Prevalence of Helicobacter�pylori infection among dyspeptic patients in Northwestern Romania: A decreasing epidemiological trend in the last 30�years

Corojan, Alexandra Loor; Dumitraşcu, Dinu Iuliu; Ciobanca, Petrica T.; Leucuţa, Daniel-Corneliu

doi:10.3892/etm.2020.9024

Cited by 16 publications

(17 citation statements)

References 17 publications

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“…On analyzing the prevalence of H. pylori infection among various age groups, it was found that the prevalence was higher in subjects between 18 and 50 years of age (40.5% in 18-30 years and 43.6 % in 31-50 years). This is much higher than that reported by Corojan et al who reported it to be around 11% in 18-29 years and 20%-24% in those aged 30-59 years ago [28].…”

Section: Discussioncontrasting

confidence: 56%

Potential Predictors and Prevalence of Helicobacter pylori Infection Among Adult Patients With Dyspepsia: A Retrospective Study From Qatar

Naushad

Purayil

Badi

et al. 2021

Cureus

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To study the prevalence of Helicobacter pylori (H. pylori) infection among dyspeptic patients of various ethnic origins in Qatar and determine the association between H. pylori infection and various demographic factors and endoscopic findings. MethodsA retrospective data review was carried at Alkhor Hospital, Hamad Medical Corporation, Qatar. Adult patients who underwent endoscopy for the evaluation of dyspepsia between January 2011 to December 2017 were included. Patients who underwent endoscopy for reasons other than dyspepsia and those with incomplete data were excluded. ResultsOf the 638 subjects included, 58.9% were males, and the mean age of the subjects was 42.2 years (range 18-79 years). Epigastric pain (80.6%) was the most common symptom, followed by heartburn (26.2%). Forty point nine percent (40.9%) had a positive Campylobacter-like organism (CLO) test for H. pylori. A higher prevalence of H. pylori infection was observed among subjects between 31-50 years of age (43.6%) and 18-30 years (40.5%), and in Asian (42.2%) and Middle East and North African nationals (MENA) nationals (40%). Among the endoscopic findings, esophagitis (P=0.002) and gastritis (P=0.001) showed a statistically significant correlation with H. pylori positivity. Univariate regression analysis revealed an increased risk for H. pylori infection among all age groups except above 65 years, with an odds ratio (OR) of more than 2 in all the three age groups. Among various ethnicities, patients from Asia and MENA countries showed an increased risk of getting H. pylori infection (OR 1.16, 95% CI; 0.77,1.75 and OR 1.06, 95% CI 0.70,-1.61 respectively). The multivariable logistic regression analysis showed that subjects with endoscopic findings of esophagitis (adjusted OR 1.67, 95%CI 1.19, 2.34; P=0.003), gastritis (adjusted OR 1.79, 95%CI 1.27, 2.57; P=0.001), and duodenal ulcer (adjusted OR 2.41, 95%CI 1.24, 4.70; P=0.010) remained significantly associated with an increased risk of having H. pylori infection. ConclusionThe burden of H. pylori infection in patients with dyspepsia undergoing endoscopy is not low in Qatar. Less than 65 years of age, Asian nationals, and being from the MENA region were the demographic predictors for H. pylori infection. The finding of esophagitis, gastritis, and duodenal ulcer on endoscopy were independent endoscopic predictors for having H. pylori infection.

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Section: Discussioncontrasting

confidence: 56%

Potential Predictors and Prevalence of Helicobacter pylori Infection Among Adult Patients With Dyspepsia: A Retrospective Study From Qatar

Naushad

Purayil

Badi

et al. 2021

Cureus

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“…Another study investigating the symptoms in patients with H. pylori infection and bile reflux, reported nausea as the main complaint in patients with DGR, while in patients with H. pylori gastritis, epigastric pain was the most frequent symptom, followed by heartburn (20). Nevertheless, H. pylori infection was detected in only 40% of dyspeptic patients in the Romanian population, the role of other underlying conditions playing an important role (21).…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pylori infection over bile reflux: No influence on the severity of endoscopic or premalignant gastric lesion development

