Prevalence of hepatitis B virus and hepatitis C virus in patients with human immunodeficiency virus infection in central China

Chen, Xi; He, Jianmei; Ding, Lisha; Zhang, Guoqiang; Zou, Xiaobai; Zheng, Jianming

doi:10.1007/s00705-013-1681-z

Cited by 33 publications

(40 citation statements)

References 36 publications

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“…In this study, we found that the positive rate of HBsAg for HIV-infected patients in Shaanxi Province was 11.7%, which was higher than the general population in either China or Shaanxi Province. A number of domestic studies have shown that the positive rate of HBsAg in the HIV-infected patients was higher than that of the general population, and it ranged from 13.1% to 19.4% [30][31][32][33]. However, on the contrary, some studies have reported that in HIV-infected patients, the HBsAg positive rate was slightly lower than that of the national general population.…”

Section: Discussionmentioning

confidence: 95%

“…In our study, the rate of anti-HCV was 11.1% among HIV-infected patients in Shaanxi Province, which was also higher than in the general Chinese population, and 14-fold higher than in Shaanxi Province. Other studies have found both lower [35] and higher [32] HCV prevalences in HIV-positive patients, ranging from 2.2% to 62.4%. Pelton et al [57] found that 2357 cases of HIV/AIDS patients in Xinjiang had an anti-HCV positive rate of 38.0%.…”

Section: Discussionmentioning

confidence: 99%

“…Pelton et al [57] found that 2357 cases of HIV/AIDS patients in Xinjiang had an anti-HCV positive rate of 38.0%. Chen et al [32] found that the prevalence of anti-HCV was 62.4% among 978 HIV-infected individuals from Hunan Province, while Li et al [35] found that the anti-HCV positive rate was only 2.2% in 1314 HIV/AIDS patients under anti-viral treatment in You'an Hospital. The results above were quite different from that in our study.…”

Section: Discussionmentioning

confidence: 99%

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Epidemiological Features and Risk Factors for Acquiring Hepatitis B, Hepatitis C, and Syphilis in HIV-Infected Patients in Shaanxi Province, Northwest China

Zhang¹,

Ren²,

Chang³

2020

IJERPH

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Human immunodeficiency virus (HIV)-infected patients are at a higher risk for co-infection with Hepatitis B virus (HBV), Hepatitis C virus (HCV), and Treponema pallidum (TP; the agent causing syphilis) than the general population. The prevalence of HBV, HCV, and syphilis has geographic differences and varies from region to region among HIV-positive individuals. A retrospective study was carried out on HIV-positive individuals between June 2011 and June 2016 in Shaanxi Province. Univariate and multivariate logistic regression analyses using stepwise regression analysis regarding risk factors for HIV-HBV, HIV-HCV, and HIV-syphilis co-infection. HBV-HCV, HCV-syphilis, HBV-syphilis, and HBV-HCV-syphilis co-infection rates were 1.7%, 2.2%, 2.6%, and 0.1%, respectively. The rate of ineffective hepatitis B vaccine immunization was as high as 30.2% among HIV-positive individuals. Ethnicity (OR = 31.030, 95% CI: 11.643-82.694) and HIV transmission routes (OR = 134.024, 95% CI: 14.328-1253.653) were the risk factors for HCV infection in HIV-positive individuals. Among the HIV-positive individuals with the antibodies of TP, the rate of homosexual transmission was also higher, but heterosexual transmission was lower (OR = 0.549 95% CI: 0.382-0.789) The HIV-infected patients in Shaanxi Province had the characteristics of low active detection rate and late diagnosis. The high rate of ineffective vaccination against HBV suggests a need for improved vaccination services.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Epidemiological Features and Risk Factors for Acquiring Hepatitis B, Hepatitis C, and Syphilis in HIV-Infected Patients in Shaanxi Province, Northwest China

Zhang¹,

Ren²,

Chang³

2020

IJERPH

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“…In addition, HCV infection shares the same transmission routes with HIV infection, which had been already observed cluster of disease in studies [12,13]. Especially for the intravenous drug users (IDUs), the prevalence of co-infection of HIV and HCV are high [14], and the HIV epidemics have association with geographic factors [15].…”

Section: Introductionmentioning

confidence: 91%

Spatial Analysis on Hepatitis C Virus Infection in Mainland China: From 2005 to 2011

