Prevalence of Helicobacter pylori in benign gastric ulcers in a cohort of Sri Lankan patients

Wijetunge, Sulochana; Kotakadeniya, R; Noordeen, F.; Buharideen, S M; Samarasinghe, Bandula; Dharmapala, A. D.; Galketiya, K. B.

doi:10.4038/cmj.v60i4.8224

Cited by 4 publications

(2 citation statements)

References 10 publications

(16 reference statements)

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“…H. pylori gastric colonization is acquired early in life (almost always before the age of 10 years), and, in the absence of antibiotic therapy, generally persists for life[12,22,23]. The prevalence of H. pylori ranges from 35% to 90% in different populations[21,24-28]. It presents in 70%-90% of the population in developing countries and 35%-40% in developed ones[21,29].…”

Section: H Pylori Is One Of the Etiological Factors Of Pudmentioning

confidence: 99%

Significance of dormant forms ofHelicobacter pyloriin ulcerogenesis

Reshetnyak

2017

WJG

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Nearly half of the global population are carriers of Helicobacter pylori (H. pylori), a Gram-negative bacterium that persists in the healthy human stomach. H. pylori can be a pathogen and causes development of peptic ulcer disease in a certain state of the macroorganism. It is well established that H. pylori infection is the main cause of chronic gastritis and peptic ulcer disease (PUD). Decontamination of the gastric mucosa with various antibiotics leads to H. pylori elimination and longer remission in this disease. However, the reasons for repeated detection of H. pylori in recurrent PUD after its successful eradication remain unclear. The reason for the redetection of H. pylori in recurrent PUD can be either reinfection or ineffective anti-Helicobacter therapy. The administration of antibacterial drugs can lead not only to the emergence of resistant strains of microorganisms, but also contribute to the conversion of H. pylori into the resting (dormant) state. The dormant forms of H. pylori have been shown to play a potential role in the development of relapses of PUD. The paper discusses morphological H. pylori forms, such as S-shaped, C-shaped, U-shaped, and coccoid ones. The authors proposes the classification of H. pylori according to its morphological forms and viability.

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Section: H Pylori Is One Of the Etiological Factors Of Pudmentioning

confidence: 99%

Significance of dormant forms ofHelicobacter pyloriin ulcerogenesis

Reshetnyak

2017

WJG

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“…The role of TNF‐α polymorphisms in severity of H. pylori‐ associated disease has not been studied in Sri Lanka. Previous histological studies done in Sri Lanka have suggested that most H. pylori‐ infected patients have mild chronic gastritis and that development of gastric atrophy is not a significant problem. Multiple factors can contribute to a shift from mild to atrophic gastritis; however, host genetic factors can play a major role.…”

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confidence: 98%

Association of tumor necrosis factor alpha gene polymorphisms with Helicobacter pylori infection in dyspeptic patients in Sri Lanka

Arachchi

Weerasekera

Senevirathna

et al. 2018

Microbiology and Immunology

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Single nucleotide polymorphisms present on the promoter sequence of the TNF-α gene may affect production of TNF-α, a pro-inflammatory cytokine, during immune responses. The presence of TNF-α polymorphisms is also reportedly associated with more severe manifestations of Helicobacter pylori infection. However, the frequency of TNF-α polymorphisms and the associated disease severity vary between different patient groups. In this study, gastric biopsies and blood specimens were collected from 138 patients with dyspepsia undergoing routine upper gastrointestinal endoscopy. Our institution's Ethics Review Committee approved the study and written informed consent was obtained from all participants. The presence of H. pylori was confirmed histologically in all patients. The frequency of TNF-α polymorphisms in the study cohort was investigated using PCR-restriction fragment length polymorphism and expression of serum TNF-α quantitated using a commercial ELISA assay. The proportions of selected TNF-α polymorphisms (TNF-α -238, -308 and -863) were similar in H. pylori-positive and -negative patients. Homozygous mutations of TNF-α polymorphisms were rarely detected in the study group. There was a significant difference in TNF-α concentrations between patients with mild chronic gastritis and TNF-α -308 GG genotype and patients with moderate to severe chronic gastritis (P = 0.008). It was not possible to identify an association between these genotypes and disease severity because of the low frequency of heterozygous and homozygous mutated genes in Sri Lankan patients with dyspepsia.

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The Contribution of Drugs and Helicobacter pylori to Gastric Mucosa Changes in Patients with Systemic Lupus Erythematosus and Antiphospholipid Syndrome

Reshetnyak

Дорошкевич

Середавкина

et al. 2019

International Journal of Rheumatology

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Background. The nature and rate of gastric mucosal (GM) damage in systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) remain to be among the unsolved problems. Objective. To define the role of H. pylori and drugs in the development of GM damages in SLE and APS. Methods. A study was conducted on 85 patients with SLE and APS. All the patients underwent esophagogastroduodenoscopy with targeted biopsy of the mucosa of the gastric body and antrum. The presence of H. pylori in the gastric biopsy specimens was determined using polymerase chain reaction. Results. Endoscopic examination revealed that the patients with SLE and APS on admission had the following GM changes: antral gastritis (82.4%), erosions (24.7%), hemorrhages (8.2%), and pangastritis (8.2%). SLE and APS patients showed no direct correlation between the found GM damages and the presence of H. pylori. The use of glucocorticoid, low-dose acetylsalicylic acid, nonsteroidal anti-inflammatory drug, and anticoagulant in SLE and APS patients is accompanied by GM damage. Conclusion. There was no evidence of the role of H. pylori in GM damage in the SLE and APS patients. More frequent detection of H. pylori was observed in anticoagulants or low-dose acetylsalicylic acid users than in glucocorticoids and nonsteroidal anti-inflammatory drugs ones.

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Prevalence of Helicobacter pylori in benign gastric ulcers in a cohort of Sri Lankan patients

Cited by 4 publications

References 10 publications

Significance of dormant forms ofHelicobacter pyloriin ulcerogenesis

Significance of dormant forms ofHelicobacter pyloriin ulcerogenesis

Association of tumor necrosis factor alpha gene polymorphisms with Helicobacter pylori infection in dyspeptic patients in Sri Lanka

The Contribution of Drugs and Helicobacter pylori to Gastric Mucosa Changes in Patients with Systemic Lupus Erythematosus and Antiphospholipid Syndrome

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