GB virus C/hepatitis G virus infection in dialysis patients and kidney transplant recipients in central Brazil

Filho, Ramon Ramos; Carneiro, Megmar Aparecida dos Santos; Teles, Sheila Araújo; Dias, Miguel Joaquim; Cardoso, Divina D. P.; Lampe, Elisabeth; Yoshida, Clara Fumiko Tachibana; Martins, Regina Maria Bringel

doi:10.1590/s0074-02762004000600019

Cited by 18 publications

(3 citation statements)

References 34 publications

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“…The prevalence of HPgV‐1 viremia among renal transplant patients was 36.1%, much higher than the frequency found in a previous Brazilian study, where HPgV‐1 RNA was detected in 16.7% among kidney recipients 21 . This discrepancy might be explained by the low number of transplant patients evaluated in the former study (n = 12), different locality of the study population, and/or methodology used to perform the molecular tests.…”

Section: Discussioncontrasting

confidence: 62%

“…In Brazil, few studies have evaluated the circulating genotypes of HPgV‐1 and the main studied population was blood donors and HIV‐infected individuals. Genotypes 1, 2, and 3 were commonly found, but strains from genotype 2 and its subtypes (2a and 2b) constituted the majority and most widely spread in Brazil, ranging from 72% to 98% of sequenced samples 14,21,32‐38 . Our results demonstrate the high prevalence of genotype 2 among kidney recipients in Rio de Janeiro, identified in 80.9% of cases; followed by 9.5% of genotype 3% and 4.8% of genotypes 1 and 5 each.…”

Section: Discussionmentioning

confidence: 61%

“…In the present study, we determined the prevalence and genotypic characteristics of HPgV‐1 in kidney transplant recipients. Until now, although HPgV‐1 has been considered a nonpathogenic agent, its activity reducing immune system activation has been investigated 17,18 and how this mechanism could impact organ transplantation outcome is still poorly understood 19‐21 …”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Human pegivirus‐1 infection in kidney transplant recipients: A single‐center experience

Savassi‐Ribas

Pereira

Horta

et al. 2020

Journal of Medical Virology

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Kidney transplantation is the treatment of choice for patients with end‐stage renal disease. In the posttransplant period, the induced immunosuppression leads to an increased risk of developing infectious diseases, a leading cause of death after kidney transplantation. Human pegivirus‐1 (HPgV‐1) is considered a nonpathogenic human virus and is highly frequent in individuals parenterally exposed, however, its impact on kidney transplantation outcome is poorly understood. Given the scarcity of epidemiological data for this infection on organ recipients in Brazil, we conducted a study in a single center for kidney transplantation in Rio de Janeiro, aiming to determine HPgV‐1 prevalence and genotypic distribution. Serum samples from 61 renal recipients, followed up for the first year after transplantation, were evaluated for viral RNA and genotypes were determined by sequencing of the 5′‐untranslated region. HPgV‐1 RNA was detected in 36.1% (22/61) of patients. Genotype 2 was the most commonly found (80.9%), followed by genotypes 3 (9.5%), 1, and 5, in 4.8% each. Statistical comparisons did not reveal any significant impact of HPgV‐1 in patient outcome. Further epidemiologic studies are needed to understand if immunosuppression may interfere in HPgV‐1 persistence rates and if viremia might impact graft dysfunction rates in kidney recipients.

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Section: Discussioncontrasting

confidence: 62%

Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Human pegivirus‐1 infection in kidney transplant recipients: A single‐center experience

Savassi‐Ribas

Pereira

Horta

et al. 2020

Journal of Medical Virology

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GB virus type C infection in hemodialysis patients considering co‐infection with hepatitis C virus

Hosseini-Moghaddam

Keyvani

Samadi

et al. 2008

Journal of Medical Virology

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GB virus type C is a well-known viral agent with capability of infecting patients undergoing hemodialysis. Liver enzyme levels in infected individuals have been reported to remain within the normal range. Simultaneous infection of GBV-C and other viral agents may occur due to common routes of transmission. A total of 104 hemodialysis patients living in Tehran were included in this case-control study (53 patients with HCV infection, group I; and 51 with no HCV infection, group II). Diagnosis was made by detection Anti-E(2) protein using ELISA and HCV-RNA using RT-PCR. History of HBV-infection, organ transplantation, depression, malignancies, chemotherapy, diabetes mellitus, thyroid disorders and chronic cutaneous disorders were considered. Patients were evaluated for high- risk behaviors such as intravenous drug injection, addiction or substance abuse. A total of 14 patients (13.6%) were GBV-C-infected. Four of them were co-infected with HCV. All patients with GBV-C infection had viral genotype 2. Thirteen patients (12%) had a history of multiple blood transfusions. Mean (+/-SD) age of GBV-C-infected patients was 48.7+/-13.8 years. Among GBV-C infected patients, three patients had a history of organ transplantation and three had a co-morbidity of diabetes mellitus. This study as the first case-control study to evaluate the association between GBV-C and HCV infection, to our knowledge, shows hemodialysis patients living in Tehran are infected with GBV-C with intermediate level of frequency. The association of GBV-C transmission with other viral blood-borne agents might be necessary.

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Emerging viral diseases in kidney transplant recipients

Moal

Zandotti²,

Colson

2012

Reviews in Medical Virology

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Viruses are the most important cause of infections and a major source of mortality in Kidney Transplant Recipients (KTRs). These patients may acquire viral infections through exogenous routes including community exposure, donor organs, and blood products or by endogenous reactivation of latent viruses. Beside major opportunistic infections due to CMV and EBV and viral hepatitis B and C, several viral diseases have recently emerged in KTRs. New medical practices or technologies, implementation of new diagnostic tools, and improved medical information have contributed to the emergence of these viral diseases in this special population. The purpose of this review is to summarize the current knowledge on emerging viral diseases and newly discovered viruses in KTRs over the last two decades. We identified viruses in the field of KT that had shown the greatest increase in numbers of citations in the NCBI PubMed database. BKV was the most cited in the literature and linked to an emerging disease that represents a great clinical concern in KTRs. HHV-8, PVB19, WNV, JCV, H1N1 influenza virus A, HEV, and GB virus were the main other emerging viruses. Excluding HHV8, newly discovered viruses have been infrequently linked to clinical diseases in KTRs. Nonetheless, pathogenicity can emerge long after the discovery of the causative agent, as has been the case for BKV. Overall, antiviral treatments are very limited, and reducing immunosuppressive therapy remains the cornerstone of management.

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GB virus C/hepatitis G virus infection in dialysis patients and kidney transplant recipients in central Brazil

Abstract: In order to investigate the prevalence of GB virus C (GBV-C)/hepatitis G virus (HGV) infection in dialysis

Cited by 18 publications

References 34 publications

Human pegivirus‐1 infection in kidney transplant recipients: A single‐center experience

Human pegivirus‐1 infection in kidney transplant recipients: A single‐center experience

GB virus type C infection in hemodialysis patients considering co‐infection with hepatitis C virus

Emerging viral diseases in kidney transplant recipients

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