Szoke

Mocan²,

Negovan

2021

Exp Ther Med

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Helicobacter (H.) pylori infection and duodenogastric reflux (DGR) are both linked to endoscopic and premalignant gastric lesion development, but it is still unclear whether they are independent or have a causal relationship. This study investigated the histologic gastric changes in patients with primary DGR and H. pylori infection, as well as their endoscopic findings, symptoms, drug consumption, and social behavior in comparison with patients presenting only DGR. The study included 560 patients with primary DGR on endoscopy divided into two groups, according to the presence/absence of H. pylori infection on biopsy (utilizing usual stainings and immunohistochemical methods). There was no significant difference in terms of age and sex, nor in the frequency of diabetes or esophagitis between the studied groups. Epigastric pain was associated with H. pylori-positive biopsies in multivariate logistic regression analysis (P=0.005). Although without statistical significance, severe endoscopic lesions and premalignant gastric lesions were more frequent in the H. pylori group (45.1 vs. 28.4% and 37.4 vs. 32.3%, respectively). In patients with DGR, the final multivariate model revealed a positive association between smoking and immunohistochemically confirmed H. pylori infection (P=0.02, OR=1.88, 95% confidence intervals (CI)=1.10 to 3.21), but a negative effect of proton pump inhibitor consumption (P<0.001, OR=0.50, 95% CI=0.35 to 0.73). In conclusion, in patients with H. pylori infection and DGR, epigastric pain was the main reason for the endoscopic investigation. H. pylori infection over DGR did not influence the severity of endoscopic or premalignant gastric lesion development. Furthermore, smoking is directly related to immunohistochemically assessed active H. pylori infection in patients with bile reflux.

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“…There is a clear lack of large-scale epidemiological data on the prevalence of H. pylori in neighboring countries as well as in whole Eastern–Central European region. Epidemiological studies in recent years have shown the different prevalence of H. pylori in the neighboring countries [ 22 , 23 , 24 , 25 , 26 , 27 ]. It has been stated that the prevalence of H. pylori among Latvian adults ( n = 3564) was 79.2% in the year 2011 [ 22 ], and in fact there was no significant decrease of this infection among Latvian children during a 10-year period (2000–2010) [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…In Estonian children, the H. pylori seroprevalence rate was 42% in 1991 and 28.1% in 2002 [ 25 ]. Review articles [ 11 ] and other studies concluded that the prevalence of H. pylori ranges from 13% in children [ 28 ] to 65.6% in adults [ 26 ] in Russia, and is about 32% in Hungary [ 26 ], 23.5% in Czech Republic, 35.8% in Poland [ 10 ] and 40.8% in Romania [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Changes in the Seroprevalence of Helicobacter pylori among the Lithuanian Medical Students over the Last 25 Years and Its Relation to Dyspeptic Symptoms

et al. 2021

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Background and Objectives: The prevalence of Helicobacter pylori infection is decreasing in the Western world, while remaining high in developing countries. There is limited up-to-date information about the prevalence of H. pylori in Central and Eastern Europe. The aim of our study was to assess the seroprevalence of H. pylori and its trend over the past 25 years among students of the Lithuanian University of Health Sciences (LUHS) and to assess its relation to dyspeptic symptoms. Materials and Methods: In the years 1995, 2012, 2016 and 2020, students from Medical and Nursing Faculties of LUHS were tested for the presence of antibodies against H. pylori by performing serological tests from finger capillary blood. In addition, in the years 2012, 2016 and 2020, the students completed a gastrointestinal symptom rating scale (GSRS) questionnaire in order to assess dyspeptic symptoms. The study population consisted of 120 students in the year 1995 (mean age—21.3 ± 1.0 years), 187 students in the year 2012 (mean age—22.4 ± 0.7 years), 262 students in the year 2016 (mean age—20.4 ± 1.0 years) and 148 students in the year 2020 (mean age—20.4 ± 1.7 years). Results: The seroprevalence for H. pylori was positive in 62 (51.7%) students in 1995, in 57 (30.4%) students in 2012, in 69 (26.3%) students in 2016 and in 21 (14.2%) students in 2020. The statistically significant difference was found between all study years, except between 2012 and 2016. There were no significant differences in frequency and intensity of upper dyspeptic symptoms between H. pylori positive and negative students. Conclusions: Over the last 25 years the seroprevalence of H. pylori among students of LUHS has decreased significantly. No consistent differences in dyspeptic symptoms among H. pylori positive and negative subgroups were found.

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Prevalence of Helicobacter�pylori infection among dyspeptic patients in Northwestern Romania: A decreasing epidemiological trend in the last 30�years

Cited by 16 publications

References 17 publications

Potential Predictors and Prevalence of Helicobacter pylori Infection Among Adult Patients With Dyspepsia: A Retrospective Study From Qatar

Potential Predictors and Prevalence of Helicobacter pylori Infection Among Adult Patients With Dyspepsia: A Retrospective Study From Qatar

Helicobacter pylori infection over bile reflux: No influence on the severity of endoscopic or premalignant gastric lesion development

Changes in the Seroprevalence of Helicobacter pylori among the Lithuanian Medical Students over the Last 25 Years and Its Relation to Dyspeptic Symptoms

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