Prevalence of Helicobacter pylori infection in stress-induced gastric mucosal injury

Abstract

The severity of gastric and duodenal mucosal injury in critically ill patients during mechanical ventilation is significantly correlated with the presence of H. pylori infection.

An observational study of upper gastrointestinal bleeding in intensive care units: Is Helicobacter pylori the culprit?*

“…Gastric lesions commonly seen in ICU patients range from intramucosal lesions to ulcers. Gastric mucosal lesions are frequent in critically ill patients (24,25), although only a minority of such patients develop overt bleeding (5,6). In this study, the overall incidence of clinically relevant UGIB was Ͻ1%.…”

“…In ICU patients requiring mechanical ventilation, urea breath testing with a laser-assisted ratio analyzer demonstrated a higher prevalence of H. pylori infection in patients with major gastric mucosal injury, which was more extensive in patients with active H. pylori infection (25). However, despite its accuracy, this method is not readily available in all hospitals.…”

Management by the intensivist of gastrointestinal bleeding in adults and children

“…Three studies have reported a statistical link between Helicobacter pylori infection and stress-related GI bleeding [118-120]. Data from two of them differ according to the tests used to diagnose Helicobacter pylori infection [118,119]. By coupling several diagnostic methods (serology, biopsy, enzyme immunoassay detection of antigen in stools), Maury et al found a significantly greater incidence of Helicobacter pylori infection in the case of GI bleeding (36% vs. 16%) [120].…”

Laser based 14C counting, an alternative to AMS in biological studies

“…Previous success using LARA for breath testing [5][6][7][8][9][10][11][12][13] and environmental monitoring [14] led to the development of the novel technique for the detection of 14 C herein reported.…”