Prevalence of Helicobacter pylori in dyspeptic patients at a tertiary hospital in a low resource setting

Abstract

BackgroundMore than half of the world’s population is infected with Helicobacter pylori (H. pylori), the primary cause of chronic gastritis. Chronic gastritis is associated with peptic ulcer and in advanced stages with an increased risk of developing gastric adenocarcinoma. In many developing countries access to upper gastrointestinal (UGI) endoscopy services is limited. As a result, many UGI diseases are treated empirically.ObjectiveTo determine the prevalence of H. pylori in patients presenting with dyspepsia, and the mean time from onset of symptoms to performing an endoscopy examination.MethodsA cross sectional descriptive study conducted from 5th January to 30th April 2014. Adult patients with dyspepsia who were referred for UGI endoscopy were recruited consecutively. Questionnaires were used to collect data which were analyzed using STATA software. IRB approval was obtained.ResultsIn total, 111 participants’ data were analyzed. The F:M ratio was 1:1.4, mean age 43 years (SD = 16). The prevalence of H. pylori gastritis was 36%. The minimum time to endoscopy was 3 weeks, maximum 1,248 weeks and the mean time 57 weeks.ConclusionThe burden of H. pylori infection in patients with dyspepsia was high. Patients had prior empirical antibiotic therapy. Access to endoscopic services is limited.

The effect of statins on the occurrence of peptic ulcer

“…Because of this, many patients with PUD are treated empirically Table 3 Hazard ratios and 95% confidence intervals of peptic ulcer diseases associated with cumulative defined daily dose of statins. [33]. In the last decade though, the causes of PUD have changed from H. pylori to NSAIDs or idiopathic ulcers.…”

Helicobacter Pylori Infection in Brazzaville: Comparative Study of Two Identification Tests

“…This is the case of Shmuely et al in Nakuru (Kenya), which obtained a frequency of 71% in 2013 [13]. Werme et al Obtained only 36% in Kampala (Uganda) the same year but related the weakness of this frequency to longer duration of their study [15].…”

Bacteriological Investigation of Helicobacter pylori Infections in Patients with Gastric and Duodenal Ulcer

“…While Obayo et al, (2015) H. pylori was diagnosed in 75.6% among the biopsied patients. Oling et al, 2015 found the prevalence of H. pylori gastritis was 36%. In China the mean prevalence of H. pylori infection in the endoscopy-referral patient population was 31.97 %, and it mirrored a marked significant linear decline trend from 42.40 % in 2003to 23.82 % in 2012as reported by Jianget al, 2016.Ansari et al, 2016 found the overall prevalence of colonization of H. pylori was found as less as to be 16%.…”

“…The incidence of H. pylori infection in Ghana may be lower than previously reported due to changing socioeconomic factors, increased PPI and antibiotic useAdu-Aryeeet al, 2016). The burden of H. pylori infection among dyspeptic patients was high which decrease after antibiotic empirical treatment (Oling et al, 2015).…”

“…HpSAg is used for noninvasive and costs a fraction of what is usually charged for endoscopy. Oling et al, (2015) diagnosis of H. pylori infection in biopsy specimen using the Modified Giemsa stain which is easy to interpret, inexpensive, and takes about 5 min to perform, and rarely requires repeat stains. It has a sensitivity of 98% and specificity of 90%.…”