Prevalence of Helicobacter pyloriinfection and associated factors among adults in Southern Brazil: a population-based cross-sectional study

Santos, Iná S.; Boccio, José; Santos, A. Simoes; Valle, Neiva C. J.; Halal, Camila S.; Bachilli, Marta Colvara; Lopes, Ricardo D

doi:10.1186/1471-2458-5-118

Cited by 59 publications

(61 citation statements)

References 29 publications

(31 reference statements)

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“…In populations with precarious SES, resident in urban and rural areas, the prevalence of infection may reach 70% of children at 5 years of age, reaching over 80% of individuals after the age of 20. Moreover, the improvement in the population's living conditions, characterized by higher household income, higher level of education and adequate health services, provides an impact on the prevalence of H pylori infection, with a drop in the prevalence of H pylori infection (1,32,103,108,138,170,183,202,212) .…”

Section: Group 5 Epidemiology Of Infection and Proposals For Action mentioning

confidence: 99%

3rd BRAZILIAN CONSENSUS ON Helicobacter pylori

Coelho

Maguinilk

Zaterka³

et al. 2013

Arq. Gastroenterol.

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Significant progress has been obtained since the Second Brazilian Consensus Conference on Helicobacter pylori Infection held in 2004, in São Paulo, SP, Brazil, and justify a third meeting to establish updated guidelines on the current management of H. pylori infection. The Third Brazilian Consensus Conference on H pylori Infection was organized by the Brazilian Nucleus for the Study of Helicobacter, a Department of the Brazilian Federation of Gastroenterology and took place on April 12-15, 2011, in Bento Gonçalves, RS, Brazil. Thirty-one delegates coming from the five Brazilian regions and one international guest, including gastroenterologists, pathologists, epidemiologists, and pediatricians undertook the meeting. The participants were allocated in one of the five main topics of the meeting: H pylori, functional dyspepsia and diagnosis; H pylori and gastric cancer; H pylori and other associated disorders; H pylori treatment and retreatment; and, epidemiology of H pylori infection in Brazil. The results of each subgroup were submitted to a final consensus voting to all participants. Relevant data were presented, and the quality of evidence, strength of recommendation, and level of consensus were graded. Seventy per cent and more votes were considered as acceptance for the final statement. This article presents the main recommendations and conclusions to guide Brazilian doctors involved in the management of H pylori infection.

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Section: Group 5 Epidemiology Of Infection and Proposals For Action mentioning

confidence: 99%

3rd BRAZILIAN CONSENSUS ON Helicobacter pylori

Coelho

Maguinilk

Zaterka³

et al. 2013

Arq. Gastroenterol.

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“…In Brazil, the overall prevalence of H. pylori is high when compared to that of developed countries, although the rates found vary according to the geographical region studied. In the south of Brazil, the rate of H. pylori prevalence in adults is ~63%, while in the poorest regions such as the northeast and mid-west it is ~90% [27][28][29] . Regarding the State of Minas Gerais, where the population evaluated in the present study lives, rates of H. pylori infection ranging from 62% to 86% have been reported among adults 17,30 .…”

Section: Conflict Of Interest Financial Support Referencesmentioning

confidence: 99%

Seroprevalence of Helicobacter pylori infection in chagasic and nonchagasic patients from the same geographical region of Brazil

Fonseca

Queiroz

Rocha

et al. 2012

Rev. Soc. Bras. Med. Trop.

