Hereditary Non‐polyposis Colorectal Cancer Syndrome

Moore, James W.; Cowled, Prue

doi:10.1046/j.1440-1622.1999.01469.x

Cited by 8 publications

(6 citation statements)

References 73 publications

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“…A colonoscopy every years from age 30 and gastroscopy every five years from age 50 have been suggested ( 114 ) . Guidelines for the management of colorectal cancer risk in MMR mutation carriers have been published ( 28,114–117 ) and reviewed ( 118 ) .…”

Section: Clinical Relevancementioning

confidence: 99%

The contribution of DNA mismatch repair gene defects to the burden of gynecological cancer

Drake¹,

Campbell²,

Porteous³

et al. 2003

Int J Gynecol Cancer

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Section: Clinical Relevancementioning

confidence: 99%

The contribution of DNA mismatch repair gene defects to the burden of gynecological cancer

Drake¹,

Campbell²,

Porteous³

et al. 2003

Int J Gynecol Cancer

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“…Individuals with hereditary nonpolyposis colon cancer, and families with familial polyposis coli have been identified to be at high risk of developing CRC (10,11). Specific aggressive screening guidelines exist for such patients (12).…”

Section: Risk Factorsmentioning

confidence: 99%

The Quebec Association of Gastroenterology Position Paper on Colorectal Cancer Screening - 2003

Jobin²,

Cousineau³

et al. 2004

Canadian Journal of Gastroenterology

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Colorectal cancer is a leading cause of death and the third most common cancer in Canada. Evidence suggests that screening can reduce mortality rates and the cost effectiveness of a program compares favourably with initiatives for breast and cervical cancer. The objectives of the Association des gastro-entérologues du Québec Task Force were to determine the need for a policy on screening for colorectal cancer in Quebec, to evaluate the testing methods available and to propose one or more of these alternatives as part of a formal screening program, if indicated. Fecal occult blood testing (FOBT), endoscopy (including sigmoidoscopy and colonoscopy), barium enema and virtual colonoscopy were considered. Although most clinical efficacy data are available for FOBT and sigmoidoscopy, there are limitations to programs based on these strategies. FOBT has a high false positive rate and a low detection yield, and even a combination of these strategies will miss 24% of cancers. Colonoscopy is the best strategy to both detect and remove polyps and to diagnose colorectal cancer, with double contrast barium enema also being a sensitive detection method. The Task Force recommended the establishment, in Quebec, of a screening program with five- to 10-yearly double contrast barium enema or 10-yearly colonoscopy for individuals aged 50 years or older at low risk. The program should include outcome monitoring, public and professional education to increase awareness and promote compliance, and central coordination with other provincial programs. The program should be evaluated; specific billing codes for screening for colorectal cancer would help facilitate this. Formal feasibility, effectiveness and cost-effectiveness studies in Quebec are now warranted.

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“…If a mutation is identified, regular surveillance is recommended, including colonoscopy every 1-3 years starting at age 25. [6][7][8] Internal Medicine Journal 2004; 34: 61-65 Spiros: Good questions, Martin! I think you're wasting your talents being a lawyer!…”

Section: [Guests Arrange Themselves Around the Table]mentioning

confidence: 99%

Genetic testing: a round table conversation. Part I

Komesaroff¹,

Greenberg²,

Piterman³

2004

Internal Medicine Journal

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ETHICS IN MEDICINEThe ethical dimension of medicine is diverse, complex and all-pervasive. Ethics lies at the heart of clinical practice: it defines what we do and how and why we do it . The processes of communication and dialogue about values are as fundamental to clinical medicine as are factual, scientific knowledge and rigorously defined processes of reasoning and analysis. Perhaps paradoxically, however, how to talk about ethics has always been a problem. While the scientific world has available to it a well developed, highly effective and tightly regulated literary culture this is not the case for ethics. Because ethical reflection and experience are not exhausted by formal logic and linear argument ethical discourse cannot always be encompassed by the conventions of scientific writing. This has been recognised traditionally in the humanities, where ethical issues have been explored using a variety of literary settings, especially through the medium of the novel. In medicine, ethical discussion has often sought to conform to the style of scientific writing and expression, and this has led to important insights. However, some key limitations have also emerged: in particular, it has been difficult to present in an effective manner diverse and contending points of view, to ensure the preservation of ambiguity, and to convey both the extent to which the ethical imagination is embedded within clinical practice and the complexity of the dynamic dialogues it inhabits.One of the tasks of ethics is clearly to find forms of expression appropriate to both its processes and its subject matter. The following essay, which seeks to show how ethical reflection often proceeds through dialogues representing multiple viewpoints, is an example of an attempt to extend the presentation of ethical issues in clinical medicine to include some of these features. The responses of readers will be welcomed, as will additional submissions on the subject of ethics that employ innovative literary forms.

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Hereditary Non‐polyposis Colorectal Cancer Syndrome

Cited by 8 publications

References 73 publications

The contribution of DNA mismatch repair gene defects to the burden of gynecological cancer

The contribution of DNA mismatch repair gene defects to the burden of gynecological cancer

The Quebec Association of Gastroenterology Position Paper on Colorectal Cancer Screening - 2003

Genetic testing: a round table conversation. Part I

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