Wang¹,

Xing

Chen³

et al. 2014

PLoS ONE

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BackgroundThe burden of Hepatitis C virus (HCV) has become more and more considerable in China. A macroscopic spatial analysis of HCV infection that can provide scientific information for further intervention and disease control is lacking.MethodsAll geo-referenced HCV cases that had been recorded by the China Information System for Disease Control and Prevention (CISDCP) during 2005–2011 were included in the study. In order to learn about the changes of demographic characteristics and geographic distribution, trend test and spatial analysis were conducted to reflect the changing pattern of HCV infection.ResultsOver 770,000 identified HCV infection cases had specific geographic information during the study period (2005–2011). Ratios of gender (Male/Female, Z-value = −18.53, P<0.001), age group (≤30 years old/≥31 years old, Z-value = −51.03, P<0.001) and diagnosis type (Clinical diagnosis/Laboratory diagnosis, Z-value = −130.47, P<0.001) declined. HCV infection was not distributed randomly. Provinces Henan, Guangdong, Guangxi, Xinjiang, and Jilin reported more than 40,000 HCV infections during 2005 to 2011, accounting for 43.91% of all cases. The strength of cluster of disease was increasing in China during the study period. Overall, 11 provinces had once been detected as hotspots during 7 years, most of which were located in the central or border parts of China. Tibet, Qinghai, Jiangxi were the regions that had coldspots.ConclusionsThe number of clustering of HCV infection among older adults increased in recent years. Specific interventions and prevention programs targeting at main HCV epidemic areas are urgently in need in mainland China.

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“…A cross‐sectional study showed 9.5% HIV‐HBV and 8.3% HIV‐HCV co‐infection rates in China, with the highest HIV‐HBV prevalence (14.5%) in Southeastern China and the highest HIV‐HCV prevalence in the Central region (28.2%), indicating that HBV and HCV prevalence is high in HIV‐positive Chinese population and differs by geographic region [Xie et al, ]. In central China, the rates of HIV mono‐infection, HBV/HIV dual infection, HCV/HIV dual infection, and HBV/HCV/HIV triple infection were 30.4%, 7.2%, 50.2%, and 12.2%, respectively [Chen et al, ]. Among injecting drug users in China, the infection rates were 0.3–20.1% for HIV/HBV and 15–31.8% for HIV/HCV [Zhou et al, , ], while in blood donors, the prevalence of HIV‐HCV and HIV‐HBV co‐infection was 41.83–85% and 2.5–12.49% in China [Dong et al, ; Yan et al, ].…”

Section: Introductionmentioning

confidence: 99%

Epidemiological profile and risk factors of HIV and HBV/HCV co‐infection in Fujian Province, southeastern China

Yan

Yang

et al. 2016

Journal of Medical Virology

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This study aimed to investigate the epidemiological features of HIV-infected subjects co-infected with HBV/HCV in Fujian Province, southeastern China, and identify the risk factors. Blood samples were collected from 2,028 HIV antibody-positive subjects in Fujian Province. Serum HBsAg and anti-HCV antibody were detected, and CD4 T cell count was measured. Of the 2,028 subjects, the prevalence of HIV-HBV, HIV-HCV, and HIV-HBV-HCV co-infections was 16.22%, 3.7%, and 0.79%, respectively. Man (OR = 1.912, 95% CI: 1.371-2.667), key population (OR = 0.756, 95% CI: 0.57-0.976) and detainee (OR = 0.486, 95% CI: 0.259-0.909) were risk factors of HIV-HBV co-infection, and man (OR = 2.227, 95% CI: 1.096-4.525), minority (OR = 5.04, 95% CI: 1.696-14.98), junior high school or lower education (OR = 2.32, 95% CI: 1.071-5.025), intravenous drug use (OR = 38.46, 95% CI: 11.46-129.11) and detainee (OR = 5.687, 95% CI: 2.44-13.25) were risk factors of HIV-HCV co-infection. In addition, a lower mean CD4 T cell count was measured in HIV/HBV and HIV/HCV co-infected subjects than in HIV-infected subjects among the untreated individuals, while in the treated populations, a higher mean CD4 T cell count was detected in HIV/HBV and HIV/HCV co-infected subjects than in HIV-infected subjects. HIV co-infection with HBV or HCV, notably HIV-HBV co-infection, is widespread in southeastern China. Hepatitis virus screening should be included in monitoring of HIV infection, and HIV and hepatitis virus co-infection should be considered during the development of HIV antiretroviral therapy scheme. J. Med. Virol. 89:443-449, 2017. © 2016 Wiley Periodicals, Inc.

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Prevalence of hepatitis B virus and hepatitis C virus in patients with human immunodeficiency virus infection in central China

Cited by 33 publications

References 36 publications

Epidemiological Features and Risk Factors for Acquiring Hepatitis B, Hepatitis C, and Syphilis in HIV-Infected Patients in Shaanxi Province, Northwest China

Epidemiological Features and Risk Factors for Acquiring Hepatitis B, Hepatitis C, and Syphilis in HIV-Infected Patients in Shaanxi Province, Northwest China

Spatial Analysis on Hepatitis C Virus Infection in Mainland China: From 2005 to 2011

Epidemiological profile and risk factors of HIV and HBV/HCV co‐infection in Fujian Province, southeastern China

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