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Introduction:In this study, we evaluated the seroprevalence of Helicobacter pylori infection among chagasic and non-chagasic subjects as well as among the subgroups of chagasic patients with the indeterminate, cardiac, digestive, and cardiodigestive clinical forms. Methods: The evaluated subjects were from the Triângulo Mineiro region, Minas Gerais, Brazil. Chagasic patients showed positive reactions to the conventional serological tests used and were classified according to the clinical form of their disease. Immunoglobulin G antibodies specific to H. pylori were measured using a commercial enzyme-linked immunosorbent assay kit. Results:The overall H. pylori prevalence was 77.1% (239/310) in chagasic and 69.1% (168/243) in non-chagasic patients. This difference was statistically significant even after adjustment for age and sex (odds ratio = 1.57; 95% confidence interval, 1.02-2.42; p = 0.04) in multivariate analysis. The prevalence of infection increased with age in the non-chagasic group (p = 0.007, χ 2 for trend), but not in the chagasic group (p = 0.15, χ 2 for trend). H. pylori infection was not associated with digestive or other clinical forms of Chagas disease (p = 0.27).Conclusions: Our findings demonstrate that chagasic patients have a higher prevalence of H. pylori compared to non-chagasic subjects; a similar prevalence was found among the diverse clinical forms of the disease. The factors contributing to the frequent co-infection with H. pylori and Trypanosoma cruzi as well as its effects on the clinical outcome deserve further study. Keywords: Helicobacter pylori. Chagas disease. Chronic Chagas disease clinical forms. Co-infection. RESUMO Introdução:No presente estudo, foi comparada a soroprevalência da infecção por Helicobacter pylori entre os indivíduos chagásicos e não-chagásicos, bem como entre subgrupos de chagásicos com as formas clínicas indeterminada, cardíaca, digestiva e cardiodigestiva. Métodos: Os indivíduos avaliados eram provenientes da região do Triângulo Mineiro, Minas Gerais, Brasil. Foram realizados testes sorológicos convencionais para diagnóstico da infecção pelo T. cruzi e os chagásicos foram classificados de acordo com a forma clínica. O diagnóstico de infecção por H. pylori foi estabelecido pela detecção de anticorpos IgG específicos utilizando-se um kit comercial de ELISA. Resultados: A prevalência da infecção por H. pylori foi 77,1% (239/310) no grupo de pacientes chagásicos e 69,1% (168/243) no grupo de não-chagásicos. Esta diferença foi estatisticamente significativa mesmo após ajuste para idade e sexo (OR = 1,57; 95% CI, 1,02-2,42; p = 0,04) na análise multivariada. A prevalência da infecção aumentou de acordo com a idade no grupo não-chagásicos (p = 0,007, χ 2 for trend) mas este aumento não foi observado no grupo dos chagásicos (p = 0,15, χ 2 for trend). Não houve associação da infecção por H. pylori com a forma digestiva ou com qualquer outra forma clínica da doença de Chagas (p = 0,27). Conclusões: Foi demonstrado que pacientes chagásicos apresentam maior pre...

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“…This would require a sample size of 125 patients in each group (H. pylori-positive and H. pylori-negative according to the gold standard); with an additional 10% for losses and refusals, total sample size would have to be of 140 patients in each group. Given that prevalence of H. pylori among dyspeptic individuals in Pelotas is 75%, 13 recruiting 140 H. pylorinegative dyspeptic patients would require a total of approximately 560 patients.…”

Section: Methodsmentioning

confidence: 99%

“…The gold-standard for diagnosing H. pylori infection was the breath test with 13 C-labeled urea ( 13 C-UBT). Two teams of two interviewers each were trained to administer questionnaires and to carry out breath tests.…”

Section: Methodsmentioning

confidence: 99%

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Validade de instrumento epidemiológico para rastrear H. pylori entre pacientes dispépticos

et al. 2009

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OBJECTIVE:To validate an epidemiological score for identifying dyspeptic patients at high risk of being H. pylori positive. METHODS:Cross-sectional study including 434 users of primary health care units in the city of Pelotas, Southern Brazil, aged 18-45 years, and with symptoms of non-investigated dyspepsia, between 2006 and 2007. Dyspepsia was diagnosed according to Roma-II. The gold standard for H. pylori infection was the 13 C-urea-breath-test. The association between presence of H. pylori and independent variables was assessed through Logistic Regression. The score was built based on adjusted odds ratios. Sensitivity, specifi city, and predictive values of different cutoffs were calculated. RESULTS:Prevalence of H. pylori dyspeptic subjects was 73.5% (95% CI: 69.3; 77.7). Prevalence was directly associated with age and number of siblings during childhood, and inversely associated with schooling; these variables were used in the construction of the score. The score ranged from 3 to 9 points. Scores 7, 8, and 9 had sensitivity of 36.6%, 22.3%, and 11.1%, and positive predictive values of 87.8%, 90.9%, and 92.1%, respectively. Without the score, 3 in every 4 dyspeptic patients would have received H. pylori erradication therapy. This proportion would have been lower with the score (one in three, six, and 11, for the cutoff points betwewen 7 and 9, respectively), albeit at the expense of a high rate of false-negatives. CONCLUSIONS:The score was not valid for selectively identifying dyspeptic individuals candidate to eradication therapy for H. pylori. Contrary to the recommendation in developed countries, the test-and-treat strategy seems inappropriate for use in developing settings due to the high prevalence of H. pylori infection.

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Prevalence of Helicobacter pyloriinfection and associated factors among adults in Southern Brazil: a population-based cross-sectional study

Cited by 59 publications

References 29 publications

3rd BRAZILIAN CONSENSUS ON Helicobacter pylori

3rd BRAZILIAN CONSENSUS ON Helicobacter pylori

Seroprevalence of Helicobacter pylori infection in chagasic and nonchagasic patients from the same geographical region of Brazil

Validade de instrumento epidemiológico para rastrear H. pylori entre pacientes dispépticos

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