Prevalence of HIV-associated neurocognitive disorders in the Multicenter AIDS Cohort Study

Sacktor, Ned; Skolasky, Richard L.; Seaberg, Eric C.; Munro, Cynthia A.; Becker, James T.; Martin, Eileen; Ragin, Ann B.; Levine, Andrew J.; Miller, Eric N.

doi:10.1212/wnl.0000000000002277

Cited by 312 publications

(255 citation statements)

References 16 publications

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“…These results confirm what has been previously showed in cART experienced elderly HIV-infected subjects, where a mixed cortical-subcortical phenotype of impairment could be detected [9,41,42]. No cases of severe depression were found, thus reducing risks for confounding behavioural disorders.…”

Section: Discussionsupporting

confidence: 91%

Evaluation of Three Brief Screening Tests for Older Patients with Mild HIVAssociated Neurocognitive Disorders in the cART Era

Vassallo¹,

Barbaud²,

Fabre³

et al. 2017

J Neurol Neurophysiol

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Section: Discussionsupporting

confidence: 91%

Evaluation of Three Brief Screening Tests for Older Patients with Mild HIVAssociated Neurocognitive Disorders in the cART Era

Vassallo¹,

Barbaud²,

Fabre³

et al. 2017

J Neurol Neurophysiol

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“…(28) . No entanto, independentemente das diferentes opiniões, a forma de HAND sem repercussão funcional na vida diária (comprometimento neurocognitivo assintomático) ainda é o subtipo mais frequente observado (5,22,24,28) . …”

Section: Discussionunclassified

“…O perfil das manifestações neurocognitivas mudou drasticamente após a era HAART, caracterizando-se por uma incidência reduzida de HAD e aumento de MND e ANI (5,22) .…”

Section: B Hiv E Alterações Neurocognitivasunclassified

“…Atualmente, estimam-se prevalências de 15-30% para ANI, 20-50% para MND e 2-8% para HAD (5,22,24,25) . Esses dados são constantes independentemente do local estudado, indo ao encontro com alguns pesquisadores que sugerem que a metade dos pacientes infectados com HIV na Europa e nos EUA podem ter algum comprometimento cognitivo, com predominância da forma assintomática (3) .…”

Section: B Hiv E Alterações Neurocognitivasunclassified

“…entretanto, as alterações cognitivas permanecem comuns aos pacientes aderentes, sem necessariamente terem tido doenças oportunistas (2)(3)(4)(5)(6)(7)9,11,22) . Diante deste cenário, faz-se …”

Section: Justificativa Do Estudounclassified

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Prevalência de alterações neurocognitivas associadas ao HIV em uma coorte aderente ao antirretroviral em um hospital geral na cidade de São Paulo

Lima¹

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Association of Brain Structure Changes and Cognitive Function With Combination Antiretroviral Therapy in HIV-Positive Individuals

et al. 2018

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IMPORTANCE Despite the introduction of combination antiretroviral therapy (cART), HIV-associated neurocognitive disorders continue to be a problem for treated HIV-positive individuals. The cause of this impairment remains unclear.OBJECTIVE To determine if detectable brain changes occur during a 2-year period in HIV-positive individuals who were aviremic and treated with cART. DESIGN, SETTING, AND PARTICIPANTSIn this longitudinal case-control study, participants underwent neuroimaging and neuropsychological assessment approximately 2 years apart. Data were collected from October 26, 2011, to March 1, 2016. Data from 92 HIV-positive individuals were acquired at Washington University in St Louis from ongoing studies conducted in the infectious disease clinic and AIDS Clinical Trial Unit. A total of 55 HIV-negative control participants were recruited from the St Louis community and a research participant registry. A total of 48 HIV-positive individuals who were aviremic and treated with cART and 31 demographically similar HIV-negative controls met the study requirements and were included in the analyses.MAIN OUTCOMES AND MEASURES Brain volumes were extracted with tensor-based and voxel-based morphometry and cortical modeling. Raw scores from neuropsychological tests quantified cognitive performance. Multivariable mixed-effects models assessed the effect of HIV serostatus on brain volumes and cognitive performance, and determined if HIV serostatus affected how these measures changed over time. With HIV-positive participants, linear regression models tested whether brain volumes and cognitive performance were associated with measures of infection severity and duration of infection.

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Prevalence of HIV-associated neurocognitive disorders in the Multicenter AIDS Cohort Study

Cited by 312 publications

References 16 publications

Evaluation of Three Brief Screening Tests for Older Patients with Mild HIVAssociated Neurocognitive Disorders in the cART Era

Evaluation of Three Brief Screening Tests for Older Patients with Mild HIVAssociated Neurocognitive Disorders in the cART Era

Prevalência de alterações neurocognitivas associadas ao HIV em uma coorte aderente ao antirretroviral em um hospital geral na cidade de São Paulo

Association of Brain Structure Changes and Cognitive Function With Combination Antiretroviral Therapy in HIV-Positive Individuals

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