Prevalence of hereditary non polyposis colon cancer (HNPCC) in South Italy: A prospective investigation

Riegler, G.; Savastano, Alfonso; Gagliardi, Giovanna; Carratù, R.; Borgheresi, P.; Piscitelli, A.; Rossi, Giuseppina; Bianco, M.A.; Montanaro, Fabio; Cattaneo, Daniela; Pezzullo, Angelo Maria; Sessa, Edoardo; Giorgio, P. Di; Baldi, V.; Stefano, S. De; Palma, G.D. De; Guardascione, F.; Spinelli, P; Selvaggi, Fp; Pastore, Pietro; Saffiotti, O; Martorano, Marco; Morella, P; Parente, Elisabetta; Bozzi, Maurizio; Iorio, R.

doi:10.1016/0016-5085(95)26427-2

Cited by 2 publications

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“…There have been a number of attempts to estimate the relative burden of HNPCC cases in the overall incidence of CRC 9 –15 . A number of potential biases in these studies exist.…”

Section: The Definition Of Hnpccmentioning

confidence: 99%

“…More recent data has tended to suggest that the estimates given above may be overstating the prevalence of HNPCC. A small study from the south of Italy reported that two of 252 (0.79%) prospectively assessed index CRC cases fulfilled the Amsterdam criteria 14 . Following up their previously reported population‐based data, Mecklin et al have reported the results of a prospective multicentre study designed to assess the incidence of HNPCC in Finland 15 .…”

Section: The Definition Of Hnpccmentioning

confidence: 99%

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Hereditary Non‐polyposis Colorectal Cancer Syndrome

Moore

Cowled

1999

Aust. N.Z. J. Surg.

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Hereditary non-polyposis colorectal cancer (HNPCC) syndrome may account for up to 4% of the total colorectal cancer burden in our community. It is assuming an increasingly important role, both as a clinical management issue and as a model for the application of laboratory and clinical genetic services in cancer detection and prevention. Recent developments in the understanding of the molecular biology of the condition have underpinned recommendations for consideration of genetic testing for DNA mismatch repair gene mutation, recommendations that may have far-reaching implications in terms of the numbers of patients offered genetic testing and for associated costs (both financial and psychological). The aim of this review is to highlight the clinical, pathologic and molecular biologic features of HNPCC that underlie the clinical management of affected index patients and their at-risk family members.

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“…There have been a number of attempts to estimate the relative burden of HNPCC cases in the overall incidence of CRC 9 –15 . A number of potential biases in these studies exist.…”

Section: The Definition Of Hnpccmentioning

confidence: 99%

Section: The Definition Of Hnpccmentioning

confidence: 99%