted infections (STIs) in Vietnam. Methods Oral, urinary, penile, and urethral samples were collected from 198 male Vietnamese patients with STIs (median age 31.0 years, range 17–68). HPV DNA was isolated and amplified with PCR, with modified and/or original GP5 + /GP6 + primers. Samples were genotyped with a gene array assay and/or population sequencing. Results HPV DNA was detected in 69 (34.8%) of 198 patients. Of these, 16 patients (8.1%) had infections in the oral cavity and 58 (29.3%) had infections in the genitals (4.5% in the urine, 25.8% in the penis, and 8.1% in the urethra). The concordance of HPV infections between the oral cavity and the genitals was poor (kappa = 0.01). Of the 16 patients with oral HPV DNA, 11 (68.8%) had no HPV DNA in the genitals. In the remaining five patients, HPV DNA was found at both sites, but only one showed similar strains at both sites. In the other four patients, the HPV genotypes were completely discordant between these sites. HPV18 was the most common high-risk HPV genotype in both oral (9/16, 56.3%) and genital (10/58, 17.2%) sites. Multivariable analyses showed that older age (OR 1.05), higher education (OR 2.17), and no knowledge of STIs (OR 4.21) were independent risk factors for genital HPV infections; in contrast, only older age (OR 1.05) was an independent risk factor for oral HPV infections. Conclusions The low concordance of HPV genotypes between oral and genital infection sites suggested that the acquisition, persistence, and/or clearance of HPV infections were different between these sites. Although HPV DNA was detected significantly less frequently in oral samples than in genital samples, oral samples should also be used for HPV screening in men. Electronic supplementary material The online version of this article (10.1186/s12879-019-4175-0) contains supplementary material, which is available to authorized users.

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“…5 HPVs preferentially infect the mucosa of the genitals, upper-respiratory tract, and the skin, 6 and they are recognized as important pathogenic factors of cervical cancer and precancerous lesions. 6,7 Based on the association of HPV with cervical cancer or the risk of carcinogenesis, all HPV genotypes can be divided into different subgroups of mucosal HPVs: high-risk types of HPVs (HR-HPV), such as HPVs 16,18,31,33,35,39,45,51,52,56,58,59,68,73,and 82, which are classified as carcinogenic to humans 5,8 ; low-risk types of HPVs (LR-HPV), such as HPVs 6,11,28,32,40,42,43,44,54,55,57,61,62,71,72,74,81,83,84,86,87, and 89; probable/possible HR-HPVs (pHR-HPV), such as HPVs 68, 26, 53, 66, 82, 70, 67, and 73. 5 The HR-HPVs are the causes of approximately 5% of all cancers in humans and one-third of all virus-induced tumors.…”

Section: Introductionmentioning

confidence: 99%

Distribution characteristics of different human papillomavirus genotypes in women in Wuhan, China

Xiang

Guan

Liu

et al. 2018

Clinical Laboratory Analysis

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BackgroundHuman papillomaviruses (HPVs) are strongly associated with the development of cervical carcinoma, and the distribution of HPV genotypes varies regionally.MethodsTo investigate the distribution characteristics of different genotypes of HPV infection in women in Wuhan, China, a total of 13 775 patients were enrolled over 2 years.ResultsOf these, 2436 patients were infected with HPVs, and the total infection rate was 17.68%. The infection rate of high‐risk HPV (HR‐HPV) was significantly higher (13.96%) than that of single low‐risk HPV (LR‐HPV; 3.72%). Among the HR‐HPV infections, the most common genotype was HPV 52 with an infection rate of 4.23%, followed by HPVs 16, 58, 39, and 51. The most common LR‐HPV genotype was HPV 81, followed by HPVs 6, 11, and 44. Patients under the age of 25 years were found to have the highest HPV infection rate (P < .05). After the age range of 51‐55 years, a downward trend in total HPVs and HR‐HPVs was observed. The HPV infection rate for a single genotype was higher than that for multiple HPVs (P < .01), and the detection rates in summer and winter were significantly higher than those in spring and autumn.ConclusionsThe results demonstrate that the distribution characteristics of various HPV genotype infections are associated with region and age and may be related to season. These data could be the basis for further epidemiological analysis into the control and prevention of HPV infection in this region.

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Human papillomavirus infection in male patients with STI‐related symptoms in Hanoi, Vietnam

Cited by 14 publications

References 26 publications

A functional polymorphism in the NKG2D gene modulates NK-cell cytotoxicity and is associated with susceptibility to Human Papilloma Virus-related cancers

A functional polymorphism in the NKG2D gene modulates NK-cell cytotoxicity and is associated with susceptibility to Human Papilloma Virus-related cancers

Low concordance of oral and genital HPV infection among male patients with sexually transmitted infections in Vietnam

Distribution characteristics of different human papillomavirus genotypes in women in Wuhan, China

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