Prevalence of Helicobacter pylori infection in coronary artery disease and effect of its eradication an coronary lumen reduction after percutations coronaryangioplasty

Role of Infectious and Immune Factors in Coronary and Cerebrovascular Arteriosclerosis

“…A population-based study did not find an association of elevated H. pylori antibodies with ischemic stroke; however, H. pylori infection was associated with strokes caused by smallartery occlusion (39). To explain the contradictory results regarding the association of H. pylori with arteriosclerosis, it was suggested that strains expressing the virulent cytotoxin-associated gene product A (CagA) are more strongly related to coronary heart disease than are other strains of H. pylori (51). A study in late-middle-aged men, however, showed that CagApositive strains appear to be no more strongly related to the disease than other strains (101).…”

“…Long-term azithromycin treatment did not affect levels of the adhesion molecules in plasma over a period of 6 months (90). In a small study of patients after percutaneous coronary angioplasty with confirmed H. pylori infection, eradication therapy with clarithromycin, amoxycillin, and omeprazole for 1 week significantly attenuated reduction of the coronary artery lumen (51). Up to now, three treatment trials with antibiotics for secondary prevention of coronary artery disease events in humans have been carried out (see Table 1) (33,34,72).…”

Helicobacter Pylori Seropositivity in Patients with Postmenopausal Osteoporosis

“…Since gastric acid is thought to be necessary for the absorption of dietary calcium, osteoporosis in gastrointestinal diseases has been attributed to calcium deficiency [9][10][11][12] . Helicobacter pylori (HP) infection also causes chronic gastritis and may cause i n f l a m m a t i o n b y i n c r e a s i n g l o c a l a n d s y s t e m i c inflammatory markers such as TNF-alpha and IL-6 [13][14][15] . TNF-alpha and IL-6 were previously proposed as being part of the etiology of osteoporosis and the prevalence of HP infection increases with age 2,16) .…”

Review. The Link between Periodontal Disease, Inflammation and Atherosclerosis — an Interdisciplinary Approach

“…[42][43][44] It has also been proved that the presence of P. gingivalis in atherosclerotic plaques accelerates the progression of abdominal aortic aneurysms, 42,43 and Kowalski et al demonstrated that infection with oral pathogens is associated with a significantly greater lumen loss at 6 months after stent implantation, proving that periodontal disease and associated bacteria can also be involved in the complex mechanism of in-stent restenosis. 45 Armingohar et al extracted DNA from vascular biopsies obtained from patients with peripheral vascular disease and found a significantly higher bacterial load in patients with vascular disease associating periodontal disease as compared to those without periodontal disease. 46,47 …”