Prevalence of hepatitis C and G virus infection in chronic hemodialysis patients

Medina, Maria de; Ashby, M. H.; Schlüter, Volker; Hill, Mary Ann; Leclerq, B.; Pennell, JP; Jeffers, L; Reddy, K. Rajender; Er, Schiff; Heß, Georg; Perez, Gonzalo

doi:10.1053/ajkd.1998.v31.pm9469491

Cited by 35 publications

(38 citation statements)

References 5 publications

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“…Several authors demonstrated a high prevalence of HGV in hemodialysis patients with a wide range between different countries [7]. Our figure of 17.6% is similar to that observed in most countries, including United States [10], Belgium [11], Italy [12], Spain [13], and Austria [14,15]. However, lower and higher prevalences have been reported in other countries: 3% to 10% in Japan and Germany [5,[16][17][18] and 55% to 57% in Indonesia and France [19,20].…”

Section: Discussionsupporting

confidence: 87%

Hepatitis G Virus Infection in Hemodialysis Patients and Its Relationship with Hepatitis C Virus Infection

Fernández¹,

Valtuille²,

Hidalgo³

et al. 2000

Am J Nephrol

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Our aim was to study the characteristics of hepatitis G virus (HGV) infection in hemodialysis (HD) patients. We evaluated 108 patients from two different units (A: 67 patients; B: 41 patients). HGV RNA and HCV RNA were detected by PCR. Nineteen patients (17.6%) were HGV RNA positive (20.9% in unit A and 12.2% in unit B (NS)). HCV RNA was positive in 19 patients (17.6%) (28.4% in unit A and 0 in unit B (p < 0.01)). Eight patients were HGV RNA and HCV RNA positive (group I), 11 HGV RNA positive (group II), 11 HCV RNA positive (group III), and 78 negative for both viruses (group IV). Time on HD was 51.3 +/- 37.0 months for group I, 36.0 +/- 27.9 months for group II, 63.5 +/- 40.2 months for group III, and 26.4 +/- 27.1 months for group IV (p < 0.01 for I and III). Seven patients (87.5%) from group I, 9 (81.8%) from group II, 10 (90.9%) from group III, and 44 (56.4%) from group IV had a history of transfusion (p < 0.03 for I, II and III). Two patients (25%) from group I, none from group II, 5 (45.4%) from group III, and 6 (7.7%) from group IV had chronic ALAT elevation (p < 0.01 for I and III). We conclude that HGV infection was frequent in our HD patients, related to transfusions and independent of HCV prevalence, and that HGV infection itself was not a cause of ALAT elevation suggesting chronic hepatitis.

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Section: Discussionsupporting

confidence: 87%

Hepatitis G Virus Infection in Hemodialysis Patients and Its Relationship with Hepatitis C Virus Infection

Fernández¹,

Valtuille²,

Hidalgo³

et al. 2000

Am J Nephrol

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“…The prevalence of HGV infection in our haemodialysis population (15.4%) is lower than reported by other authors in our geographic area [19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29]. Methodological factors in HGV RNA detection do not explain these discrepancies, since we also amplified both 5′-UTR and NS3 regions.…”

Section: Discussioncontrasting

confidence: 74%

“…The lower percentages of polytransfused patients among our cases (29.5%, 23 out of 78 haemodialysis patients, and 17.2%, 5 out of 29 peritoneal dialysis patients) could explain the low prevalence of HGV infection in our dialysis population when compared with findings reported by other authors who indicate a higher HGV prevalence [19, 21, 23]. Moreover, because of the strong association between HCV and HGV, the screening of blood donors for HCV could have also reduced the risk of infection with HGV after 1990, modifying the incidence of HCV-HGV coinfection in polytransfused patients [23].…”

Section: Discussioncontrasting

confidence: 60%

“…Prevalence studies indicate that the percentage of HGV ranges from 1.6% among volunteer blood donors to more than 20% among polytransfused patients or drug abusers [12, 13, 14, 15, 16, 17]. The epidemiological data available so far show a significant discrepancy of HGV infection among haemodialysis patients [18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29]. In fact, the prevalence ranges from 3.1% reported by Japanese authors [18]to 57.5% reported by French authors [19].…”

Section: Introductionmentioning

confidence: 99%

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Hepatitis G Virus Infection in Haemodialysis and in Peritoneal Dialysis Patients

Campo

Sinelli²,

Brizzolara³

et al. 1999

Nephron

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The aim of this study was to detect hepatitis G virus RNA (HGV RNA) and antibodies against the virus envelope protein E2 (anti-E2) in 107 patients either on maintenance haemodialysis (n = 78) or peritoneal dialysis (n = 29) to evaluate the prevalence of HGV infection and to establish its role in liver disease. The total prevalence of HGV infection was of 15.4% among haemodialysis patients, whereas it was 10.3% among peritoneal dialysis patients. HGV RNA was detected in 2 haemodialysis patients (2.6%) and in 3 peritoneal dialysis patients (10.3%). Anti-E2 was found in 10 haemodialysis patients (7.8%), whilst all peritoneal dialysis patients resulted negative. In only 1 patient the alanine aminotransferase level was elevated. This patient underwent liver biopsy that did not reveal evidence of chronic hepatitis. The lower HGV prevalence in haemodialysis patients, when compared with data reported by other European authors, should be related to the lower rate of polytransfused patients in our series (29.5%). Multiple blood transfusions should be considered as the main factor to explain the different prevalence of HGV infection among various European dialysis centres. Detection of both antibody and viraemia is important to establish the real rate of the infection.

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“…As the number of patients studied was small, further investigations are necessary to provide more information on the epidemiology of GBV-C/HGV infection among patients on peritoneal dialysis treatment. Regarding hemodialysis patients, GBV-C/HGV RNA prevalence rates range from 3.1% to 15% in Japan (Masuko et al 1996, Shibuya et al 1998, from 11.5% to 20% in the US (Bastani et al 1998, Medina et al 1998 and from 6% to 57.5% in Europe (de Lamballerie et al 1996, Fabrizi et al 1997. It has also been reported a high rate (55%) in Indonesia .…”

Section: Discussionmentioning

confidence: 99%

GB virus C/hepatitis G virus infection in dialysis patients and kidney transplant recipients in central Brazil

Filho

Carneiro

Teles

et al. 2004

Mem. Inst. Oswaldo Cruz

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Prevalence of hepatitis C and G virus infection in chronic hemodialysis patients

Cited by 35 publications

References 5 publications

Hepatitis G Virus Infection in Hemodialysis Patients and Its Relationship with Hepatitis C Virus Infection

Hepatitis G Virus Infection in Hemodialysis Patients and Its Relationship with Hepatitis C Virus Infection

Hepatitis G Virus Infection in Haemodialysis and in Peritoneal Dialysis Patients

GB virus C/hepatitis G virus infection in dialysis patients and kidney transplant recipients in central Brazil

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