Identification of HCV genotypes in HCV infected blood donors

Sharifi, Zohreh; Shooshtari, Mahmood Mahmoodian; Kermani, Fahimeh Rangbar

doi:10.1007/s12088-010-0059-0

Cited by 7 publications

(4 citation statements)

References 25 publications

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“…In the current study, based on the sequencing of a segment of NS5B in HCV genome, subtype 3a (61.32%) was the predominant subtype followed by 1a (29.25%) and 1b (9.43%). The results were in contrast with those of a study conducted on 96 Iranian blood donors in 2010, which showed that HCV subtype 1a was the most frequent subtype followed by 3a and 1b (14). In the current study, compared with the above mentioned study, a significant decrease in the prevalence of HCV genotypes 1a from 51.5% to 29.25% (P = 0.05) were observed.…”

Section: Discussioncontrasting

confidence: 99%

“…In the current study, no other HCV genotypes than 3a, 1a, and 1b were similar to those of the previous studies conducted on Iranian blood donors (14). The current preliminary study evaluated the association between HCV genotype and risk factors in Iranian blood donors.…”

Section: Discussionsupporting

confidence: 85%

“…However, in the current study, no association was observed between distinct HCV genotype and age, or HCV risk factors such as IVDA or blood transfusion. On the other hand, recent studies showed that HCV genotype 3a in IVD abusers and HCV genotype 1a in patients receiving blood or blood products were the most common genotypes (14,(49)(50)(51)(52). As shown in Table 2, genotype 3a was not the most frequent genotype just in IVDA donors.…”

Section: Discussionmentioning

confidence: 89%

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Distribution of Hepatitis C Virus Genotypes and Related Risk Factors Among Iranian Blood Donors: A Penalized Logistic Regression

Kermani

Amini-Kafiabad

Hosseini

et al. 2018

Jundishapur J Microbiol

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Background: The hepatitis C virus (HCV) is a blood born virus and the major cause of liver diseases worldwide. Distribution of HCV genotypes varies depending on geographical regions and routes of infection. Knowledge regarding the distribution of HCV genotypes and related risk factors plays an essential role in the control of HCV infection in the community. Objectives: The current study aimed at determining the current distribution of HCV genotypes and related risk factors among Iranian blood donors. Methods: In the current analytical, cross sectional study, 106 HCV-infected blood donors with detectable HCV RNA over the country were interviewed by trained physicians through a post-donation questionnaire on demographic, medical, and risk history from November 2015 to May 2017. The hepatitis C virus genotype was determined by sequencing of a segment of non-structural 5B region in HCV genome. Penalized logistic regression model was used for statistical analysis through STATA software. Results: Hepatitis C virus genotype was determined in all subjects, and the genotype 3a was the most frequent (65, 61.32%), followed by 1a (31, 29.25%), and 1b (10, 8.49%). Based on the multivariable analysis results, tattooing (adjusted odds ratio: 2.76; 95% confidence interval: 1.03-7.37) was associated with HCV genotype 3a. Conclusions: According to the results, it seems that changes in molecular epidemiology of HCV infection and replacement of HCV genotype 1a with 3a, characterized by an increase in genotype 3a and decrease in genotype 1a have occurred over the last decade among Iranian blood donors. Tattooing was an independent risk factor for HCV infection by genotype 3a.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 89%

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Distribution of Hepatitis C Virus Genotypes and Related Risk Factors Among Iranian Blood Donors: A Penalized Logistic Regression

Kermani

Amini-Kafiabad

Hosseini

et al. 2018

Jundishapur J Microbiol

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“…A similar study on Iranian patients revealed that 1a, 1b and 3a were predominant genotypes with an overall rate of 61.2%, 13.8%, and 25%, respectively (16). Sharifi et al showed that the prevalence of HCV genotypes in 103 blood donors and 64 patients are as following: The highest frequency was for genotype 1a, with 53 and 34 (51.5% versus 53.1%) of subjects in blood donors and patients respectively (17). Genotype 3a and 1b were the other frequent genotypes with 4 and 16 (3.9% versus 25%) and 39 and 10 (37.9% versus 15.6%) subjects, respectively.…”

Section: Introductionmentioning

confidence: 99%

Distribution of Hepatitis C Virus Genotypes Among Chronic Infected Injecting Drug Users in Tehran, Iran

Kermani¹,

Sharifi²,

Ferdowsian³

et al. 2013

Jundishapur J Microbiol

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Background: Hepatitis C virus (HCV) is the main cause of infection that has the potential to cause chronic liver disease. Injecting drug users (IDUs) have a key role in HCV transmission in Iran. Knowledge of the distribution of various genotypes is essential for successful future research and control strategies.Objectives: The aim of this study was to identify HCV genotypes among chronic infected injecting drug users (IDUs) in Tehran, Iran.Patients and Methods: In this cross sectional study, we investigated HCV genotypes among 36 plasma samples from HCV infected IDUs (35 male and 1female, mean age: 33.67, and age range 20-62 years), referred to Research Center of Iranian Blood Transfusion Organization(IBTO) in Tehran from December 2008 to March 2009.HCV Genotyping was performed using type-specific primers.Results: Genotypes 3a, 1a and 1b were found in 58.3 %, 25% and 16.7 % patients, respectively.Conclusions: Our study demonstrated the high prevalence of genotype 3a among injecting drug users, which is also found in Europe and United states

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Hepatitis C virus infection in Iran: A review of current prevalence and preventive strategies from a developing country

Tantuoyir,

Camara,

Sohrabi

et al. 2024

Journal of Clinical Virology Plus

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Identification of HCV genotypes in HCV infected blood donors

Cited by 7 publications

References 25 publications

Distribution of Hepatitis C Virus Genotypes and Related Risk Factors Among Iranian Blood Donors: A Penalized Logistic Regression

Distribution of Hepatitis C Virus Genotypes and Related Risk Factors Among Iranian Blood Donors: A Penalized Logistic Regression

Distribution of Hepatitis C Virus Genotypes Among Chronic Infected Injecting Drug Users in Tehran, Iran

Hepatitis C virus infection in Iran: A review of current prevalence and preventive strategies from a developing country

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