Prevalence of hepatitis C virus infection and related risk factors among Iranian haemodialysis patients

Alavian, Seyed Moayed; Einollahi, Behzad; Hajarizadeh, Behzad; Siamak, Bakhtiari; Nafar, Mohsen; Sadegh, Ahrabi

doi:10.1046/j.1440-1797.2003.00166.x

Cited by 44 publications

(51 citation statements)

References 27 publications

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“…Two HCV genotypes were identified in these patients in Ahvaz city: subtypes 1a and 1b. Subtype 1a was predominant (60%) similar to the recent studies in different populations in the region (18,21). This finding is different from HCV genotypes distribution and the high frequency of genotype HCV 1a/1b plus HCV 4 and HCV 2/2a plus HCV 4in multi-transfused patients living in neighbouring countries, such as Bahrain and Saudi Arabia respectively, sharing sea boarder with Khuzestan province (4).…”

Section: Discussionsupporting

confidence: 73%

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Hepatitis B and C Infections and Different Genotypes of HCV Among Sickle Cell Anemia Patients in Ahvaz, South-Western Iran

Ghafourian-Boroujerdnia

Assarehzadegan

Zandian

2013

Jundishapur J Microbiol

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Background:Although it is life-saving, blood transfusion therapy has resulted in risk for transfusion-transmitted infections (TTIs) in the majority of sickle cell anemia being patients. Objectives: The current study aimed to determine the prevalence of HBV, HCV and different genotypes of HCV among sickle cell anemia (SCA) patients in Ahvaz city, South-western Iran. Materials and Methods: A cross-sectional study was conducted on 56 SCA patients who referred to the Hemoglobinopathy and Thalassemia research centre during January 2009 to February 2010. Patients` sera were tested for HBsAg and anti-HCV using ELISA and confirmed by PCR (HBV) and RT-PCR (HCV). HCV genotypes were determined with HCV genotype specific primers using HCV genotyping kit. Results:The overall prevalence rate of HBsAg and anti-HCV were 1.8% (95% CI: 0-5.26) and 12.5% (95% CI: 3.8 -21.1), respectively. Five of the anti-HCV patients (71.4%) were also HCV RNA positive. The predominant HCV genotype in the patients was 1a (60%), though genotype 1b was found in 40% of the subjects. Conclusions: It seems that stringent donor selection procedures reduce HCV infection in multi-transfused patients, but there is still serious risk for these patients.

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Section: Discussionsupporting

confidence: 73%

“…Recent studies of SCA patients show that the prevalence of anti-HCV varied (4.5 to 21%) (2,(11)(12)(13), which suggests that the geographical area may affect the potential risk of HCV in patients (17)(18)(19). Moreover, one of the most common causes of HCV transmission by transfusion is the occurrence of new infections in blood donors.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis B and C Infections and Different Genotypes of HCV Among Sickle Cell Anemia Patients in Ahvaz, South-Western Iran

Ghafourian-Boroujerdnia

Assarehzadegan

Zandian

2013

Jundishapur J Microbiol

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“…As reported in several studies, HCV infection is a significant health problem in dialysis units in our country with a high prevalence rate (13.2%) among this population [20] . It was reported that blood transfusion and duration of dialysis treatment are important risk factors for HCV infection in patients on haemodialysis [21,22] .…”

Section: Discussionsupporting

confidence: 52%

Seroepidemiology of hepatitis C and its risk factors in Khuzestan Province, South-West of Iran: A case-control study

Hajiani

Hashemi²,

Masjedizadeh³

et al. 2006

WJG

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extramarital sexual activities (2.4%), tattooing (3.6%) were found to be independent risk factors of being HCVpositive. No apparent risk factors could be demonstrated in 29 (11.2%) of the positive cases. CONCLUSION:Our data indicate that a history of transfusion and iv drug abuse and haemodialysis are important risk factors for HCV infection in our area and that more careful pretransfusion screening of blood for anti-HCV must be introduced in our blood banks. Improvements in certain lifestyle patterns, and customs in this area may be essential to prevent transmission of the infection. INTRODUCTIONHepatitis C virus (HCV) infection is responsible for considerable morbidity and mortality worldwide. HCV is a leading cause of liver failure and liver transplantation in adults. Identified risk factors for HCV infection include intravenous (IV) drug use, exposure to infected blood products, and intranasal drug use [1] . High-risk sexual activity [multiple sexual partners, history of sexually transmitted disease (STD)], tattooing, and skin piercing have also been suggested to be associated with increased risk for HCV [2] . In addition, mother-to-infant transmission has been demonstrated [3,4] , but the possibility of other transmission routes has not been thoroughly explored. With the use of RT-PCR or bDNA techniques, HCVRNA has been detected in many systemic fluids other than blood, including peritoneal fluids, seminal and vaginal secretion, urine, and feces. These observations, however, have not been confirmed by all investigators [5] . The possibility of HCV replication in the mosquito alimentary tract has recently been demonstrated, but the epidemiological importance of this has not yet been RAPID COMMUNICATION Seroepidemiology of hepatitis C and its risk factors in

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“…Recently the thalassaemia data bank has been reported that the prevalence of HCV infection in these patients is 16%. It has also reported that over 70% of thalassaemia patients in Iran are older than 10 years [29]. In Iran, the prevalence of anti-HCV in hemophiliac is from 15.65% to 76.7% in patients from various geographical regions [30].…”

Section: Discussionmentioning

confidence: 99%

Identification of HCV genotypes in HCV infected blood donors

Sharifi¹,

Shooshtari²,

Kermani³

2010

Indian J Microbiol

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HCV infection is a leading cause of chronic liver disease, including cirrhosis of the liver. There are at least six major genotypes and more than 50 subtypes of HCV. The prevalence and distribution of HCV genotypes depend on geographical location. The aim of this study was to identify and compare the HCV genotypes in HCV infected blood donors and patients. In this cross-sectional study, 167 serum samples from 103 blood donors and 64 patients with hepatitis C were investigated for HCV genotypes. HCV genotyping was carried out using type-specifi c primers from the core region of the viral genome. The highest frequency was for genotype 1a, with 53 and 34 (51.5% versus 53.1%) of subjects in blood donors and patients respectively. Genotype 3a and 1b were the other frequent genotypes with 4 and 16 (3.9% versus 25%) and 39 and 10 (37.9% versus 15.6%) subjects, respectively. There was not any statistical signifi cant association between the place of infection of the patients and genotype. The results of this study indicate that the distribution of genotypes in the two populations was similar. The dominant HCV genotypes between blood donors and patients were 1a, 3a and 1b respectively.

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Prevalence of hepatitis C virus infection and related risk factors among Iranian haemodialysis patients

Cited by 44 publications

References 27 publications

Hepatitis B and C Infections and Different Genotypes of HCV Among Sickle Cell Anemia Patients in Ahvaz, South-Western Iran

Hepatitis B and C Infections and Different Genotypes of HCV Among Sickle Cell Anemia Patients in Ahvaz, South-Western Iran

Seroepidemiology of hepatitis C and its risk factors in Khuzestan Province, South-West of Iran: A case-control study

Identification of HCV genotypes in HCV infected blood donors

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