Epidemiological profile and risk factors of HIV and HBV/HCV co‐infection in Fujian Province, southeastern China

Abstract

This study aimed to investigate the epidemiological features of HIV-infected subjects co-infected with HBV/HCV in Fujian Province, southeastern China, and identify the risk factors. Blood samples were collected from 2,028 HIV antibody-positive subjects in Fujian Province. Serum HBsAg and anti-HCV antibody were detected, and CD4 T cell count was measured. Of the 2,028 subjects, the prevalence of HIV-HBV, HIV-HCV, and HIV-HBV-HCV co-infections was 16.22%, 3.7%, and 0.79%, respectively. Man (OR = 1.912, 95% CI: 1.371-2.667), key population (OR = 0.756, 95% CI: 0.57-0.976) and detainee (OR = 0.486, 95% CI: 0.259-0.909) were risk factors of HIV-HBV co-infection, and man (OR = 2.227, 95% CI: 1.096-4.525), minority (OR = 5.04, 95% CI: 1.696-14.98), junior high school or lower education (OR = 2.32, 95% CI: 1.071-5.025), intravenous drug use (OR = 38.46, 95% CI: 11.46-129.11) and detainee (OR = 5.687, 95% CI: 2.44-13.25) were risk factors of HIV-HCV co-infection. In addition, a lower mean CD4 T cell count was measured in HIV/HBV and HIV/HCV co-infected subjects than in HIV-infected subjects among the untreated individuals, while in the treated populations, a higher mean CD4 T cell count was detected in HIV/HBV and HIV/HCV co-infected subjects than in HIV-infected subjects. HIV co-infection with HBV or HCV, notably HIV-HBV co-infection, is widespread in southeastern China. Hepatitis virus screening should be included in monitoring of HIV infection, and HIV and hepatitis virus co-infection should be considered during the development of HIV antiretroviral therapy scheme. J. Med. Virol. 89:443-449, 2017. © 2016 Wiley Periodicals, Inc.

Epidemiological Features and Risk Factors for Acquiring Hepatitis B, Hepatitis C, and Syphilis in HIV-Infected Patients in Shaanxi Province, Northwest China

“…In this study, we found that the positive rate of HBsAg for HIV-infected patients in Shaanxi Province was 11.7%, which was higher than the general population in either China or Shaanxi Province. A number of domestic studies have shown that the positive rate of HBsAg in the HIV-infected patients was higher than that of the general population, and it ranged from 13.1% to 19.4% [30][31][32][33]. However, on the contrary, some studies have reported that in HIV-infected patients, the HBsAg positive rate was slightly lower than that of the national general population.…”

HBV, HCV, and HBV/HCV co‐infection among HIV‐positive patients in Hunan province, China: Regimen selection, hepatotoxicity, and antiretroviral therapy outcome

“…One study in south-eastern China showed that the prevalence of HBV, HCV, and HBV/HCV co-infection among PLHIV was 16.22%, 3.7%, and 0.79%, respectively. 10 These rates were generally higher than other developed countries. 11 Although the widespread use of ART for HIV has significantly reduced the mortality and improved the life quality among PLHIV, 12 treatment of HIV in PLHIV with hepatitis co-infection is complicated as ART may increase the risk of hepatotoxicity and associated mortality.…”

Epidemiological features and risk factors for acquiring Hepatitis B, Hepatitis C and syphilis in HIV-infected patients in Shaanxi Province, northwest China

“…In this study, we found that the positive rate of HBsAg for HIV-infected patients in Shaanxi Province was 11.0%, which was higher than the general population in whether China or Shaanxi Province. A number of domestic studies have shown that the positive rate of HBsAg in the 10 HIV-infected patients was higher than that of the general population, and it ranged from 13.1% to 19.4% [30][31][32][33]. However, on the contrary, some studies have reported that in HIV-infected patients, the HBsAg positive rate was slightly lower than that of the national general population.…”

“…Moreover, studies reported that the rates of co-infection with HBV, HCV, and syphilis had geographic differences and varied from region to region, and based on study population and risk factors for virus acquisition [27][28][29]. In China, studies showed that among HIV-infected individuals, approximately 5.3%-19.4% were positive for HBV [30][31][32][33][34]; as assessed by the hepatitis B surface antigen (HBsAg) test, while HCV positivity (detected by the anti-HCV antibody test) varied from 2.2% to 62.4% [30][31][32][33][34][35]. However, the epidemiological and clinical profiles of HBV, HCV, and syphilis infection among HIV-infected patients remain unknown in many regions of China.…”