Distribution of Hepatitis C Virus Genotypes Among Chronic Infected Injecting Drug Users in Tehran, Iran

Kermani, Fahimeh Ranjbar; Sharifi, Zohreh; Ferdowsian, Fereshteh; Paz, Zahrah; Zamanian, Mahsa

doi:10.5812/jjm.5191

Cited by 5 publications

(10 citation statements)

References 20 publications

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“…However, in the current study, no association was observed between distinct HCV genotype and age, or HCV risk factors such as IVDA or blood transfusion. On the other hand, recent studies showed that HCV genotype 3a in IVD abusers and HCV genotype 1a in patients receiving blood or blood products were the most common genotypes (14,(49)(50)(51)(52). As shown in Table 2, genotype 3a was not the most frequent genotype just in IVDA donors.…”

Section: Discussionmentioning

confidence: 88%

Distribution of Hepatitis C Virus Genotypes and Related Risk Factors Among Iranian Blood Donors: A Penalized Logistic Regression

Kermani

Amini-Kafiabad

Hosseini

et al. 2018

Jundishapur J Microbiol

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Background: The hepatitis C virus (HCV) is a blood born virus and the major cause of liver diseases worldwide. Distribution of HCV genotypes varies depending on geographical regions and routes of infection. Knowledge regarding the distribution of HCV genotypes and related risk factors plays an essential role in the control of HCV infection in the community. Objectives: The current study aimed at determining the current distribution of HCV genotypes and related risk factors among Iranian blood donors. Methods: In the current analytical, cross sectional study, 106 HCV-infected blood donors with detectable HCV RNA over the country were interviewed by trained physicians through a post-donation questionnaire on demographic, medical, and risk history from November 2015 to May 2017. The hepatitis C virus genotype was determined by sequencing of a segment of non-structural 5B region in HCV genome. Penalized logistic regression model was used for statistical analysis through STATA software. Results: Hepatitis C virus genotype was determined in all subjects, and the genotype 3a was the most frequent (65, 61.32%), followed by 1a (31, 29.25%), and 1b (10, 8.49%). Based on the multivariable analysis results, tattooing (adjusted odds ratio: 2.76; 95% confidence interval: 1.03-7.37) was associated with HCV genotype 3a. Conclusions: According to the results, it seems that changes in molecular epidemiology of HCV infection and replacement of HCV genotype 1a with 3a, characterized by an increase in genotype 3a and decrease in genotype 1a have occurred over the last decade among Iranian blood donors. Tattooing was an independent risk factor for HCV infection by genotype 3a.

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Section: Discussionmentioning

confidence: 88%

Distribution of Hepatitis C Virus Genotypes and Related Risk Factors Among Iranian Blood Donors: A Penalized Logistic Regression

Kermani

Amini-Kafiabad

Hosseini

et al. 2018

Jundishapur J Microbiol

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“…The transmission of HCV occurs mainly through infected blood, blood products, and contaminated devices, such as syringes and needles. Today, intravenous drug use is an important route of HCV transmission ( 4 , 61 ). Precise data about the pattern of HCV genotypes and continuous monitoring of the genetic diversity of virus isolates, especially among high-risk individuals (hemophilia, thalassemia, hemodialysis, multiply transfused patients and intravenous drug use) is essential for understanding HCV epidemiology ( 33 ).…”

Section: Discussionmentioning

confidence: 99%

“…Prevalence of HCV among patients on hemodialysis was 5.5% to 55.9% in different cities of Iran, although this number for patients with hemophilia was 15.65 to 76.7% ( 3 ). The rate of HCV positivity among IVDUs was 52% in Tehran ( 4 ).…”

Section: Contextmentioning

confidence: 99%

“…Infection with genotype 1 may proceed rapidly to severe chronic disease, cirrhosis, and hepatocellular carcinoma. Studies have shown that subtype 3a is significantly associated with transmission through IVDUs in industrial countries ( 4 ). Therefore, before any treatment, the genotype of the virus must be determined to estimate the dose, duration and type of antiviral drugs, and the virological monitoring method ( 10 , 12 ).…”

Section: Contextmentioning

confidence: 99%

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Prevalence of Hepatitis C Virus Genotypes in Iranian Patients: a Systematic Review and Meta-Analysis

Khodabandehloo¹,

Roshani²

2014

Hepat Mon

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Context:Hepatitis C virus (HCV) is a global public health problem and a major etiology of chronic liver disease, which may develop into cirrhosis and hepatocellular carcinoma. Genotypes of HCV indicate the route of acquisition, the clinical outcome, response to treatment, prognosis and control strategies.Objectives:The aim of this study was to estimate the overall prevalence and trend of HCV genotypes or subtypes in IranData Sources:A literature review was done for papers reporting HCV genotypes in Iranian patients in PubMed, Magiran, IranMedex, Scientific Information Databank, and Google scholar databases.Study Selection:Data were selected according to inclusion and exclusion criteria.Data Extraction:Data were abstracted by two independent authors. Data were analyzed based on random-effects model using the Meta R. Pooled statistical software. Prevalence of HCV genotypes in cities and provinces of Iran with 95% confidence interval (CI) were calculated.Results:Fifty-three articles published between 1999 and 31 June 2014 including 22952 HCV infected individuals were included in the meta-analysis. Subtype 1a was predominant with a rate of 39% (95% CI: 34-44%); followed by subtype 3a, 32% (95% CI: 26-39%); subtype 1b, 13% (95% CI: 10-15%); genotype 4, 5.18% (95% CI: 3.27-7.5%); and genotype 2, 3.6% (95% CI: 1.6-8.3%). Untypeable HCV had a rate of 0.11% (95% CI: 0.07-0.16%).Conclusions:The most frequent subtypes of HCV in Iran were 1a, 3a and 1b, respectively. This frequency differed in various provinces of Iran and fluctuated with time. It is important to determine the distribution of HCV genotypes in different geographical areas and its trend with time for epidemiological and patients’ management purposes.

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“…I read with interest the published article by Ranjbar Kermani et al ( 1 ). Genotyping of hepatitis C virus (HCV) is important, which provides information about strain variation and characteristics of virus during the treatment and the therapy response rate ( 2 ).…”

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confidence: 99%

Hepatitis C Genotypes Distribution in Intravenous Drug Users in Tehran

Alavian

2015

Jundishapur J Microbiol

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Distribution of Hepatitis C Virus Genotypes Among Chronic Infected Injecting Drug Users in Tehran, Iran

Cited by 5 publications

References 20 publications

Distribution of Hepatitis C Virus Genotypes and Related Risk Factors Among Iranian Blood Donors: A Penalized Logistic Regression

Distribution of Hepatitis C Virus Genotypes and Related Risk Factors Among Iranian Blood Donors: A Penalized Logistic Regression

Prevalence of Hepatitis C Virus Genotypes in Iranian Patients: a Systematic Review and Meta-Analysis

Hepatitis C Genotypes Distribution in Intravenous Drug Users in Tehran

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