Laser based 14C counting, an alternative to AMS in biological studies

Murnick, D. E.; Dogru, Ozgur; Ilkmen, Erhan

doi:10.1016/j.nimb.2007.02.080

Cited by 12 publications

(9 citation statements)

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“…Cancio Pastor reported on the use of a frequency-comb referenced difference frequency generation laser in combination with cavity ring down spectroscopy to achieve a detection limit of ∼ 8 × 10 −11 in a 1 s bandwidth [70]. Murnick, using intra-cavity optogalvanic detection, reported a projected detection limit of better than 10 −12 on microgram CO 2 samples and a few minutes averaging, making the method a viable alternative to accelerator mass spectrometry, for example for biomedical 14 C-tracer experiments [71,72].…”

Section: Using Optical Cavities To Increase the Effective Absorption mentioning

confidence: 99%

Advances in laser-based isotope ratio measurements: selected applications

2008

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Advances in laser-based isotope ratio measurementsKerstel, E.; Gianfrani, L. Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. ABSTRACT Small molecules exhibit characteristic ro-vibrational transitions in the near-and mid-infrared spectral regions, which are strongly influenced by isotopic substitution. This gift of nature has made it possible to use laser spectroscopy for the accurate analysis of the isotopic composition of gaseous samples. Nowadays, laser spectroscopy is clearly recognized as a valid alternative to isotope ratio mass spectrometry. Laserbased instruments are leaving the research laboratory stage and are being used by a growing number of isotope researchers for significant advances in their own field of research. In this review article, we discuss the current status and new frontiers of research on high-sensitivity and high-precision laser spectroscopy for isotope ratio analyses. Although many of our comments will be generally applicable to laser isotope ratio analyses in molecules of environmental importance, this paper concerns itself primarily with water and carbon dioxide, two molecules that were studied extensively in our respective laboratories. A complete coverage of the field is practically not feasible in the space constraints of this issue, and in any case doomed to fail, considering the large body of work that has appeared ever since the review by Kerstel in 2004 (Handbook of Stable Isotope Analytical Techniques, Chapt. 34, pp.

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Section: Using Optical Cavities To Increase the Effective Absorption mentioning

confidence: 99%

Advances in laser-based isotope ratio measurements: selected applications

2008

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“…Sensitivity is achieved via the laser optogalvanic effect (OGE). As discussed at the previous AMS Conference[4], LARA’s sensitivity and versatility make new classes of isotope ratio measurement systems possible[5]. …”

Section: Introductionmentioning

confidence: 99%

14C analysis via intracavity optogalvanic spectroscopy

Murnick

Dogru

Ilkmen

2010

Nuclear Instruments and Methods in Physics Research Section B:

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A new ultra sensitive laser-based analytical technique, intracavity optogalvanic spectroscopy (ICOGS), allowing extremely high sensitivity for detection of 14 C-labeled carbon dioxide has recently been demonstrated. Capable of replacing accelerator mass spectrometers (AMS) for many applications, the technique quantifies zeptomoles of 14 C in sub micromole CO 2 samples. Based on the specificity of narrow laser resonances coupled with the sensitivity provided by standing waves in an optical cavity, and detection via impedance variations, limits of detection near 10 −15 14 C/ 12 C ratios have been obtained with theoretical limits much lower. Using a 15 W 14 CO 2 laser, a linear calibration with samples from 5 × 10 −15 to >1.5 × 10 −12 in 14 C/ 12 C ratios, as determined by AMS, was demonstrated. Calibration becomes non linear over larger concentration ranges due to interactions between CO 2 and buffer gas, laser saturation effects and changes in equilibration time constants. The instrument is small (table top), low maintenance and can be coupled to GC or LC input. The method can also be applied to detection of other trace entities. Possible applications include microdosing studies in drug development, individualized sub therapeutic tests of drug metabolism, carbon dating and real time monitoring of atmospheric radiocarbon.

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“…Extension of the LARA technique to 14 CO 2 was previously established with highly enriched (nanocurie) 14 C samples . In those studies, an isotope ratio ( 14 C/ 12 C) sensitivity of order 10 −9 was demonstrated with a very simple external cavity configuration.…”

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Intracavity Optogalvanic Spectroscopy. An Analytical Technique for ¹⁴C Analysis with Subattomole Sensitivity

2008

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We show a new ultrasensitive laser-based analytical technique, intracavity optogalvanic spectroscopy, allowing extremely high sensitivity for detection of (14)C-labeled carbon dioxide. Capable of replacing large accelerator mass spectrometers, the technique quantifies attomoles of (14)C in submicrogram samples. Based on the specificity of narrow laser resonances coupled with the sensitivity provided by standing waves in an optical cavity and detection via impedance variations, limits of detection near 10(-15) (14)C/(12)C ratios are obtained. Using a 15-W (14)CO2 laser, a linear calibration with samples from 10(-15) to >1.5 x 10(-12) in (14)C/(12)C ratios, as determined by accelerator mass spectrometry, is demonstrated. Possible applications include microdosing studies in drug development, individualized subtherapeutic tests of drug metabolism, carbon dating and real time monitoring of atmospheric radiocarbon. The method can also be applied to detection of other trace entities.

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Laser based 14C counting, an alternative to AMS in biological studies

Cited by 12 publications

References 14 publications

Advances in laser-based isotope ratio measurements: selected applications

Advances in laser-based isotope ratio measurements: selected applications

14C analysis via intracavity optogalvanic spectroscopy

Intracavity Optogalvanic Spectroscopy. An Analytical Technique for ¹⁴C Analysis with Subattomole Sensitivity

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Laser based 14C counting, an alternative to AMS in biological studies

Cited by 12 publications

References 14 publications

Advances in laser-based isotope ratio measurements: selected applications

Advances in laser-based isotope ratio measurements: selected applications

14C analysis via intracavity optogalvanic spectroscopy

Intracavity Optogalvanic Spectroscopy. An Analytical Technique for 14C Analysis with Subattomole Sensitivity

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Intracavity Optogalvanic Spectroscopy. An Analytical Technique for ¹⁴C Analysis with Subattomole Sensitivity